Shamimin: A New Flavonol<i>C</i>-Glycoside from Leaves of<i>Bombax ceiba</i>*

Faizi, Shaheen; Ali, M. Syed

doi:10.1055/s-2006-960796

Cited by 41 publications

(25 citation statements)

References 1 publication

(1 reference statement)

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“…Pharmacologically the plant has been reported to have hepatic protective (Chiu et al , 1992) and hypotensive activity (Saleem et al , 1999), as well as anti-inflammatory effect (Lin et al , 1992). Phytochemical investigation has revealed the presence of a naphthol, naphthoquinones, polysaccharides, anthocyanins, shamimin, and lupeol in this plant (Seshadri et al , 1971;1973;Sankaram et al , 1981;Faizi and Ali, 1999).…”

Section: Introductionmentioning

confidence: 99%

Antiangiogenic activity of lupeol from Bombax ceiba

You

Nam

Kim

et al. 2003

Phytotherapy Research

111

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In the search for antiangiogenic agents from medicinal plants used in Vietnam, a methanol extract of the stem barks of Bombax ceiba was found to exhibit a significant antiangiogenic activity on in vitro tube formation of human umbilical venous endothelial cells (HUVEC). Bioactivity-guided fractionation and isolation carried out on this extract afforded lupeol as an active principle. At 50 and 30 microg/mL lupeol showed a marked inhibitory activity on HUVEC tube formation while it did not affect the growth of tumor cell lines such as SK-MEL-2, A549, and B16-F10 melanoma.

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Section: Introductionmentioning

confidence: 99%

Antiangiogenic activity of lupeol from Bombax ceiba

You

Nam

Kim

et al. 2003

Phytotherapy Research

111

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“…Mangiferin has been isolated directly from the fresh leaves of Bombax ceiba; 1,2 however, its structure was erroneously described as flavonol-C-glucoside (shamimin), which was revised as xanthone-C-glucoside (1). 3 It has been documented in the literature that xanthone-C-glucosides are more closely related to flavonoids than to xanthones.…”

Section: Introductionmentioning

confidence: 99%

Temperature and solvent dependent NMR studies on mangiferin and complete NMR spectral assignments of its acyl and methyl derivatives

Faizi

Zikr-ur-Rehman

Ali

et al. 2006

Magnetic Reson in Chemistry

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By employing concerted 1 and 2D NMR techniques, exact NMR spectral assignments have been made of the acyl (2-7) and methyl (8 and 9) derivatives of mangiferin (1) isolated from the leaves of Bombax ceiba. Derivatives 2, 8 and 9 have been reported in literature, while 3-7 represent new compounds. The acetates 2 and 3 were found to be unstable and were converted into the same penta-acetate 4 at room temperature. Extensive NMR studies on mangiferin (1) and its derivatives showed that H-4 exchanges with deuterium of the solvent molecule more easily. This exchange under acidic conditions occurred at that position (C-4) where electrophilic substitution reactions can easily take place. This is the first report describing the exchange of C-4 proton of mangiferin (1), or any other xanthone, with deuterium of solvent molecules.

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“…[4][5][6] There is a considerable interest in the antioxidant and free radical scavanging properties of medicinal plants and compounds isolated from them 7) particularly polyphenols which are a broad family of naturally occurring physiologically active nutrients. Xanthones closely related to the polyphenol family, have a remarkable effect on cardiovascular system, are antibiotic, antiviral, anti-inflammatory and also includes some of the most powerful natural antioxidants.…”

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confidence: 99%

“…10,11) Various parts of B. ceiba have been claimed to cure chronic inflammation without any pharmacological studies, 12) therefore it was subjected to anti-inflammatory and analgesic testing. The present investigation on the extracts of leaves of the plant were subjected to bioassay monitored fractionation 4) which resulted in the isolation of mangiferin in substantial amounts possessing promising antioxidant and analgesic activities.…”

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confidence: 99%

Analgesic and Antioxidant Activity of Mangiferin and Its Derivatives: the Structure Activity Relationship

Dar

Faizi

Naqvi

et al. 2005

Biological & Pharmaceutical Bulletin

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225

163

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Mangiferin, 2-b b-D-glucopyranosyl-1,3,6,7-tetrahydroxy-9H-xanthen-9-one, obtained directly from methanolic extracts of Bombax ceiba leaves in substantial amounts demonstrated strong antioxidant activity (EC 50 5.8؎0.96 m mg/ml or 13.74 m mM) using DPPH assay comparable to rutin, commonly used as antioxidant for medical purposes. The acetyl and cinnamoyl derivatives were found to be less active than mangiferin whereas, methyl and 3,6,7-trimethylether tetraacetate derivatives were inactive implying that for antioxidant activity, free hydroxyl groups and catechol moiety are essential. Moreover, mangiferin showed hepatoprotective activity against carbon tetrachloride induced liver injury further supporting the free radical scavenging property in the in vivo system. Additionally, plant extracts and mangiferin failed to exhibit acute anti-inflammatory activity whereas, it displayed significant analgesic effect in acetic acid-induced writhing and hot plate tests in mice. Using naloxone, it was revealed that plant extracts induced analgesia was independent of opioid receptor, whereas, mangiferin demonstrated significant interaction with it at peripheral site with a slight contribution at the neuronal level.

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Shamimin: A New FlavonolC-Glycoside from Leaves ofBombax ceiba*

Cited by 41 publications

References 1 publication

Antiangiogenic activity of lupeol from Bombax ceiba

Antiangiogenic activity of lupeol from Bombax ceiba

Temperature and solvent dependent NMR studies on mangiferin and complete NMR spectral assignments of its acyl and methyl derivatives

Analgesic and Antioxidant Activity of Mangiferin and Its Derivatives: the Structure Activity Relationship

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