Shape switching of CaCO3-templated nanorods into stiffness-adjustable nanocapsules to promote efficient drug delivery

Liu, Yuan; Li, Yingxin; Xue, Guilan; Cao, Wenxiong; Zhang, Zhanlin; Wang, Chaomin; Li, Xiaohong

doi:10.1016/j.actbio.2021.04.011

Cited by 20 publications

(16 citation statements)

References 44 publications

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“…Cell internalization of NPs was evaluated after treatment with mSZ/US, mSZ@PDA/US, mSZ+NO/US, mSZ@PDA-NO/US, mSZ#PDA-NO/US, mSZ@PDA-NO/NIR, and mSZ@PDA-NO NPs without activation. 63 Briefly, H22, RAW 264.7, and NIH 3T3 cells were received from American Type Culture Collection (Rockville, MD, USA) and cultured in DMEM media supplemented with 10% fetal bovine serum (Gibco BRL, Grand Island, NY, USA). Cells were inoculated in 24-well tissue culture plates (TCPs) at 10 4 cells per well and treated with NPs at an equal concentration of mSZ (50 μg/mL) in hyaluronan solutions (3 mg/mL), followed by ultrasonication or NIR illumination for 5 min as above.…”

Section: Methodsmentioning

confidence: 99%

“…All the tissues were homogenized and lysed for 4 h with Triton X-100 (0.5%) to extract NPs, and the NP contents were detected by fluorescence spectrophotometry. 63 The NP level in a tissue was normalized to the injected dose and tissue weight (%ID/g). In addition, the harvested tumor tissues were frozenly sectioned and observed by CLSM after staining with DAPI.…”

Section: Methodsmentioning

confidence: 99%

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Ultrasound-Chargeable Persistent Luminescence Nanoparticles to Generate Self-Propelled Motion and Photothermal/NO Therapy for Synergistic Tumor Treatment

Zhang,

Yan,

Cao

et al. 2023

ACS Nano

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Cancer phototherapy indicates advantages in ease of manipulation, negligible drug resistance, and spatiotemporal control but is confronted with challenges in tumor cell accessibility and intermittent light excitation. Herein, we propose a strategy with persistent luminescence (PL)-excited photothermal therapy (PTT), concurrent thermophoresispropelled motion, and PL-triggered NO release, where PL emission is chargeable by ultrasonication for readily applicable to deep tumors. Mechanoluminescent (ML) nanodots of SrAl 2 O 4 :Eu 2+ (SAOE) and PL nanodots of ZnGa 2 O 4 :Cr 3+ (ZGC) were deposited on mesoporous silicates to obtain mSZ nanoparticles (NPs), followed by partially coating with polydopamine (PDA) caps and loading NO donors to prepare Janus mSZ@PDA-NO NPs. The ML emission bands of SAOE nanodots overlap with the excitation band of ZGC, and the persistent near-infrared (NIR) emission could be repeatedly activated by ultrasonication. The PL emission acts as an internal NIR source to produce a thermophoretic force and NO gas propellers to drive the motion of Janus NPs. Compared with the commonly used intermittent NIR illumination at both 660 and 808 nm, the persistent motion of ultrasound-activated NPs enhances cellular uptake and long-lasting PTT and intracellular NO levels to combat tumor cells without the use of any chemotherapeutic drugs. The ultrasound-activated persistent motion promotes intratumoral accumulation and tumor distribution of PTT/NO therapeutics and exhibits significantly higher tumor growth inhibition, longer animal survival, and larger intratumoral NO levels than those who experience external NIR illumination. Thus, this study demonstrates a strategy to activate PL emissions and construct PLexcited nanomotors for phototherapy in deep tissues.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Ultrasound-Chargeable Persistent Luminescence Nanoparticles to Generate Self-Propelled Motion and Photothermal/NO Therapy for Synergistic Tumor Treatment

Zhang,

Yan,

Cao

et al. 2023

ACS Nano

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“…For CaCO 3 nanorods, colloidal mesogens were used as pH-responsive components in the drug carrier for shape switching. 61 Liu et al used rod-shaped morphologies to prolong the blood circulation time and enhance extravasation into tumor tissues. The carriers obtained sphere-like morphologies by the removal of the CaCO 3 nanorods in response to an acidic tumor, leading to the promotion of tumor cell uptake, followed by the intracellular release of chemotherapeutic agents.…”

Section: Functionalization Of the Isotropic Phase Of The Hap Liquid C...mentioning

confidence: 99%

“…The nanorod mesogens in the isotropic phases have biocompatibility, colloidal stability, and drug loading and pH-responsive release ability, which can be useful for drug delivery to tumor sites and cancer therapy. We used a single colloidal mesogen component in the isotropic phase of the HAp liquid crystal as a drug nanocarrier for photodynamic therapy (PDT), while Liu and Fan used randomly dispersed colloidal CaCO 3 nanorods prepared by our methods for tumor therapy, PDT, and ultrasound bioimaging. , In our approach, MB was selected as a molecular model drug that generates singlet oxygen ( 1 O 2 ) under light excitation and kills cancer cells through oxidative stresses. HAp nanorods with MB molecules incorporated in the PAA shell region through electrostatic interactions showed absorbance peaks at 570 nm, which reflected a blue-shift from the absorbance at 665 nm for free MB (Figure a).…”

Section: Functionalization Of the Isotropic Phase Of The Hap Liquid C...mentioning

confidence: 99%

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Biomineral-Inspired Colloidal Liquid Crystals: From Assembly of Hybrids Comprising Inorganic Nanocrystals and Organic Polymer Components to Their Functionalization

Nakayama

Kato

2022

Acc. Chem. Res.

