SHA 102. Tissue plasminogen activator and plasminogen activator inhibitor-1 levels in patients with acute myocardial infarction and unstable angina

Habib, Syed Shahid; Kurdi, Mohammad Ibrahim; G, Abdel Galil Mohamad Abdel; Suriya, Mohammad Owais; Aseri, Zohair Al

doi:10.1016/j.jsha.2011.02.103

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“…Statistical analyses showed significant differentiating ability between UA and both SA and NSTEMI, but the significance of its differentiating ability was inferior to that of Lp(a). Similarly, multiple earlier studies detected significantly high tPA levels in MI patients than in UA patients but the significance is mostly at a level of <0.05 (20)(21)(22) . Moreover, adding tPA to conventional risk factors for chronic cardiac disease resulted in significant but small increases in discrimination and modest reclassification of risk (23) .…”

Section: Roc Curve Analysis Defined High Levels Ofmentioning

confidence: 58%

Estimation of serum levels of Lipoprotein(a) might help to resolve the dilemma of differentiation between Unstable Angina and Non-ST-elevation Myocardial Infarction

Elian

Mohammed

Marei

2023

Benha Medical Journal

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Objectives: Evaluation of the performance of estimated serum levels of lipoprotein(a) [Lp(a)] and tissue plasminogen activator (t-PA) in the discrimination between patients presenting by cardiac events. Patients & Methods: 314 patients presenting with a clinical picture suggestive of an acute cardiac event (ACE) underwent clinical and laboratory workup according to the 2017 ESC Guidelines for the management of acute myocardial infarction (AMI). Blood samples were obtained for ELISA estimation of serum Lp(a) and plasma t-PA levels. Results: Clinically, 247 patients had angina, 166 stable angina (SA), 81 unstable angina (UA), 67 patients had AMI, 44 had non-ST-elevation MI (NSTEMI) and 23 patients had STEMI. Serum levels of Lp(a)were significantly higher in total patients' samples especially UA and MI patients compared to control samples, but were lower in those with compared to patients' samples. Further, Lp(a) levels were significantly higher in MI than UA patients' samples. Estimated t-PA levels were significantly higher in patients' than control samples, but were significantly higher in MI than angina patients' samples. Statistical analyses defined high estimated levels of Lp(a), t-PA, total cholesterol, and obesity as the significant differentiating variables between SA and UA patients and defined high levels of LP(a), t-PA, and obesity, and age as the significant predictors for NSTEMI. Conclusion: Elevated serum levels of Lp(a) might differentiate between UA patients and SA and NSTEMI with high specificity.

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Section: Roc Curve Analysis Defined High Levels Ofmentioning

confidence: 58%