Sézary Syndrome: A Model for Migration of T Lymphocytes to Skin

Ra, Miller; Cn, Coleman; Hd, Fawcett; Rt, Hoppe; Ir, McDougall

doi:10.1056/nejm198007103030206

Cited by 66 publications

(11 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These cells now are believed to arise in the spleen and lymph nodes, circulate in the blood, and migrate into the Subpopulations of T cells may normally migrate to cutaneous sites in response to antigens introduced into the skin. 20 The abnormal lymphocytes in this Scottish terrier closely resembled those described in human patients with SCzary syndrome. They were detected easily in this dog due to the profound leukemia.…”

Section: Discussionsupporting

confidence: 67%

Cutaneous Lymphosarcoma and Leukemia in a Dog Resembling Sézary Syndrome in Man

et al. 1984

View full text Add to dashboard Cite

Abstract. A dog with a lymphoproliferative disease resembling the Skzary syndrome variant of mycosis fungoides in man had large numbers of circulating morphologically abnormal lymphoid cells, multicentric cutaneous nodules and plaques, and extracutaneous involvement of lymph nodes and viscera. The presence of Pautrier's microabscesses, intracutaneous hyperchromatic cells, and leukemic cells with convoluted nuclei distinguished the disease from other types of cutaneous lymphoma.

show abstract

Section: Discussionsupporting

confidence: 67%

Cutaneous Lymphosarcoma and Leukemia in a Dog Resembling Sézary Syndrome in Man

et al. 1984

View full text Add to dashboard Cite

show abstract

“…Since E-selectin is highly expressed by cutaneous venules in the setting of chronic inflammation (more so than in other tissues in a similar setting [ll]), the CLA/Eselectin interaction offers one plausible mechanism for the selective cutaneous extravasation of CLA+ T cell subset. Finally, the observation that the malignant T cells of mycosis fungoides/Sezary syndrome selectively express CLA [lo, 301 and preferentially localize in skin [31] supports the occurrence of selective homing by the CLA+ subset as well.…”

Section: Discussionmentioning

confidence: 94%

Differential expression of lymphocyte homing receptors by human memory/effector T cells in pulmonary versus cutaneous immune effector sites

et al. 1994

View full text Add to dashboard Cite

The heterogeneous expression of lymphocyte homing receptors (HR) by the (CD45RA(low)/RO(high)) memory/effector T cell population in the human is thought to define subsets with tissue-selective recirculatory potential. To investigate further the localization characteristics of these T cells, we used multiparameter flow cytometry to quantitate T cell subsets defined by expression of the skin-selective HR called the cutaneous lymphocyte-associated antigen (CLA), the peripheral lymph node (PLN) HR L-selectin, the mucosal-associated HR alpha 4 beta 7-integrin, and the mucosal-associated adhesion molecule alpha e beta 7-integrin in either cutaneous or pulmonary immune effector sites and corresponding peripheral blood. Compared to peripheral blood, skin T cells were highly enriched for the CLA+/L-selectin+/alpha e beta 7-integrin- memory/effector subset, whereas lung memory/effector T cells were predominantly CLA-to low L-selectin-, and almost half were alpha e beta 7-integrin+. alpha 4 beta 7-integrin expressing memory/effector T cells were diminished in both skin and lung, suggesting that this HR is not a major participant in determining localization specificity in either of these sites. The characteristic pulmonary T cell HR phenotype did not significantly differ between the normal subjects and those with pulmonary inflammatory disease, and did not correlate with markers of T cell activation. Induction of a rapid up-regulation of pulmonary inflammation via intrabronchial allergen challenge in asthmatic patients tended to decrease localization specificity, resulting in a more general importation of memory/effector subsets. Taken together, these results suggest that tissue microenvironments play a major role in determining the character of local T cell infiltrates via their ability to import and retain memory/effector subsets selectively or, more generally, depending on the intensity of local inflammatory stimuli.

show abstract

“…However, in mycosis fungoides the skin eruption is scaly and progresses through a plaque stage leading to skin tumors [14], while in the Sezary syndrome a generalized exfoliative erythroderma is characteristic [14,15]. In our patient, the skin presentation was, from the outset, in the form of purplish nodular tu mors.…”

Section: Commentsmentioning

confidence: 84%

Lymphoma of Cytotoxic/Suppressor T Cell Phenotype (T<sub>8</sub>) following Angioimmunoblastic Lymphadenopathy

Rubinstein¹,

Dauber

1983

Oncology

View full text Add to dashboard Cite

A patient with angioimmunoblastic lymphadenopathy was treated with chemotherapy to complete remission for 13 years. A single relapse, self-limited, occurred followed 2 years later by the appearance of a disseminated non-Hodgkin’s lymphoma with prominent cutaneous lesions and hypogammaglobulinemia. Cells from the peripheral blood and an affected lymph node were characterized by immunologic studies as deriving from the T₈ subset of lymphocytes, suggesting a functional relationship between these suppressor cells and the patient’s clinical manifestations.

show abstract

Sézary Syndrome: A Model for Migration of T Lymphocytes to Skin

Cited by 66 publications

References 10 publications

Cutaneous Lymphosarcoma and Leukemia in a Dog Resembling Sézary Syndrome in Man

Cutaneous Lymphosarcoma and Leukemia in a Dog Resembling Sézary Syndrome in Man

Differential expression of lymphocyte homing receptors by human memory/effector T cells in pulmonary versus cutaneous immune effector sites

Lymphoma of Cytotoxic/Suppressor T Cell Phenotype (T<sub>8</sub>) following Angioimmunoblastic Lymphadenopathy

Contact Info

Product

Resources

About