Shape fidelity, mechanical and biological performance of 3D printed polycaprolactone-bioactive glass composite scaffolds

Baier, Raúl Vallejos; Raggio, José I. Contreras; Giovanetti, Carola Millán; Palza, Humberto; Burda, Iurii; Terrasi, Giovanni P.; Weisse, Bernhard; Freitas, Gilberto Siqueira De; Nyström, Gustav; Vivanco, Juan; Aiyangar, Ameet

doi:10.1016/j.msec.2021.112540

Cited by 14 publications

(13 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results of these studies also varied depending on the glass composition and particle size. Despite the significance of the improvement in bioactivity and cell proliferation, PCL scaffolds loaded with bioactive glass showed a significant reduction in mechanical properties compared to pure PCL scaffolds [82]. However, a recent study showed that 3D-printed PCL-bioactive glass composites exhibited mechanical properties and osteoconductive behavior similar to those of human trabecular bone.…”

Section: Thermoplastic Polymer/bioactive Glass Compositementioning

confidence: 97%

See 1 more Smart Citation

Can 3D-Printed Bioactive Glasses Be the Future of Bone Tissue Engineering?

et al. 2022

View full text Add to dashboard Cite

According to the Global Burden of Diseases, Injuries, and Risk Factors Study, cases of bone fracture or injury have increased to 33.4% in the past two decades. Bone-related injuries affect both physical and mental health and increase the morbidity rate. Biopolymers, metals, ceramics, and various biomaterials have been used to synthesize bone implants. Among these, bioactive glasses are one of the most biomimetic materials for human bones. They provide good mechanical properties, biocompatibility, and osteointegrative properties. Owing to these properties, various composites of bioactive glasses have been FDA-approved for diverse bone-related and other applications. However, bone defects and bone injuries require customized designs and replacements. Thus, the three-dimensional (3D) printing of bioactive glass composites has the potential to provide customized bone implants. This review highlights the bottlenecks in 3D printing bioactive glass and provides an overview of different types of 3D printing methods for bioactive glass. Furthermore, this review discusses synthetic and natural bioactive glass composites. This review aims to provide information on bioactive glass biomaterials and their potential in bone tissue engineering.

show abstract

Section: Thermoplastic Polymer/bioactive Glass Compositementioning

confidence: 97%

“…Owing to its good rheology and viscoelastic properties, it is specifically suitable for PDM-based 3D printing of scaffolds. However, due to its insolubility in water, PCL inks were prepared by dissolving PCL in an organic solvents, such as chloroform or dichloromethane [82].…”

Section: Thermoplastic Polymer/bioactive Glass Compositementioning

confidence: 99%

Can 3D-Printed Bioactive Glasses Be the Future of Bone Tissue Engineering?

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Baier et al [ 151 ] prepared a 3D PCL/45S5 BG composite scaffolds by direct ink writing at high temperature. The raw composite pellets were fabricated by solvent casting.…”

Section: Manufacturing Processmentioning

confidence: 99%

A Review on Manufacturing Processes of Biocomposites Based on Poly(α-Esters) and Bioactive Glass Fillers for Bone Regeneration

et al. 2023

View full text Add to dashboard Cite

The incorporation of bioactive and biocompatible fillers improve the bone cell adhesion, proliferation and differentiation, thus facilitating new bone tissue formation upon implantation. During these last 20 years, those biocomposites have been explored for making complex geometry devices likes screws or 3D porous scaffolds for the repair of bone defects. This review provides an overview of the current development of manufacturing process with synthetic biodegradable poly(α-ester)s reinforced with bioactive fillers for bone tissue engineering applications. Firstly, the properties of poly(α-ester), bioactive fillers, as well as their composites will be defined. Then, the different works based on these biocomposites will be classified according to their manufacturing process. New processing techniques, particularly additive manufacturing processes, open up a new range of possibilities. These techniques have shown the possibility to customize bone implants for each patient and even create scaffolds with a complex structure similar to bone. At the end of this manuscript, a contextualization exercise will be performed to identify the main issues of process/resorbable biocomposites combination identified in the literature and especially for resorbable load-bearing applications.

show abstract

“…However, several studies have reported that its incorporation in polymer-based scaffolds decreases the mechanical strength and causes frequent fractures or cracks, which compromises the use of such composite scaffolds for load-bearing applications [ 44 , 45 , 46 ]. This has been explained by the poor interfacial adhesion, with the bioglass particles acting as defects in the polymer matrix [ 47 ]. Moreover, most PCL–bioglass blends are prepared using toxic solvents, such as chloroform and dichloromethane, to dissolve the polymeric material [ 47 , 48 ].…”

Section: Introductionmentioning

confidence: 99%

“…This has been explained by the poor interfacial adhesion, with the bioglass particles acting as defects in the polymer matrix [ 47 ]. Moreover, most PCL–bioglass blends are prepared using toxic solvents, such as chloroform and dichloromethane, to dissolve the polymeric material [ 47 , 48 ].…”

Section: Introductionmentioning

confidence: 99%

Novel 3D Bioglass Scaffolds for Bone Tissue Regeneration

et al. 2022

View full text Add to dashboard Cite

The design of scaffolds with optimal biomechanical properties for load-bearing applications is an important topic of research. Most studies have addressed this problem by focusing on the material composition and not on the coupled effect between the material composition and the scaffold architecture. Polymer–bioglass scaffolds have been investigated due to the excellent bioactivity properties of bioglass, which release ions that activate osteogenesis. However, material preparation methods usually require the use of organic solvents that induce surface modifications on the bioglass particles, compromising the adhesion with the polymeric material thus compromising mechanical properties. In this paper, we used a simple melt blending approach to produce polycaprolactone/bioglass pellets to construct scaffolds with pore size gradient. The results show that the addition of bioglass particles improved the mechanical properties of the scaffolds and, due to the selected architecture, all scaffolds presented mechanical properties in the cortical bone region. Moreover, the addition of bioglass indicated a positive long-term effect on the biological performance of the scaffolds. The pore size gradient also induced a cell spreading gradient.

show abstract

Shape fidelity, mechanical and biological performance of 3D printed polycaprolactone-bioactive glass composite scaffolds

Cited by 14 publications

References 65 publications

Can 3D-Printed Bioactive Glasses Be the Future of Bone Tissue Engineering?

Can 3D-Printed Bioactive Glasses Be the Future of Bone Tissue Engineering?

A Review on Manufacturing Processes of Biocomposites Based on Poly(α-Esters) and Bioactive Glass Fillers for Bone Regeneration

Novel 3D Bioglass Scaffolds for Bone Tissue Regeneration

Contact Info

Product

Resources

About