Shape-memory balloon offering simultaneous thermo/chemotherapies to improve anti-osteosarcoma efficacy

Ouchi, Sosuke; Niiyama, Eri; Sugo, Ken; Uto, Koichiro; Takenaka, Satoshi; Kikuchi, Akihiko; Ebara, Mitsuhiro

doi:10.1039/d1bm00780g

Cited by 7 publications

(4 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An elevation in temperature up to 57 °C was obtained by the application of alternating magnetic field on linear PCL‐film containing a large amount of MNPs of 46.1 wt%. [ 47 ] On the other hand, a surge of versatile surgical instrumentations such as flexible fetoscopes, a wide range of fetoscopic sheaths and lasers for coagulation, have greatly advanced the field of minimally invasive fetoscopic surgery. [ 48 ] Among which, laser‐based prenatal interventions are inherently well suited for minimally invasive surgeries.…”

Section: Resultsmentioning

confidence: 99%

Smart Shape‐Memory Polymeric String for the Contraction of Blood Vessels in Fetal Surgery of Sacrococcygeal Teratoma

Fulati

Uto

Iwanaga

et al. 2022

Adv Healthcare Materials

Self Cite

View full text Add to dashboard Cite

Shape-memory polymers (SMPs) are promising materials in numerous emerging biomedical applications owing to their unique shape-memory characteristics. However, simultaneous realization of high strength, toughness, stretchability while maintaining high shape fixity (R f ) and shape recovery ratio (R r ) remains a challenge that hinders their practical applications. Herein, a novel shape-memory polymeric string (SMP string) that is ultra-stretchable (up to 1570%), strong (up to 345 MPa), tough (up to 237.9 MJ m −3 ), and highly recoverable (R f averagely above 99.5%, R r averagely above 99.1%) through a facile approach fabricated solely by tetra-branched poly(𝝐-caprolactone) (PCL) is reported. Notably, the shape-memory contraction force (up to 7.97 N) of this SMP string is customizable with the manipulation of their energy storage capacity by adjusting the string thickness and stretchability. In addition, this SMP string displays a controllable shape-memory response time and demonstrates excellent shape-memory-induced contraction effect against both rigid silicone tubes and porcine carotids. This novel SMP string is envisioned to be applied in the contraction of blood vessels and resolves the difficulties in the restriction of blood flow in minimally invasive surgeries such as fetoscopic surgery of sacrococcygeal teratoma (SCT).

show abstract

Section: Resultsmentioning

confidence: 99%

Smart Shape‐Memory Polymeric String for the Contraction of Blood Vessels in Fetal Surgery of Sacrococcygeal Teratoma

Fulati

Uto

Iwanaga

et al. 2022

Adv Healthcare Materials

Self Cite

View full text Add to dashboard Cite

show abstract

“…Shape-memory polymers (SMPs) are representative smart polymers and have been extensively studied in the past few decades owing to their unique capability of recovering their permanent original shapes from a temporarily fixed shape when actuated by various external stimuli, such as heat [ 1 , 2 , 3 ], light [ 4 , 5 ], lasers [ 6 , 7 ], and magnetic fields [ 8 , 9 ]. Immense efforts have been dedicated to exploring this unique shape-memory property and its induced shape-memory motions, such as bending, stretching, lifting, and grasping, in vast applications, including soft robotics, artificial muscles, actuators and biomedical devices [ 10 , 11 , 12 , 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Influences of Crystallinity and Crosslinking Density on the Shape Recovery Force in Poly(ε-Caprolactone)-Based Shape-Memory Polymer Blends

2022

Self Cite

View full text Add to dashboard Cite

Shape-memory polymers (SMPs) show great potential in various emerging applications, such as artificial muscles, soft actuators, and biomedical devices, owing to their unique shape recovery-induced contraction force. However, the factors influencing this force remain unclear. Herein, we designed a simple polymer blending system using a series of tetra-branched poly(ε-caprolactone)-based SMPs with long and short branch-chain lengths that demonstrate decreased crystallinity and increased crosslinking density gradients. The resultant polymer blends possessed mechanical properties manipulable across a wide range in accordance with the crystallinity gradient, such as stretchability (50.5–1419.5%) and toughness (0.62–130.4 MJ m−3), while maintaining excellent shape-memory properties. The experimental results show that crosslinking density affected the shape recovery force, which correlates to the SMPs’ energy storage capacity. Such a polymer blending system could provide new insights on how crystallinity and crosslinking density affect macroscopic thermal and mechanical properties as well as the shape recovery force of SMP networks, improving design capability for future applications.

