Shape optimization and characterization of polysaccharide beads prepared by ionotropic gelation

Smrdel, Polona; Bogataj, Marija; Zega, Anamarija; Planinšek, Odon; Mrhar, Aleš

doi:10.1080/02652040701776109

Cited by 50 publications

(37 citation statements)

References 27 publications

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“…Alginates undergo ionotropic gelation in aqueous solution in presence of divalent cations (e.g., Ca 2+ ), and trivalent cations (e.g., Al 3+ ) due to ionic cross-linking interaction with intermolecular bonding between the carboxylic acid groups located on the polymer back-bone and these cations [6]. Various drugs have been successfully incorporated in ionotropically cross-linked alginate hydrogels [7], and showed different patterns of drug encapsulation as well as release profiles depending on their physicochemical properties and method of preparations. However, the drug release properties of ionotropically cross-linked alginate hydrogels suffer from some serious problems.…”

Section: Introductionmentioning

confidence: 99%

Development of pH-sensitive tamarind seed polysaccharide–alginate composite beads for controlled diclofenac sodium delivery using response surface methodology

Nayak¹,

Pal

2011

International Journal of Biological Macromolecules

223

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Section: Introductionmentioning

confidence: 99%

Development of pH-sensitive tamarind seed polysaccharide–alginate composite beads for controlled diclofenac sodium delivery using response surface methodology

Nayak¹,

Pal

2011

International Journal of Biological Macromolecules

223

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“…In this technique, the microorganisms are added to an alginate solution and are immediately incorporated in the form of droplets in a solution of calcium chloride to hardening (YEO et al, 2001). The interaction of the ions, such as Ca 2+ , with the carboxyl groups of the polymer chains of the alginate results in the formation of an insoluble gel (SMRDEL et al, 2008).…”

Section: External Ionic Gelationmentioning

confidence: 99%

Microencapsulation of probiotics using sodium alginate

et al. 2015

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“…permit the formation of alginate matrices for gels, beads, and pellets [11]. This statement is supported by several papers reporting that drug release and/or encapsulation efficiency is dependent on type of drug and its characteristics [17], type and concentration of polymer inclusion of various additives [18][19][20][21][22][23].…”

Section: Introductionmentioning

confidence: 59%

Process and Parameters Affecting Drug Release Performance of Prepared Cross-Linked Alginate Hydrogel Beads for Ezetimibe

Reddy

Nagabhushanam

2017

Int J Pharm Pharm Sci

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Objective: The objective of this study was to formulate an oral sustained release delivery system of ezetimibe mucoadhesive beads by ionic gelation technique based on sodium alginate used as a hydrophilic carrier in combination with carbopol 934P which acts as a rate modifier.Methods: Microbeads of ezetimibe were prepared using an easy method of ionotropic gelation by little modification while in addition of drug. The prepared beads were characterised for mean particle size, entrapment efficiency, swelling capacity, and in vitro release. They were also subjected to various studies such as Fourier Transform Infrared Spectrophotometer (FTIR) Spectroscopy for drug polymer reaction, Scanning Electron Microscopy for surface morphology, and Differential Scanning Calorimetric Analysis to determine the physical state of the drug in the beads. Results:The microspheres of ezetimibe were formulated successfully. The addition of drug concentration gives higher drug loading and higher conc. of Alcl+3Conclusion: It can be concluded that beads produced by the sequential method had higher drug entrapment. Beads produced by simultaneous yields larger beads in diameter. The concept was cleared that drug release was dependent upon the quantity of polymer and increase in conc. of. aluminium chloride retarded the drug release in the sequential method. Prepared beads enhance the dissolution of ezetimibe and the oral bioavailability and also reduce the fluctuations in the oral bioavailability. yields small diameter beads and lower drug entrapment. Analysis of the release profiles showed that the data corresponds to zero order release and the diffusion-controlled mechanism as suggested by Higuchi concept.

show abstract

Shape optimization and characterization of polysaccharide beads prepared by ionotropic gelation

Cited by 50 publications

References 27 publications

Development of pH-sensitive tamarind seed polysaccharide–alginate composite beads for controlled diclofenac sodium delivery using response surface methodology

Development of pH-sensitive tamarind seed polysaccharide–alginate composite beads for controlled diclofenac sodium delivery using response surface methodology

Microencapsulation of probiotics using sodium alginate

Process and Parameters Affecting Drug Release Performance of Prepared Cross-Linked Alginate Hydrogel Beads for Ezetimibe

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