Shape memory supramolecular networks for the photoregulated adsorption and release of model molecules

Li, Jin; Cao, Yiping; You, Qingliang; Shi, Hui; He, Li; Wang, Juan; Ni, Congcong; Chen, Yong; Qian, Zhiyong

doi:10.1166/mex.2013.1128

Cited by 2 publications

(2 citation statements)

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“…Lastly, DNQ displays a photoinduced irreversible Wolff rearrangement reaction [79] with a loss of nitrogen, yielding an indene carboxylate [80]. In some examples, the light-induced release of embedded molecules from polymers containing photoswitches was only functional after grinding, probably due to low light penetration [81]. Thus, light/drug permeable materials such as hydrogels [82], small-sized polymer matrices such as nanoparticles/-capsules [83], vehicles with light-absorbing probes located at the particle surface [84,85], or water-soluble conjugates of drugs and photocleavable targeting constructs [86] may be more feasible approaches for light-triggered release systems.…”

Section: Light-responsive Materialsmentioning

confidence: 99%

Opportunities and Challenges of Switchable Materials for Pharmaceutical Use

Tuncaboylu

Wischke

2022

Pharmaceutics

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Switchable polymeric materials, which can respond to triggering signals through changes in their properties, have become a major research focus for parenteral controlled delivery systems. They may enable externally induced drug release or delivery that is adaptive to in vivo stimuli. Despite the promise of new functionalities using switchable materials, several of these concepts may need to face challenges associated with clinical use. Accordingly, this review provides an overview of various types of switchable polymers responsive to different types of stimuli and addresses opportunities and challenges that may arise from their application in biomedicine.

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Section: Light-responsive Materialsmentioning

confidence: 99%

Opportunities and Challenges of Switchable Materials for Pharmaceutical Use

Tuncaboylu

Wischke

2022

Pharmaceutics

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“…9 Several reports describe the combination of these functions for sustained, localized delivery of therapeutic agents and the eventual reduction of the SMP to biocompatible, nontoxic degradation products. [10][11][12][13][14][15][16][17][18][19][20] Triggered drug release from SMPs has also been achieved using ultrasound, [21][22][23] pH, 6 and photo-responsive 24 materials. In all these cases the drug is loaded into and subsequently released from the bulk SMP, which in some cases could alter the network morphology and consequently interfere with shape recovery.…”

Section: Introductionmentioning

confidence: 99%

Combined, independent small molecule release and shape memory via nanogel-coated thiourethane polymer networks

et al. 2016

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Drug releasing shape memory polymers (SMPs) were prepared from poly(thiourethane) networks that were coated with drug loaded nanogels through a UV initiated, surface mediated crosslinking reaction. Multifunctional thiol and isocyanate monomers were crosslinked through a step-growth mechanism to produce polymers with a homogeneous network structure that exhibited a sharp glass transition with 97% strain recovery and 96% shape fixity. Incorporating a small stoichiometric excess of thiol groups left pendant functionality for a surface coating reaction. Nanogels with diameter of approximately 10 nm bearing allyl and methacrylate groups were prepared separately via solution free radical polymerization. Coatings with thickness of 10–30 μm were formed via dip-coating and subsequent UV-initiated thiol-ene crosslinking between the SMP surface and the nanogel, and through inter-nanogel methacrylate homopolymerization. No significant change in mechanical properties or shape memory behavior was observed after the coating process, indicating that functional coatings can be integrated into an SMP without altering its original performance. Drug bioactivity was confirmed via in vitro culturing of human mesenchymal stem cells with SMPs coated with dexamethasone-loaded nanogels. This article offers a new strategy to independently tune multiple functions on a single polymeric device, and has broad application toward implantable, minimally invasive medical devices such as vascular stents and ocular shunts, where local drug release can greatly prolong device function.

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Shape memory supramolecular networks for the photoregulated adsorption and release of model molecules

Cited by 2 publications

References 0 publications

Opportunities and Challenges of Switchable Materials for Pharmaceutical Use

Opportunities and Challenges of Switchable Materials for Pharmaceutical Use

Combined, independent small molecule release and shape memory via nanogel-coated thiourethane polymer networks

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