show abstract

“…Materials. L-Lysine diisocyanate ethyl ester (>96%, LDI) was obtained from Actu-All Chemicals, trimethylene carbonate (99%, TMC) was provided by Huizhou Foryou Medical Devices, εcaprolactone (99%, CL) and 2-hyrdroxyethyl acrylate 28 were obtained from Alfa Aesar, diphenyl (2,4,6-trimethylbezoyl) phosphine oxide (TPO) and calcium hydride (CaH 2 ) were obtained from Sigma-Aldrich, tetrahydrofuran (anhydrous, ≥99%, THF), tin 22 2-ethylhexanoate (92.5%, Sn(II)Oct), methanol (99.5%), triethylene glycol (≥99%, TEG), and toluene (≥99.8%, anhydrous) were obtained from Merck, 2-(2-ethoxy-ethoxy) ethyl acrylate (EOEOEA) was provided by TCI Chemicals, and chloroform (98%, CHCl 3 ) was obtained from VWR. CL was dried for 12 h over calcium hydride and distilled under reduced pressure.…”

Section: Methodsmentioning

confidence: 99%

“…The shape memory properties of polycaprolactone (PCL), together with its biocompatibility and biodegradability, have motivated an increasing number of researchers to explore the macromolecular design for modulating the shape recovery (time and temperature, which trigger the response). − Notably, here, we use the term biodegradability, although PCL has been shown to be capable of both enzymatic biodegradation and hydrolytic degradation . Most of the approaches include covalently cross-linked low molecular weight PCL, where the cross-links are indispensable to endow the material with a shape memory effect.…”

Section: Introductionmentioning

confidence: 99%

Digital Light Processing Resins with Programmable Shape Memory for Biomedical Applications

Aldana,

Kuhnt,

Marroquin Garcia

et al. 2024

Biomacromolecules

View full text Add to dashboard Cite

The creation of biodegradable and biocompatible shape memory polymers amenable to biofabrication techniques remains a challenge. The ability to create shape-changing biodegradable objects that are triggered at body temperature opens up possibilities in tissue engineering, minimally invasive surgery, and actuating bioimplants. Merging Digital Light Processing (DLP) printing with shape memory polymers brings us closer to new smart biomedical outcomes. Previously, we developed a poly(caprolactone-co-trimethylenecarbonate) urethane acrylate resin for the DLP fabrication of biodegradable 3D objects. In further studies, we observed that some of these resins possessed shape memory properties, triggered by body temperature (37 °C). In this subsequent study, we explored the shape memory properties and tunability of this resin family via changes in copolymer composition, molecular weight, and identity of the acrylate end-capping unit. We found that we could create a library of shape memory resins, amenable to DLP printing, which allowed the creation of shape-actuating structures with some tunability over the speed of shape memory and mechanical properties. We observed that increased mole fraction of caprolactone in the copolymer and increased molecular weight of the polymer led to a decrease in speed of the shape memory switch. Furthermore, we observed a trade-off between the composition and the end-capping moiety on the mechanical properties of the polymers. These polymeric resins were able to be processed into shapes that were able to perform work, including the release of cargo and grabbing/lifting of an object. This platform now provides a way to tune the speed and mechanical properties of a shape memory DLP object created from common and scalable polymerization techniques. This work ultimately provides a new platform to develop customizable and biodegradable devices capable of actuating and delivery devices for numerous biomedical applications.

show abstract

Shape-memory balloon offering simultaneous thermo/chemotherapies to improve anti-osteosarcoma efficacy

Abstract: This paper proposes a shape-memory balloon (SMB) to improve bone cement injection efficiency and postoperative thermo/chemotherapy for bone tumors.

Cited by 7 publications

References 40 publications

Smart Shape‐Memory Polymeric String for the Contraction of Blood Vessels in Fetal Surgery of Sacrococcygeal Teratoma

Smart Shape‐Memory Polymeric String for the Contraction of Blood Vessels in Fetal Surgery of Sacrococcygeal Teratoma

Influences of Crystallinity and Crosslinking Density on the Shape Recovery Force in Poly(ε-Caprolactone)-Based Shape-Memory Polymer Blends

Digital Light Processing Resins with Programmable Shape Memory for Biomedical Applications

Contact Info

Product

Resources

About