Shaking the myth: Body mass, aggression, steroid hormones, and social dominance in wild house mouse

Hiadlovská, Zuzana; Mikula, Ondřej; Macholán, Miloš; Hamplova, P.; Bímová, Barbora Vošlajerová; Daniszová, Kristina

doi:10.1016/j.ygcen.2015.09.033

Cited by 27 publications

(43 citation statements)

References 134 publications

(54 reference statements)

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“…Dominant alpha males of many species also have higher levels of testosterone and cortisol that may be physiologically damaging (Gesquiere et al, 2011;Higham, Heistermann, & Maestripieri, 2012;Mendonça-Furtado et al, 2014;Sapolsky, 2005). There is some evidence that more dominant mice may have elevated testosterone and corticosterone, although these findings vary depending upon social context, how dominance is assessed and other paradigmatic features (Bronson, 1973;Ely & Henry, 1978;Haemisch et al, 1994;Hiadlovsk a et al, 2015;Oyegbile & Marler, 2005;Selmanoff, Goldman, & Ginsburg, 1977;Zielinski & Vandenbergh, 1993). We propose that in our study, the mice that lost alpha status were physiologically no longer capable of maintaining their social position, although this hypothesis remains to be tested.…”

Section: Formation and Maintenance Of Social Hierarchiesmentioning

confidence: 68%

Temporal dynamics of social hierarchy formation and maintenance in male mice

2016

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Section: Formation and Maintenance Of Social Hierarchiesmentioning

confidence: 68%

Temporal dynamics of social hierarchy formation and maintenance in male mice

2016

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“…This raises a new question: What is unique about the Mmd subspecies that gives it an Abp -region architecture different from those we found in the other taxa we studied? The answer may lie in studies showing significantly different behavior patterns between Mmd and Mmm mice, such as aggression (Ganem 2012; Hiadlovska et al 2015). However, this will require additional work to correlate the Abp genome with specific behaviors using tools such as congenic and transgenic mouse lines (Laukaitis et al 1997; Chung et al 2017).…”

Section: Discussionmentioning

confidence: 99%

Analysis of Copy Number Variation in the Abp Gene Regions of Two House Mouse Subspecies Suggests Divergence during the Gene Family Expansions

Pezer

Chung

Karn

et al. 2017

Genome Biology and Evolution

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The Androgen-binding protein (Abp) gene region of the mouse genome contains 64 genes, some encoding pheromones that influence assortative mating between mice from different subspecies. Using CNVnator and quantitative PCR, we explored copy number variation in this gene family in natural populations of Mus musculus domesticus (Mmd) and Mus musculus musculus (Mmm), two subspecies of house mice that form a narrow hybrid zone in Central Europe. We found that copy number variation in the center of the Abp gene region is very common in wild Mmd, primarily representing the presence/absence of the final duplications described for the mouse genome. Clustering of Mmd individuals based on this variation did not reflect their geographical origin, suggesting no population divergence in the Abp gene cluster. However, copy number variation patterns differ substantially between Mmd and other mouse taxa. Large blocks of Abp genes are absent in Mmm, Mus musculus castaneus and an outgroup, Mus spretus, although with differences in variation and breakpoint locations. Our analysis calls into question the reliance on a reference genome for interpreting the detailed organization of genes in taxa more distant from the Mmd reference genome. The polymorphic nature of the gene family expansion in all four taxa suggests that the number of Abp genes, especially in the central gene region, is not critical to the survival and reproduction of the mouse. However, Abp haplotypes of variable length may serve as a source of raw genetic material for new signals influencing reproductive communication and thus speciation of mice.

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“…Rather, both subspecies adopt different exploratory strategies reflecting overall ontogenetic, physiological and social arrangements that may differ in both subspecies (Hiadlovská et al. ). Although it is premature to speculate about impacts of different explorative strategies of both sexes on the population dynamics of the two mouse subspecies as well as on their secondary contact, our results also suggest that females may have sufficient motivation for emigration and dispersal from the natal deme.…”

Section: Discussionmentioning

confidence: 99%

Female House Mice do not Differ in Their Exploratory Behaviour from Males

et al. 2016

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Dispersal is an important ecological trait affecting genetic variation and dynamics of populations. Hence, the exploratory behaviour prior to actual dispersal may be crucial for potentially dispersing individuals. In mammals, females are traditionally seen as the more philopatric sex and dispersal as male‐biased behaviour, and so behavioural strategies related to the exploration of novel resources should be differentially expressed in males and females. In addition, due to sexual selection exploratory strategies may be expected to vary according to females’ reproductive phase. We employed a standard open‐field test as an approximation of the first phase of dispersal, using adult house mice representing two subspecies, M. m. musculus and M. m. domesticus. We tested the prediction that exploration of neutral area varies in females during different phases of the oestrus cycle and is different between both sexes and subspecies. We expected to find higher exploration in males, as the more dispersing sex and less pronounced subspecies‐specific differences in females than in males. We found no significant effect of the oestrous phase on any of the parameters of the exploratory behaviour measured. Sexual dimorphism was found only in latency to enter the arena in M. m. domesticus where females hesitated longer to enter a new area than males. Significant subspecies‐specific differences were found in three of four tested exploration parameters, so we conclude that females of both subspecies follow similar strategies to those displayed by males. Musculus mice show shorter latency to enter a new area, but once inside, domesticus mice explore the arena significantly longer, with less frequent retreats to a shelter. Our results thus highlight that the role of female dispersal in interdemic gene flow should not be neglected.

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Shaking the myth: Body mass, aggression, steroid hormones, and social dominance in wild house mouse

Cited by 27 publications

References 134 publications

Temporal dynamics of social hierarchy formation and maintenance in male mice

Temporal dynamics of social hierarchy formation and maintenance in male mice

Analysis of Copy Number Variation in the Abp Gene Regions of Two House Mouse Subspecies Suggests Divergence during the Gene Family Expansions

Female House Mice do not Differ in Their Exploratory Behaviour from Males

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