Shaken not stirred: A facile synthesis of 1,4-bis(furo[2,3-d]-pyrimidine-2,4(1H,3H)-dione-5-yl)benzenes by one-pot reaction of isocyanides, N,N′-dimethylbarbituric acid, and terephthaldialdehyde

A direct method for the N-tetraalkylation of azamacrocycles

“…Preferential outcomes when shaking rather than stirring have been reported for other transformations, for example in building heterocycles [44] and controlling dichromate oxidation of primary alcohols to aldehydes [45], although little explanation of these observations has been put forward. Shaking reaction media is also well established as a preferred method of sample agitation in biotechnology, where it allows additional parameters (e.g., oxygen supply and hydromechanical stress) to be optimised alongside mixing performance [46], and in nanotechnology, where shaking can be used to modulate aggregation so as to favour particular nanostructures [47–48].…”

Antitumor Activity of 6‐(cyclohexylamino)‐1,3‐dimethyl‐5(2‐pyridyl)furo[2,3‐d]pyrimidine‐2,4(1H,3H)‐dione and Its Ti(IV), Zn(II), Fe(III), and Pd(II) Complexes on K562 and Jurkat Cell Lines

“…Then, the resulting crystals were filtered and washed with diethyl ether (20 mL) to yield as light pink crystals (1.42 g, 80%). The dried product thus obtained showed a single spot on TLC and was pure enough for all analytical purposes [7] (see Figure 1). …”

“…However, many of the synthetic protocols reported so far prolonged reaction times, harsh reaction suffer from disadvantages, such as relying on multistep reactions, needing anhydrous conditions, low yields, use of metal-containing reagents, and special instruments or starting materials. Therefore, the development of new and efficient methods for the preparation of furo[2,3-d]pyrimidine derivatives is still strongly desirable [7]. …”

Design and effective synthesis of novel furo[2,3-d]pyrimidine derivatives containing ethylene ether spacers

“…Synthesis of furo-pyrimidines has received little attention and only few procedures have been reported in the literature [16][17][18][19][20][21][22][23][24][25][26], most of which rely on multi-step reactions with low yields. The existence of a lipophilic group in the furopyrimidine structure has been shown to improve the biological activity of these compounds [27,28].…”