Abstract:• Dapagliflozin lowers blood pressure without clear effects on sodium excretion in people with T2D and preserved kidney function
• Dapagliflozin did not induce prolonged changes in plasma volume, extracellular volume, and intracellular volume
• Other nondiuretic-related effects cannot be ruled out in the CV protective effects conferred by SGLT2 inhibitors, including reductions in arterial stiffness, inhibition of the sympathetic nervous system, or restoration of endothelial function.
• Multiple intra-kidney… Show more
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