Sexually transmitted infections in people with multidrug-resistant HIV

Clemente, Tommaso; Lolatto, Riccardo; Papaioannu Borjesson, Rebecka; Fabbiani, Massimiliano; Manzillo, Elio; Fronti, Elisa; Di Giambenedetto, Simona; Gagliardini, Roberta; Rusconi, Stefano; Santoro, Maria M.; Castagna, Antonella; Spagnuolo, Vincenzo

doi:10.1097/qad.0000000000003690

Cited by 1 publication

(1 citation statement)

References 9 publications

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“…For example, we recently used retrospective data from the registry to evaluate the occurrence of STIs in 178 4DR-PLWH and found a non-negligible incidence of bacterial infections (1.3/100 person-years-of-follow-up in men, 0 in women), together with the occurrence of viral infections (first diagnosis of genital herpes simplex virus in 3.8% of men and 2.2% of women; first diagnosis of human papillomavirus in 8.3% of men and 6.5% of women). 23 Although all bacterial STIs were diagnosed when HIV-1 RNA was <200 copies/mL, these findings highlight the need for strict HIV viremia monitoring, accurate ART adherence and STI prevention counselling in the population with HIV 4DR.…”

Section: Cohort Descriptionmentioning

confidence: 90%

Cohort profile: PRESTIGIO, an Italian prospective registry-based cohort of people with HIV-1 resistant to reverse transcriptase, protease and integrase inhibitors

Clemente,

Galli,

Lolatto

et al. 2024

BMJ Open

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PurposeThe PRESTIGIO Registry was established in 2017 to collect clinical, virological and immunological monitoring data from people living with HIV (PLWH) with documented four-class drug resistance (4DR). Key research purposes include the evaluation of residual susceptibility to specific antiretrovirals and the validation of treatment and monitoring strategies in this population.ParticipantsThe PRESTIGIO Registry collects annual plasma and peripheral blood mononuclear cell samples and demographic, clinical, virological, treatment and laboratory data from PLWH followed at 39 Italian clinical centres and characterised by intermediate-to-high genotypic resistance to ≥1 nucleoside reverse transcriptase inhibitors, ≥1 non-nucleoside reverse transcriptase inhibitors, ≥1 protease inhibitors, plus either intermediate-to-high genotypic resistance to ≥1 integrase strand transfer inhibitors (INSTIs) or history of virological failure to an INSTI-containing regimen. To date, 229 people have been recorded in the cohort. Most of the data are collected from the date of the first evidence of 4DR (baseline), with some prebaseline information obtained retrospectively. Samples are collected from the date of enrollment in the registry.Findings to dateThe open-ended cohort has been used to assess (1) prognosis in terms of survival or development of AIDS-related or non-AIDS-related clinical events; (2) long-term efficacy and safety of different antiretroviral regimens and (3) virological and immunological factors predictive of clinical outcome and treatment efficacy, especially through analysis of plasma and cell samples.Future plansThe registry can provide new knowledge on how to implement an integrated approach to study PLWH with documented resistance to the four main antiretroviral classes, a population with a limited number of individuals characterised by a high degree of frailty and complexity in therapeutic management. Given the scheduled annual updates of PLWH data, the researchers who collaborate in the registry can send study proposals at any time to the steering committee of the registry, which evaluates every 3 months whether the research studies can be conducted on data and biosamples from the registry and whether they are aimed at a better understanding of a specific health condition, the emergence of comorbidities or the effect of potential treatments or experimental drugs that may have an impact on disease progression and quality of life. Finally, the research studies should aim to be inclusive, innovative and in touch with the communities and society as a whole.Trial registration numberNCT04098315.

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Section: Cohort Descriptionmentioning

confidence: 90%