Shaped hemocompatible aerogels from cellulose phosphates: preparation and properties

Liebner, Falk; Dunareanu, Ramona; Opietnik, Martina; Haimer, Emmerich; Wendland, Martin; Werner, Carsten; Maitz, Manfred F.; Seib, F. Philipp; Néouze, Marie-Alexandra; Potthast, Antje; Rosenau, Thomas

doi:10.1515/hf.2011.163

Cited by 18 publications

(18 citation statements)

References 18 publications

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“…The most eye-catching feature however is the pronounced plateau region (15–40%), caused by plastic deformation through cell collapsing and eventually followed by an exponential increase of stress over strain due to material densification. Similar to aerogels from regenerated cellulose (Liebner, Dunareanu et al, 2012) – and in contrast to brittle foams and silica aerogels – all composite aerogels deformed in a ductile way on the microscale.…”

Section: Resultsmentioning

confidence: 99%

Reinforcement of bacterial cellulose aerogels with biocompatible polymers

Pircher

Veigel

Aigner

et al. 2014

Carbohydrate Polymers

106

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Section: Resultsmentioning

confidence: 99%

Reinforcement of bacterial cellulose aerogels with biocompatible polymers

Pircher

Veigel

Aigner

et al. 2014

Carbohydrate Polymers

106

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“…Aerogels are solids that feature very low density, high specific surface area and consist of a coherent open-porous network of loosely-packed, bonded particles or fibers [1], which distinguishes them from other porous materials, like liquid foams, packed beds or open-porous metal foams. Their particular morphology in terms of high interconnected porosity (≤99.9 vol%) and large internal surface (≤1000 m²·g −1 ) render aerogels promising matrix materials for a variety of applications.…”

Section: Introductionmentioning

confidence: 99%

Preparation, Characterization and Activity of a Peptide-Cellulosic Aerogel Protease Sensor from Cotton

Edwards

Fontenot

Prevost

et al. 2016

Sensors

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Nanocellulosic aerogels (NA) provide a lightweight biocompatible material with structural properties, like interconnected high porosity and specific surface area, suitable for biosensor design. We report here the preparation, characterization and activity of peptide-nanocellulose aerogels (PepNA) made from unprocessed cotton and designed with protease detection activity. Low-density cellulosic aerogels were prepared from greige cotton by employing calcium thiocyanate octahydrate/lithium chloride as a direct cellulose dissolving medium. Subsequent casting, coagulation, solvent exchange and supercritical carbon dioxide drying afforded homogeneous cellulose II aerogels of fibrous morphology. The cotton-based aerogel had a porosity of 99% largely dominated by mesopores (2–50 nm) and an internal surface of 163 m2·g−1. A fluorescent tripeptide-substrate (succinyl-alanine-proline-alanine-4-amino-7-methyl-coumarin) was tethered to NA by (1) esterification of cellulose C6 surface hydroxyl groups with glycidyl-fluorenylmethyloxycarbonyl (FMOC), (2) deprotection and (3) coupling of the immobilized glycine with the tripeptide. Characterization of the NA and PepNA included techniques, such as elemental analysis, mass spectral analysis, attenuated total reflectance infrared imaging, nitrogen adsorption, scanning electron microscopy and bioactivity studies. The degree of substitution of the peptide analog attached to the anhydroglucose units of PepNA was 0.015. The findings from mass spectral analysis and attenuated total reflectance infrared imaging indicated that the peptide substrate was immobilized on to the surface of the NA. Nitrogen adsorption revealed a high specific surface area and a highly porous system, which supports the open porous structure observed from scanning electron microscopy images. Bioactivity studies of PepNA revealed a detection sensitivity of 0.13 units/milliliter for human neutrophil elastase, a diagnostic biomarker for inflammatory diseases. The physical properties of the aerogel are suitable for interfacing with an intelligent protease sequestrant wound dressing.

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“…The results were also a motivation to re-check similar hwPHK-P retention samples of a previous study for any possible reduction of DS P . These samples had been used for preparation of potential cell scaffolding materials via the Lyocell route [39]. Cellulose was here dissolved in molten N-methylmorpholine-N-oxide monohydrate (NMMO·H 2 O) at 100 • C using propyl gallate and N-benzylmorpholine-N-oxide (NBnMO) as stabilizers.…”

Section: Chemical Integrity Of Cellulose Phosphates During Dissolutionmentioning

confidence: 99%

“…Already at low degrees of phosphorylation (DS P ca. 0.2), biomineralization and good hemocompatibility in terms of hemostasis and inflammatory response were observed [39]. However, some shortcomings of NMMO related to its elevated melting point, its proneness towards autocatalytic degradation (in the presence of acidic phosphate groups) and the specific solidification behavior of cooling dopes were reasons enough to look for alternatives.…”

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confidence: 99%

Aerogels from Cellulose Phosphates of Low Degree of Substitution: A TBAF·H2O/DMSO Based Approach

et al. 2020

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Biopolymer aerogels of appropriate open-porous morphology, nanotopology, surface chemistry, and mechanical properties can be promising cell scaffolding materials. Here, we report a facile approach towards the preparation of cellulose phosphate aerogels from two types of cellulosic source materials. Since high degrees of phosphorylation would afford water-soluble products inappropriate for cell scaffolding, products of low DS P (ca. 0.2) were prepared by a heterogeneous approach. Aiming at both i) full preservation of chemical integrity of cellulose during dissolution and ii) utilization of specific phase separation mechanisms upon coagulation of cellulose, TBAF·H 2 O/DMSO was employed as a non-derivatizing solvent. Sequential dissolution of cellulose phosphates, casting, coagulation, solvent exchange, and scCO 2 drying afforded lightweight, nano-porous aerogels. Compared to their non-derivatized counterparts, cellulose phosphate aerogels are less sensitive towards shrinking during solvent exchange. This is presumably due to electrostatic repulsion and translates into faster scCO 2 drying. The low DS P values have no negative impact on pore size distribution, specific surface (S BET ≤ 310 m 2 g −1 ), porosity (Π 95.5-97 vol.%), or stiffness (Eρ ≤ 211 MPa cm 3 g −1 ). Considering the sterilization capabilities of scCO 2 , existing templating opportunities to afford dual-porous scaffolds and the good hemocompatibility of phosphorylated cellulose, TBAF·H 2 O/DMSO can be regarded a promising solvent system for the manufacture of cell scaffolding materials.

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Shaped hemocompatible aerogels from cellulose phosphates: preparation and properties

Cited by 18 publications

References 18 publications

Reinforcement of bacterial cellulose aerogels with biocompatible polymers

Reinforcement of bacterial cellulose aerogels with biocompatible polymers

Preparation, Characterization and Activity of a Peptide-Cellulosic Aerogel Protease Sensor from Cotton

Aerogels from Cellulose Phosphates of Low Degree of Substitution: A TBAF·H2O/DMSO Based Approach

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