“…Currently, anti-inflammatory drugs (methotrexate and IL-1b inhibitorcanakinumab), which do not affect CRP or LDL cholesterol concentration, are being investigated. And if they proved to be effective, it would support the theory that atherosclerosis has an inflammatory Origin [20]. Thus a practical definition ohypertension is 'the level of BP at which the benefits of treatment towards the significance of the costs anhazards' [21] Oxidative stress because of excessive production of ROS outstripping antioxidant defense mechanism has been implicated in many pathophysiological conditions that affect the cardiovascular system, such as hypercholesterolemia, diabetes, and hypertension [22,23].…”