Shape-memory collagen scaffold combined with hyaluronic acid for repairing intervertebral disc

Koo, Young Won; Lim, Chang Su; Darai, Anjani; Lee, JiUn; Kim, Won-Jin; Han, Inbo; Kim, GeunHyung

doi:10.1186/s40824-023-00368-9

Cited by 5 publications

(1 citation statement)

References 74 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In turn, the collagen-based SMHs exhibited outstanding chondrogenic activities and physical properties similar to a typical alginate construct in terms of water absorption, compressive properties, and shapememorability behavior. The treatment of the rat tail nucleotomy model with shape memory collagen-cryogel/HA alleviated mechanical allodynia, maintained a higher concentration of water content, and preserved the disc structure by restoring the matrix proteins [94]. Similarly, the silk fibroin-based cryogels were employed as implantable scaffolds for osteogenic differentiation and bone marrow recovery.…”

Section: Smhs For Tissue Regeneration Therapiesmentioning

confidence: 99%

Shape Memory Hydrogels for Biomedical Applications

Farrukh,

Nayab

2024

Gels

View full text Add to dashboard Cite

The ability of shape memory polymers to change shape upon external stimulation makes them exceedingly useful in various areas, from biomedical engineering to soft robotics. Especially, shape memory hydrogels (SMHs) are well-suited for biomedical applications due to their inherent biocompatibility, excellent shape morphing performance, tunable physiochemical properties, and responsiveness to a wide range of stimuli (e.g., thermal, chemical, electrical, light). This review provides an overview of the unique features of smart SMHs from their fundamental working mechanisms to types of SMHs classified on the basis of applied stimuli and highlights notable clinical applications. Moreover, the potential of SMHs for surgical, biomedical, and tissue engineering applications is discussed. Finally, this review summarizes the current challenges in synthesizing and fabricating reconfigurable hydrogel-based interfaces and outlines future directions for their potential in personalized medicine and clinical applications.

show abstract

Section: Smhs For Tissue Regeneration Therapiesmentioning

confidence: 99%

Shape Memory Hydrogels for Biomedical Applications

Farrukh,

Nayab

2024

Gels

View full text Add to dashboard Cite

show abstract

Wharton's jelly‐derived multifunctional hydrogels: New tools to promote intervertebral disc regeneration in vitro and ex vivo

Penolazzi,

Chierici,

Notarangelo

et al. 2024

J Biomedical Materials Res

View full text Add to dashboard Cite

The degeneration of intervertebral disc (IVD) is a disease of the entire joint between two vertebrae in the spine caused by loss of extracellular matrix (ECM) integrity, to date with no cure. The various regenerative approaches proposed so far have led to very limited successes. An emerging opportunity arises from the use of decellularized ECM as a scaffolding material that, directly or in combination with other materials, has greatly facilitated the advancement of tissue engineering. Here we focused on the decellularized matrix obtained from human umbilical cord Wharton's jelly (DWJ) which retains several structural and bioactive molecules very similar to those of the IVD ECM. However, being a viscous gel, DWJ has limited ability to retain ordered structural features when considered as architecture scaffold. To overcome this limitation, we produced DWJ‐based multifunctional hydrogels, in the form of 3D millicylinders containing different percentages of alginate, a seaweed‐derived polysaccharide, and gelatin, denatured collagen, which may impart mechanical integrity to the biologically active DWJ. The developed protocol, based on a freezing step, leads to the consolidation of the entire polymeric dispersion mixture, followed by an ionic gelation step and a freeze‐drying process. Finally, a porous, stable, easily storable, and suitable matrix for ex vivo experiments was obtained. The properties of the millicylinders (Wharton's jelly millicylinders [WJMs]) were then tested in culture of degenerated IVD cells isolated from disc tissues of patients undergoing surgical discectomy. We found that WJMs with the highest percentage of DWJ were effective in supporting cell migration, restoration of the IVD phenotype (increased expression of Collagen type 2, aggrecan, Sox9 and FOXO3a), anti‐inflammatory action, and stem cell activity of resident progenitor/notochordal cells (increased number of CD24 positive cells). We are confident that the DWJ‐based formulations proposed here can provide adequate stimuli to the cells present in the degenerated IVD to restart the anabolic machinery.

show abstract

Hydrogels in Gene Delivery Techniques for Regenerative Medicine and Tissue Engineering

Xu,

Zhang,

Zhu

et al. 2024

Macromolecular Bioscience

View full text Add to dashboard Cite

Hydrogels are three‐dimensional networks swollen with water. They are biocompatible, strong, moldable, and are emerging as a promising biomedical material for regenerative medicine and tissue engineering to deliver therapeutic gene. The excellent natural extracellular matrix simulation properties of hydrogels enable them to be co‐cultured with cells or enhance the expression of viral or non‐viral vectors. Its biocompatibility, high strength and degradation performance also make the action process of carriers in tissues more ideal, making it an ideal biomedical material. It has been shown that hydrogel‐based gene delivery technologies have the potential to play therapy‐relevant roles in organs such as bone, cartilage, nerve, skin, reproductive organs, and liver in animal experiments and preclinical trials. This paper reviews recent articles on hydrogels in gene delivery and explains the manufacture, applications, developmental timeline, limitations, and future directions of hydrogel‐based gene delivery techniques.This article is protected by copyright. All rights reserved

show abstract

Shape-memory collagen scaffold combined with hyaluronic acid for repairing intervertebral disc

Cited by 5 publications

References 74 publications

Shape Memory Hydrogels for Biomedical Applications

Shape Memory Hydrogels for Biomedical Applications

Wharton's jelly‐derived multifunctional hydrogels: New tools to promote intervertebral disc regeneration in vitro and ex vivo

Hydrogels in Gene Delivery Techniques for Regenerative Medicine and Tissue Engineering

Contact Info

Product

Resources

About