Shape fabrication of millimeter-sized metal-containing carboxymethyl cellulose hollow capsules

Bourlinos, A. B.; Petridis, Dimitris

doi:10.1039/b208458a

Cited by 12 publications

(6 citation statements)

References 10 publications

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“…Nagai et al developed poly(dimethylsiloxane)-encapsulated poly(amic acid) capsules with a diameter of 0.5–5 mm by injecting poly(dimethylsiloxane) into poly(amic acid) spheres and curing the resulting capsules at high temperature. Bourlinos and Petridis developed millimeter-sized polymeric capsules by dropwise adding an aqueous carboxymethyl cellulose solution into an n -butanol solution with copper or iron salt. Recently, millimeter-sized capsules were prepared using liquid marbles by dropwise adding a trimethylolpropane trimethacrylate monomer droplet on superamphiphobic powders, rolling it to form liquid marbles, injecting water droplet into the liquid marbles, and irradiating them by visible light .…”

Section: Introductionmentioning

confidence: 99%

Electrosprayed Soft Capsules of Millimeter Size for Specifically Delivering Fish Oil/Nutrients to the Stomach and Intestines

Wang

Wei

et al. 2020

ACS Appl. Mater. Interfaces

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Contrasting to the traditional centimeter-sized soft capsules that are difficult to swallow or micro/nanometer-sized soft capsules that suffer from limited loading capacity for fish oil/nutrients and lowered stability, the millimeter-sized soft capsules with good enough stability could be a potential solution in solving these problems. Herein, we report millimeter-sized soft core−shell capsules of 0.42−1.85 mm with an inner diameter of 0.36−1.75 mm, for fish oil/nutrients, obtained through an electrospray approach upon optimization of different fabrication parameters such as applied voltage, sodium alginate concentration, shell/core feeding rate ratio, times of feeding rate, and types of coaxial needles. Further in vitro and in vivo studies reveal that the resulting soft capsules were apparently weakened and became mechanically destructive in the simulated small intestine solution and were totally destroyed in the simulated small intestine solution if they were first treated in the simulated stomach solution but not in the simulated stomach solution, which makes the millimeter-sized capsules useful as containers for specific delivery of fish oils and lipophilic nutrients to the stomach and intestines with excellent in vivo bioavailability (>90%). The whole fabrication approach is very facile with no complicated polymer modification and formulations involved, which endows the resulting soft capsules with broad application prospect in food and drug industries.

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Section: Introductionmentioning

confidence: 99%

Electrosprayed Soft Capsules of Millimeter Size for Specifically Delivering Fish Oil/Nutrients to the Stomach and Intestines

Wang

Wei

et al. 2020

ACS Appl. Mater. Interfaces

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“…Sodium carboxymethyl cellulose (CMC) (Scheme ), a nontoxic and biodegradable cellulose derivative, has been used widely in biotechnology, , medicine, , hydrogels, − and other materials. − Recently, CMC has been used as a good stabilizer in the synthesis of metal nanoparticles in an aqueous medium. − However, reducing agents such as NaBH 4 were still used in these studies. More recently, cellulose was used as the reducing regent in Au(III)−Au(0) reduction and also as a moderately efficient template for the formation of various micrometer-sized gold particles .…”

Section: Introductionmentioning

confidence: 99%

Controllable Aggregation and Reversible pH Sensitivity of AuNPs Regulated by Carboxymethyl Cellulose

et al. 2009

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A pH-sensitive gold nanoparticle-cysteamine/carboxymethyl cellulose (Au-CA/CMC) dispersion system was prepared by a simple approach. Gold nanoparticles (AuNPs) were first synthesized by directly reducing chloroauric acid (HAuCl(4)) with sodium carboxymethyl cellulose (CMC). Then the AuNPs were decorated by an electrostatic compound of cysteamine hydrochloride (CA) and sodium carboxymethyl cellulose (CMC) through ligand exchange to get the assembly of Au-CA/CMC. The Au-CA/CMC dispersion system exhibits strongly reversible pH-responsive behavior with the aggregation of AuNPs caused by the combined action of the chain conformation change of CMC and electrostatic interactions between CA and CMC at different pH values. Finally, the reversible aggregation mechanism of AuNPs in the Au-CA/CMC dispersion system has been investigated by transmission electron microscopy (TEM) and ultraviolet-visible spectroscopy (UV-vis spectroscopy). This study provides a new method to fabricate a stimuli-responsive system free from complicated organic synthesis without using a toxic reducing agent.

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“…Petridis et al reported that dropwise addition of CMC solution to a Cu or Fe salt in n-butanol leads to self-assembled, permeable, millimeter-sized metal-ion-derivatized CMC hollow capsules. 30 Herein, we report a simple and convenient approach that generates nanocomposites at room temperature in aqueous medium, encompassing various metal salts such as Cu, In, Fe, and Ag, and these materials may find potential applications such as in antibacterial, antifungal coatings, food packaging, and biomedical devices.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Thermally Stable Carboxymethyl Cellulose/Metal Biodegradable Nanocomposites for Potential Biological Applications

2007

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A green approach is described that generates bulk quantities of nanocomposites containing transition metals such as Cu, Ag, In, and Fe at room temperature using a biodegradable polymer, carboxymethyl cellulose (CMC), by reacting respective metal salts with the sodium salt of CMC in aqueous media. These nanocomposites exhibit broader decomposition temperatures when compared with control CMC, and Ag-based CMC nanocomposites exhibit a luminescent property at longer wavelengths. The noble metals such as Au, Pt, and Pd do not react at room temperature with aqueous solutions of CMC, but do so rapidly under microwave irradiation (MW) conditions at 100 degrees C. This environmentally benign approach, which provides facile entry to the production of multiple shaped noble nanostructures without using any toxic reducing agent such as sodium borohydride (NaBH4), hydroxylamine hydrochloride, and so forth, and/or a capping/surfactant agent, and which uses a benign biodegradable polymer CMC, could find widespread technological and medicinal applications. The ensuing nanocomposites derived at room temperature and MW conditions were characterized using scanning electron microscopy, transmission electron microscopy, infrared spectroscopy, UV-visible spectroscopy, X-ray mapping, energy-dispersive analysis, and thermogravimetric analysis.

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Shape fabrication of millimeter-sized metal-containing carboxymethyl cellulose hollow capsules

Abstract: Dropwise addition of an aqueous carboxymethyl cellulose solution to a solution of a copper or iron salt in n-butanol, leads to self-assembled, permeable millimeter sized metal-ion derivatized carboxymethyl cellulose hollow capsules of uniform dimensions and different morphologies.

Cited by 12 publications

References 10 publications

Electrosprayed Soft Capsules of Millimeter Size for Specifically Delivering Fish Oil/Nutrients to the Stomach and Intestines

Electrosprayed Soft Capsules of Millimeter Size for Specifically Delivering Fish Oil/Nutrients to the Stomach and Intestines

Controllable Aggregation and Reversible pH Sensitivity of AuNPs Regulated by Carboxymethyl Cellulose

Synthesis of Thermally Stable Carboxymethyl Cellulose/Metal Biodegradable Nanocomposites for Potential Biological Applications

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