Sfrp1, Sfrp2, and Sfrp5 regulate the Wnt/β‐catenin and the planar cell polarity pathways during early trunk formation in mouse

Satoh, Wataru; Matsuyama, Makoto; Takemura, Hiromasa; Aizawa, Shin-Ichi; Shimono, Akihiko

doi:10.1002/dvg.20489

Cited by 24 publications

(39 citation statements)

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“…In light of our in vivo data and because sFRP2 can act as a modulator of the canonical Wnt pathway [15,17,[30][31][32], we felt compelled to investigate the action of sFRP2 in greater detail. Thus, we moved to an in vitro approach in the Cos7 and HCT116 cell lines using the TopFlash reporter vector.…”

Section: Sfrp2 Is Involved In Epithelial Cell Fate Determinationmentioning

confidence: 97%

The secreted Frizzled-Related Protein 2 modulates cell fate and the Wnt pathway in the murine intestinal epithelium

Skah

Nadjar

Sirakov

et al. 2015

Experimental Cell Research

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Section: Sfrp2 Is Involved In Epithelial Cell Fate Determinationmentioning

confidence: 97%

The secreted Frizzled-Related Protein 2 modulates cell fate and the Wnt pathway in the murine intestinal epithelium

Skah

Nadjar

Sirakov

et al. 2015

Experimental Cell Research

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“…Unfortunately, this led to chondrocyte apoptosis [48]. Other naturally occurring inhibitors that restrain Wnt-signaling in general are the soluble receptor like proteins sFRP1-5 [80], of which sFRP3 or FrzB is discussed above, Wnt Inhibitory Factor-1 (WIF-1) which binds Wnt and inhibit binding to Fzds [81] and Cerberus, which acts the same way as WIF [82]. It is thought that these mediators are not very specific in blocking certain Wnts but are relatively broad inhibitors of Wnt-signaling.…”

Section: Targeting Wnt Signaling; Tools and Approachesmentioning

confidence: 99%

To Seek Shelter from the Wnt in Osteoarthritis? Wnt-Signaling as a Target for Osteoarthritis Therapy

Blom¹,

Lent²,

Kraan³

et al. 2010

CDT

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Recent evidence from animal experiments and clinical samples points at a role for Wnt-signaling in osteoarthritis (OA) pathology. These pathways are key inducers and regulators of joint development, and are involved in formation of bone, cartilage and also synovium. Disregulation of members from this pathways have been described in OA. This makes the Wnt-family of proteins and signaling pathways an attractive target for therapy. Although knowledge is increasing rapidly it is still a challenge to decide on the best approach in targeting Wnt signaling. Activation of the canonical signaling pathway, which features intra-cellular accumulation of beta-catenin, is most often implicated in recent studies in OA pathology, in experimental OA and spondyloarthritis. However, direct targeting of beta-catenin is anticipated to be too hazardous, because of its importance for the maintenance of stability of articular chondrocyte phenotype and because of its proven role in carcinogenesis. A more attractive approach will be identifying the misexpression of specific Wnt-proteins or their inhibitors in various tissues that are important in OA, bone, cartilage and synovium, to point out targets for therapy. For example, recently it was shown that Wnt16 is strongly upregulated in cartilage after injury and in synovium in experimental OA, and the expression of this canonical Wnt may be responsible for OA-like changes. Alternatively, identifying more down stream Wnt signaling effector molecules, like WISP-1, for more specific therapy promises to be a safer and more efficient approach to find a treatment for this disease that heavily constrains millions of people each year.

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“…For instance, Frzb, which is expressed in the head organizer of Xenopus, inhibits Wnt8, a canonical Wnt ligand as a posteriorizing factor (Leyns et al 1997;Wang et al 1997). According to phenotypes of knockout mice, sFRP1, sFRP2, and sFRP5, which have some redundancy in their functions, are suggested to be involved in AP patterning of the vertebrae via the canonical Wnt pathway and morphogenetic cell movements via the Wnt PCP pathway (Satoh et al 2006(Satoh et al , 2008Warr et al 2009). Also Crescent and sFRP5 are suggested to regulate CEMs or morphogenetic cell movements as antagonists of Wnt ligands that stimulate the PCP pathway.…”

Section: Overview Of Wnt and Sfrpmentioning

confidence: 99%

Secreted Wnt “inhibitors” are not just inhibitors: Regulation of extracellular Wnt by secreted Frizzled-related proteins

Mii

Taira

2011

Development, Growth &Amp; Differentiation

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Gradient formation and signaling ranges of secreted proteins are crucial problems to understand how morphogens work for positional information and patterning in animal development. Yet, extracellular behaviors of secreted signaling molecules remain unexplored compared to their downstream pathways inside the cell. Recent advances in bioimaging make it possible to directly visualize morphogen molecules, and this simple strategy has, at least partly, succeeded in uncovering molecular behaviors of morphogens, such as Wnt (wingless-type MMTV integration site family member) and BMP (bone morphogenetic protein) as well as secreted Wnt binding proteins, sFRPs (secreted Frizzled-related proteins), in embryonic tissues. Here, we review the regulation of Wnt signaling by sFRPs, focusing on extracellular regulation of Wnt ligands in comparison with other morphogens. We also discuss evolutionary aspects with comprehensive syntenic and phylogenetic information about vertebrate sfrp genes. We newly annotated several sfrp genes including sfrp2-like 1 (sfrp2l1) in frogs and fishes and crescent in mammals.

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Sfrp1, Sfrp2, and Sfrp5 regulate the Wnt/β‐catenin and the planar cell polarity pathways during early trunk formation in mouse

Cited by 24 publications

References 0 publications

The secreted Frizzled-Related Protein 2 modulates cell fate and the Wnt pathway in the murine intestinal epithelium

The secreted Frizzled-Related Protein 2 modulates cell fate and the Wnt pathway in the murine intestinal epithelium

To Seek Shelter from the Wnt in Osteoarthritis? Wnt-Signaling as a Target for Osteoarthritis Therapy

Secreted Wnt “inhibitors” are not just inhibitors: Regulation of extracellular Wnt by secreted Frizzled-related proteins

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