SFRP1 upregulation causes hippocampal synaptic dysfunction and memory impairment
Guadalupe Pereyra,
María Inés Mateo,
María Jesús Martin-Bermejo
et al.
Abstract:Decreased dendritic complexity and impaired synaptic function are strongly linked to cognitive decline in Alzheimer's disease (AD), and precede the emergence of other neuropathological traits that establish a harmful cycle exacerbating synaptic dysfunction. SFRP1, a glial-derived protein regulating cell-cell communication, is abnormally elevated in the brain of AD patients and related mouse models already at early disease stages. Neutralization of SFRP1 activity in mice reduces the occurrence of protein aggreg… Show more
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