sFlt-1, PlGF, sFlt-1/PlGF ratio and uterine artery Doppler for preeclampsia diagnostics

Tarasevičienė, Viktorija; Grybauskienė, Regina; Mačiulevičienė, Regina

doi:10.1016/j.medici.2016.11.008

Cited by 21 publications

(17 citation statements)

References 17 publications

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“…31 In addition, unlike the present study, other reports have shown that circulating sFlt-1 levels were significantly higher in early-onset preeclampsia than in late-onset preeclampsia. 32–34 In the present study, serum sFlt-1 levels in patients with severe preeclampsia were significantly higher than those in the mild preeclampsia group, which was comparable to a previous report. 35 Finally, to the best of the authors’ knowledge, the present study demonstrated for the first time that serum 25(OH)D was inversely correlated with sFlt-1 levels in female patients with preeclampsia.…”

Section: Discussionsupporting

confidence: 90%

Abnormal expression and clinical significance of 25-hydroxyvitamin D and sFlt-1 in patients with preeclampsia

Chen

Cui

et al. 2019

J Int Med Res

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Objective To determine the association between levels of serum 25-hydroxyvitamin D (25[OH]D) and soluble fms-like tyrosine kinase 1 (sFlt-1) in patients with preeclampsia. Methods Clinical and demographic data were collected from patients with preeclampsia and healthy pregnant controls. Serum 25(OH)D and sFlt-1 levels were evaluated by enzyme-linked immunosorbent assay and their correlations were determined using Spearman’s rank correlation coefficient. Associations between serum 25(OH)D and sFlt-1 levels and disease severity and clinical parameters were evaluated. Results Significantly lower serum 25(OH)D and higher sFlt-1 levels were observed in patients with preeclampsia ( n = 100) versus controls ( n = 100), and 25(OH)D was inversely correlated with sFlt-1 in patients with preeclampsia. Serum 25(OH)D levels were reduced, while sFlt-1 concentration was increased in patients with severe versus mild preeclampsia. Serum 25(OH)D levels were reduced in late-onset versus early-onset severe preeclampsia. Patients with preeclampsia who had lower serum 25(OH)D or elevated sFlt-1 levels showed significantly higher blood pressure indexes versus those with higher 25(OH)D or lower sFlt-1. Conclusions Low serum 25(OH)D and high sFlt-1 may be candidate biomarkers for preeclampsia diagnosis and prognosis.

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Section: Discussionsupporting

confidence: 90%

Abnormal expression and clinical significance of 25-hydroxyvitamin D and sFlt-1 in patients with preeclampsia

Chen

Cui

et al. 2019

J Int Med Res

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“…In another study, the highest sensitivity and specificity for preeclampsia had SFlt-1/PlGF and PlGF with the cut-off values of ≥35 (sensitivity of 95.8% and specificity of 96.2%, respectively) and ≤138.6 pg/mL (sensitivity of 95.8% and specificity of 93.7%, respectively). 12 Thus sFlt-1/PIGF has a high negative predictive value for ruling out preeclampsia in the patients who are at risk for the disease. This test is simple and easily reproducible.…”

Section: Discussionmentioning

confidence: 98%

The predictive value of sFlt-1/PIGF ratio in high risk patients for the development of preeclampsia

Sunil

Sharma

2019

Int J Reprod Contracept Obstet Gynecol

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Background: Hypertensive disorders of pregnancy constitute a major cause of maternal morbidity and mortality. Pre-eclampsia/eclampsia ranks second only to haemorrhage as a specific, direct cause of maternal mortality. A number of markers have been under study for the early detection of this disease. The study aims to evaluate the predictive value of sFlt-1/PlGF ratio for preeclampsia.Methods: This study was conducted in the Department of Gynaecology and Obstetrics of ASCOMS hospital, Jammu for a period of 6 months from Jan 2019 to June 2019. 50 antenatal patients attending the outpatient department with risk factors for developing preeclampsia were enrolled in the study. Their sFlT-1/PIGF ratio was determined at gestational age of 20 weeks to 37 weeks and its predictive value was evaluated.Results: In the present study, 8 patients developed preeclampsia subsequently. The mean sFlt-1/PIGF ratio values were significantly higher in the patients who developed preeclampsia (73.5) than who did not develop the disease (26.07). The positive predictive value at 1 week was 41.66% and negative predictive value was 100%. At 4 weeks, positive predictive value was 66.66% and negative predictive value was 100%.Conclusions: The present study suggests sFlt-1/PIGF ratio values are useful marker was a predictor of preeclampsia and values >38 were associated with preeclampsia. It is more useful in ruling out preeclampsia than ruling in the disease.

