Shape-dependent antibacterial effects of non-cytotoxic gold nanoparticles

Penders, Jelle; Stolzoff, Michelle; Hickey, Daniel; Andersson, Martin; Webster, Thomas J.

doi:10.2147/ijn.s124442

Cited by 123 publications

(95 citation statements)

References 53 publications

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“…No proinflammatory cytokines secretion, such as necrosis factor tumor alpha (TNF-), was detected in a study with macrophage cells; these results emphasize that AuNPs are not cytotoxic or immunogenic but are biocompatible, corroborating their excellent potential in the areas of nanoimmunology, nanobiotechnology, and nanomedicine [12]. On the other hand, good antibacterial activity has been demonstrated against various pathogenic bacteria [13,14].…”

Section: Journal Of Nanomaterialsmentioning

confidence: 79%

Synthesis and Bactericidal Properties of Hyaluronic Acid Doped with Metal Nanoparticles

Cárdenas-Triviño

Ruiz-Parra

Vergara-González

et al. 2017

Journal of Nanomaterials

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A study on the nanoparticles size and the antibacterial properties of hyaluronic acid (HA) doped with nanoparticles is reported. Nanoparticles from gold, silver, copper, and silver palladium with HA support were performed. The solvated metal atom dispersion (SMAD) method with 2-propanol and HA was used. High-resolution transmission electron microscopy (HRTEM), infrared spectroscopy (FT-IR), and thermogravimetric analysis (TGA) were conducted. The average sizes of nanoclusters were as follows: HA-Au = 17.88 nm; HA-Ag = 50.41 nm; HA-Cu = 13.33 nm; and HA-AgPd = 33.22 nm. The antibacterial activity of solutions and films containing nanoparticles against American Type Culture Collection (ATCC) bacterial strains Escherichia coli (EC), Staphylococcus aureus (SA), Staphylococcus epidermidis (SE), and Pseudomonas aeruginosa (PA) was determined. Inhibition was observed for HA-Ag, HA-Cu, and HA-AgPd. Toxicological tests were performed in rats that were injected intraperitoneally with two concentrations of gold, copper, silver, and silver-palladium nanoparticles. No alterations in hepatic parameters, including ALT (alanine aminotransferase), GGT (gamma-glutamyl transpeptidase) bilirubin, and albumin, were observed after 14 days. These films could be used as promoters of skin recovery and Grades I and II cutaneous burns and as scaffolds.

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Section: Journal Of Nanomaterialsmentioning

confidence: 79%

Synthesis and Bactericidal Properties of Hyaluronic Acid Doped with Metal Nanoparticles

Cárdenas-Triviño

Ruiz-Parra

Vergara-González

et al. 2017

Journal of Nanomaterials

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“…Along with delivery strategy, conjugating nanoparticles with antibodies against tumour markers (such as tumour necrosis factor (TNF) or epidermal growth factor receptor)as the active delivery methodhas more reliability and efficiency [59]. This technique is not only applied for destroying tumour cells, but also can be used for selective damaging of microbial agents such as bacteria or protozoa (Figure 1).…”

Section: Targeted Drug Delivery Based On Gold Nanoparticlementioning

confidence: 99%

“…This technique is not only applied for destroying tumour cells, but also can be used for selective damaging of microbial agents such as bacteria or protozoa (Figure 1). In conjunction with the application of AuNPs in cancer biology, these particles are now used for the detection of microbial cells and their behaviours [59]. The fact of the matter is that labelling microbial cells and their metabolites using AuNP can provide qualitative assessment of these cells and their interactions of pharmaceutical nanoparticles [60].…”

Section: Targeted Drug Delivery Based On Gold Nanoparticlementioning

confidence: 99%

Using gold nanoparticles in diagnosis and treatment of melanoma cancer

Bagheri

Yasemi

Safaie-Qamsari

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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Several studies have been devoted to clear functionalization of gold nanoparticles (AuNPs) in different fields such as cellular and molecular biology, microbiology, immunology and physiology. In line with the high diagnostic value of AuNPs, its therapeutic application has been intensively developed in tumour therapy, in recent years. One of the best clinical applications of AuNPs is its use in targeted delivery of anti-cancer drugs. Recent studies have focused on the application of AuNPs to treat melanoma - a malignant neoplasm sourced from melanocytes skin cells - with poor prognosis in advanced stages. Furthermore, early diagnosis can be successfully achieved through utilizing this technique even at early stages with localized distribution. Herein, this study details the previous researches focusing on the use of AuNPs as a novel diagnostic and therapeutic option in management of melanoma.

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“…[3][4][5] Large body of research has been conducted to explore the antibacterial activity of GNP of different shapes and physiochemical properties toward different bacterial strains, nevertheless the findings are conflicting. [6][7][8][9][10][11] Acne vulgaris is a chronic skin inflammatory disease; it results in comedones or severe inflammatory lesions in the face, back, and chest. The pathophysiology of acne includes abnormal proliferation and differentiation of keratinocytes, increased sebum production, and hyperproliferation of microorganisms that are part of the normal skin flora, mainly Propionibacterium acnes, Staphylococcus aureus, and S. epidermidis.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial activity of gold nanorods against <em>Staphylococcus aureus</em> and<em> Propionibacterium acnes</em>: misinterpretations and artifacts

Mahmoud

Alkilany

Khalil

et al. 2017

IJN

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The antibacterial activity of gold nanorod (GNR) suspensions of different surface functionalities was investigated against standard strains of Staphylococcus aureus and Propionibacterium acnes , taking into consideration two commonly “overlooked” factors: the colloidal stability of GNR suspensions upon mixing with bacterial growth media and the possible contribution of “impurities/molecules” in GNR suspensions to the observed antibacterial activity. The results demonstrated that cationic polyallylamine hydrochloride (PAH)-GNR were severely aggregated when exposed to bacterial growth media compared to other GNR suspensions. In addition, the free cetyltrimethylammonium bromide (CTAB) present in GNR suspensions is most likely the origin of the observed antibacterial activity. However, the antibacterial activity of GNR themselves could not be excluded. Probing these two critical control studies prevents misinterpretations and artifacts of the antibacterial activity of nanoparticles. Unfortunately, these practices are usually ignored in the published studies and may explain the significant conflicting results. In addition, this study indicates that GNR could be a promising candidate for the treatment of skin follicular diseases such as acne vulgaris.

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Shape-dependent antibacterial effects of non-cytotoxic gold nanoparticles

Cited by 123 publications

References 53 publications

Synthesis and Bactericidal Properties of Hyaluronic Acid Doped with Metal Nanoparticles

Synthesis and Bactericidal Properties of Hyaluronic Acid Doped with Metal Nanoparticles

Using gold nanoparticles in diagnosis and treatment of melanoma cancer

Antibacterial activity of gold nanorods against <em>Staphylococcus aureus</em> and<em> Propionibacterium acnes</em>: misinterpretations and artifacts

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