Sfrp1a and Sfrp5 function as positive regulators of Wnt and BMP signaling during early retinal development

Holly, Vanessa L.; Widen, Sonya A.; Famulski, Jakub K.; Waskiewicz, Andrew J.

doi:10.1016/j.ydbio.2014.01.012

Cited by 31 publications

(24 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A recent study has, however, reported increased expression of BMPs after inhibition of BMP signaling in zebrafish retinal development (Holly et al, 2014), without discussing a possible negative feedback mechanism. Neither did the authors examine whether retinal exposure to BMPs caused a decrease in BMP expression in the developing zebrafish retinas, which otherwise would have represented a second case of negative BMP auto-regulation.…”

Section: Discussionmentioning

confidence: 99%

Negative and positive auto-regulation of BMP expression in early eye development

Huang

Liu

Filas

et al. 2015

Developmental Biology

View full text Add to dashboard Cite

Previous results have shown that Bone Morphogenetic Protein (BMP) signaling is essential for lens specification and differentiation. How BMP signals are regulated in the prospective lens ectoderm is not well defined. To address this issue we have modulated BMP activity in a chicken embryo pre-lens ectoderm explant assay, and also studied transgenic mice, in which the type I BMP receptors, Bmpr1a and Acvr1, are deleted from the prospective lens ectoderm. Our results show that chicken embryo pre-lens ectoderm cells express BMPs and require BMP signaling for lens specification in vitro, and that in vivo inhibition of BMP signals in the mouse prospective lens ectoderm interrupts lens placode formation and prevents lens invagination. Furthermore, our results provide evidence that BMP expression is negatively auto-regulated in the lens-forming ectoderm, decreasing when the tissue is exposed to exogenous BMPs and increasing when BMP signaling is prevented. In addition, eyes lacking BMP receptors in the prospective lens placode develop coloboma in the adjacent wild type optic cup. In these eyes, Bmp7 expression increases in the ventral optic cup and the normal dorsal-ventral gradient of BMP signaling in the optic cup is disrupted. Pax2 becomes undetectable and expression of Sfrp2 increases in the ventral optic cup, suggesting that increased BMP signaling alter their expression, resulting in failure to close the optic fissure. In summary, our results suggest that negative and positive auto-regulation of BMP expression is important to regulate early eye development.

show abstract

Section: Discussionmentioning

confidence: 99%

Negative and positive auto-regulation of BMP expression in early eye development

Huang

Liu

Filas

et al. 2015

Developmental Biology

View full text Add to dashboard Cite

show abstract

“…The over-activation of Notch results in a pulse of proliferation followed by a compensatory downregulation of ligand, and eventually, differentiation, creating a bias toward early born neurons. Sfrps also facilitate interactions between Wnts with BMPs in the process of retinal dorsal-ventral patterning [45]. Sfrps, then, may be critical players in regulating the coordinated activities of multiple signaling pathways during retinogenesis, thereby influencing the context for associated Notch activity.…”

Section: Receptor Cleavage Regulationmentioning

confidence: 99%

The Regulation of Notch Signaling in Retinal Development and Regeneration

Mills

Goldman

2017

Curr Pathobiol Rep

View full text Add to dashboard Cite

Purpose of review Notch signaling is an important component of retinal progenitor cell maintenance and MG specification during development, and its manipulation may be critical for allowing MG to re-enter the cell cycle and regenerate neurons in adults. In mammals, MG respond to retinal injury by undergoing a gliotic response rather than a regenerative one. Understanding the complexities of Notch signaling may allow for strategies that enhance regeneration over gliosis. Recent findings Notch signaling is regulated at multiple levels, and is interdependent with various other signaling pathways in both the receptor and ligand expressing cells. The precise spatial and temporal patterning of Notch components is necessary for proper retinal development. Regenerative species undergo a dynamic regulation of Notch signaling in MG upon injury, whereas non-regenerative species fail to productively regulate Notch. Summary Notch signaling is malleable, such that the altered composition of growth and transcription factors in the developing and mature retinas result in different Notch mediated responses. Successful regeneration will require the manipulation of the retinal environment to foster a dynamic rather than static regulation of Notch signaling in concert with other reprogramming and differentiation factors.

show abstract

“…5) showed a reduced association of Bmp3 with Sfrp5 compared with that of Mest . This observation was somewhat surprising since Sfrp5 has been shown to modulate BMP signaling in the regulation of organogenesis [27] and retinal development [28] in zebrafish. However, although it is well recognized that significant cross-talk occurs between the Wnt and BMP/Smad signaling pathways [29, 30] and BMP and Wnt signaling are important mediators of adipogenesis [31], very little is known in regards to specific Sfrp5 -mediated effects on BMP signaling in mammals.…”

Section: Discussion/conclusionmentioning

confidence: 99%

Adipose tissue Mest and Sfrp5 are concomitant with variations of adiposity among inbred mouse strains fed a non-obesogenic diet

2016

View full text Add to dashboard Cite

The expression of a subset of genes including mesoderm specific transcript (Mest), secreted frizzled-related protein 5 (Sfrp5) and bone morphogenetic protein 3 (Bmp3) in adipose tissue biopsies of C57BL/6J mice before exposure to an obesogenic diet were shown to be predictive for the development of obesity in mice after feeding a high fat diet for 8 weeks. This observation led to the supposition that adipose tissue expression of this subset of genes within inbred strains of mice could be associated with their susceptibility in the development of adiposity when fed a low fat diet. The analyses of male mice from 5 inbred strains showed average bodyweights ranging from 25.82–36.58 grams at 16 weeks of age. Bodyweight was highest for AKR/J and adiposity correlated highly with bodyweight for all strains. Analyses of epididymal fat gene expression showed Mest, Sfrp5 and Bmp3 to be highly concomitant with adiposity across all strains of mice. Naked 1 (Nkd1), a gene previously shown to be associated with variations of adiposity in mice fed a high fat diet, but not predictive for the development of adiposity, showed no correlation with adiposity. In addition, the expression of Mest and Sfrp5 were tightly associated across the 5 mouse strains with the highest and lowest expression occurring in DBA/2J and C57BL/6J (B6) respectively suggesting a common mechanism for their regulation. Surprisingly, when independent cohorts for these 2 strains were fed high fat diet for 8 weeks, DBA/2J showed no further increase in Sfrp5 expression whereas expression levels for B6 mice were induced almost 20-fold. Analyses of (B6 × DBA2/J) F1 mice fed a low fat diet for 8 weeks showed intermediate levels of adiposity and gene expression for Sfrp5 and Mest suggesting a strong genetic basis for these differences.

show abstract

Sfrp1a and Sfrp5 function as positive regulators of Wnt and BMP signaling during early retinal development

Cited by 31 publications

References 45 publications

Negative and positive auto-regulation of BMP expression in early eye development

Negative and positive auto-regulation of BMP expression in early eye development

The Regulation of Notch Signaling in Retinal Development and Regeneration

Adipose tissue Mest and Sfrp5 are concomitant with variations of adiposity among inbred mouse strains fed a non-obesogenic diet

Contact Info

Product

Resources

About