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Conspectus Bioinspired organic/inorganic synthetic composites have been studied as high-performance and functional materials. In nature, biominerals such as pearls, teeth, and bones are self-organized organic/inorganic composites. The inorganic components are composed of calcium carbonate (CaCO 3 ) and hydroxyapatite (HAp), while the organic components consist of peptides and polysaccharides. These composites are used as structural materials in hard biological tissues. Biominerals do not show significantly higher performances than synthetic composites such as glass-fiber- or carbon-fiber-reinforced plastics. However, biominerals consist of environmentally friendly and biocompatible components that are prepared under mild conditions. Moreover, they form elaborate nanostructures and self-organized hierarchical structures. Much can be learned about material design from these biomineral-based hierarchical and nanostructured composites to assist in the preparation of functional materials. Inspired by these biological hard tissues, we developed nanostructured thin films and bulk hybrid crystals through the self-organization of organic polymers and inorganic crystals of CaCO 3 or HAp. In biomineralization, the combination of insoluble components and soluble acidic macromolecules controls the crystallization process. We have shown that poly(acrylic acid) (PAA) or acidic peptides called polymer additives induce the formation of thin film crystals of CaCO 3 or HAp by cooperation with insoluble organic templates such as chitin and synthetic polymers bearing the OH group. Moreover, we recently developed CaCO 3 - and HAp-based nanostructured particles with rod and disk shapes. These were obtained in aqueous media using a macromolecular acidic additive, PAA, without using insoluble polymer templates. At appropriate concentrations, the anisotropic particles self-assembled and formed colloidal liquid-crystalline (LC) phases. LC materials are generally composed of organic molecules. They show ordered and mobile states. The addition of stimuli-responsive properties to organic rod-like LC molecules led to the successful development of informational displays, which are now widely used. On the other hand, colloidal liquid crystals are colloidal self-assembled dispersions of anisotropic organic and inorganic nano- and micro-objects. For example, polysaccharide whiskers, clay nanosheets, gibbsite plate-shaped particles, and silica rod-shaped particles exhibit colloidal LC states. In this Account, we focused on the material design and hierarchical aspects of biomineral-based colloidal LC polymer/inorganic composites. We describe the design and preparation, nanostructures, and self-assembled behavior of these new bioinspired and biocompatible self-organized materials. The characterization results for these self-assembled nanostructured colloidal liquid crystals found using high-resolution transm...

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Photothermal Propelling and Pyroelectric Potential‐Promoted Cell Internalization of Janus Nanoparticles and Pyroelectrodynamic Tumor Therapy

Wei

Liu

et al. 2023

Adv Healthcare Materials

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Cancer phototherapy experiences limitations in tissue diffusion and cell internalization of phototherapeutic agents and dose‐dependent side effects. Herein, Janus pyroelectric nanoparticles (NPs) are designed to generate self‐powered motion and built‐in electric fields to overcome the delivery barriers. Polydopamine (PDA) layers are partially coated on tetragonal BaTiO3 (tBT) NPs to prepare Janus tBT@PDA, and Au NPs are deposited on the PDA caps to obtain Janus tBT@PDA‐Au NPs. Near‐infrared (NIR) illumination of tBT@PDA‐Au builds in situ pyroelectric potentials on NPs, which selectively affect the membrane potential of tumor cells rather than normal cells to enhance tumor cell internalization and produce reactive oxygen species (ROS) for pyroelectric dynamic therapy (PEDT). The asymmetric photothermal effect of the Janus NPs creates thermophoretic force to propel NP motion, which enhances tumor diffusion and cellular uptake of NPs and boosts cytotoxicity and intracellular ROS levels. The inoculation of Au NPs increases the photothermal effect, exhibits larger motion velocities, produces higher pyroelectric potentials, and elevates cellular uptake rates, resulting in significant induction of tumor cell apoptosis, suppression of tumor growth, and extension of animal survival. Thus, the concise design of tBT@PDA‐Au/NIR treatment has achieved thermophoretic motion‐promoted tissue diffusion, built‐in electric field‐enhanced cell internalization, and photothermal/PEDT‐synergized antitumor efficacy.

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Shape switching of CaCO3-templated nanorods into stiffness-adjustable nanocapsules to promote efficient drug delivery

Cited by 20 publications

References 44 publications

Ultrasound-Chargeable Persistent Luminescence Nanoparticles to Generate Self-Propelled Motion and Photothermal/NO Therapy for Synergistic Tumor Treatment

Ultrasound-Chargeable Persistent Luminescence Nanoparticles to Generate Self-Propelled Motion and Photothermal/NO Therapy for Synergistic Tumor Treatment

Biomineral-Inspired Colloidal Liquid Crystals: From Assembly of Hybrids Comprising Inorganic Nanocrystals and Organic Polymer Components to Their Functionalization

Photothermal Propelling and Pyroelectric Potential‐Promoted Cell Internalization of Janus Nanoparticles and Pyroelectrodynamic Tumor Therapy

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