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“…[15] In another study, sensitivity/specificity rates of sFlt-1 and PGF to predict preeclampsia were 85/66% and 96/94%, but these rates increased up to 96/97% when sFlt-1 and PGF were proportioned (sFlt-1/PGF). [18] However, these biomarkers are very expensive and they still need confirmation. Simple, widespread and inexpensive laboratory findings are needed to establish the diagnosis of preeclampsia and to determine its severity.…”

Section: Discussionmentioning

confidence: 99%

The role of systemic inflammatory indexes in predicting preeclampsia and its severity

Bektaş¹,

Bektaş²,

Taşın³

2019

Perinatal J

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Sistemik inflamatuar indekslerin preeklampsiyi ve ciddiyetini öngörmedeki yeri Amaç: ‹mmün arac›l› inflamasyondaki anormal de¤ifliklikler preeklampsinin (PE) patogenezine katk›da bulunur. Bu çal›flmada amac›m›z sistemik inflamatuar indekslerini [nötrofil/lenfosit oran› (NLO), trombosit/lenfosit oran› (TLO), monosit/lenfosit oran› (MLO), trombosit /nötrofil oran› (TNO)] hastal›k göstergeleri olarak ve ayn› zamanda erken tan› imkân›, hastal›¤›n fliddetinin de-¤erlendirilmesi ve PE'nin prognozu için teorik bir temel olarak araflt›rmakt›r. Yöntem: Retrospektif olgu kontrollü olarak planlanan bu çal›flmada 573 gebenin klinik kay›tlar› tarand›. Yirmi sekiz hasta eklamptik nöbet geçirmesi, 50 hasta HELLP sendromu (hemoliz, trombositopeni ve yüksek karaci¤er transaminaz), 20 hasta süperempoze preeklampsi, 19 hasta kronik hipertansiyon, 25 hasta gestasyonel hipertansiyonu olmas› nedeniyle çal›flma d›fl›na al›nd›. Yüz doksan hasta PE, 119 hasta fliddetli PE ve 122 sa¤l›kl› tekil gebe kontrol grubuna al›narak 3 grup oluflturuldu. Tüm gruplar›n hemoglobin, trombosit say›s›, nötrofil, monosit, lenfosit de¤erleri ile birlikte sistemik inflamatuar yan›t belirteçleri olan NLO, TLO, MLO, TNO oranlar› kay›t alt›na al›nd› ve birbirleriyle karfl›laflt›-r›ld›. Bulgular: PE ve fliddetli PE gruplar› aras›nda anlaml› farkl›l›k tespit edilmezken, her iki PE grubu kontrol grubuyla ayr› ayr› karfl›-laflt›r›ld›¤›nda, trombosit, nötrofil, lenfosit ve monosit say›lar› ile NLO, TLO, MLO ve TNO de¤erleri istatistiksel olarak anlaml› farkl›l›k gösterdi. Kontrol ve PE gruplar› için NLO>3.497 olarak al›nd›¤›nda %51.5 sensitivite, %50.8 spesifisite, %71.9 pozitif prediktif de¤er, %71.4 negatif prediktif de¤er elde edilmektedir. Sonuç: Tam kan say›m› parametrelerinin sekonder analizleri sistemik inflamasyon ve ba¤›fl›kl›k durumunu etkin bir flekilde de¤erlendirmektedir. NLO ve TLO mutlak beyaz kan hücresi say›mla-r›na göre klinik de¤erlendirme, PE fliddetinin de¤erlendirilmesi ve PE'nin prognozunun de¤erlendirilmesi aç›s›ndan daha etkili göstergeler sunar. Ancak hâlihaz›rdaki bulgularla sistemik inflamatuar indeksler preeklampsi tan›s› koymada ve fliddetini öngörmede yeterli de¤ildirler.

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sFlt-1, PlGF, sFlt-1/PlGF ratio and uterine artery Doppler for preeclampsia diagnostics

Abstract: The sFlt-1/PlGF ratio and PlGF are superior to sFlt-1, UAPI and UARI for preeclampsia diagnosis. For early-onset preeclampsia diagnostics either sFlt-1 or PlGF is sufficient.

Cited by 21 publications

References 17 publications

Abnormal expression and clinical significance of 25-hydroxyvitamin D and sFlt-1 in patients with preeclampsia

Abnormal expression and clinical significance of 25-hydroxyvitamin D and sFlt-1 in patients with preeclampsia

The predictive value of sFlt-1/PIGF ratio in high risk patients for the development of preeclampsia

The role of systemic inflammatory indexes in predicting preeclampsia and its severity

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