Sexually transmitted infections: impact on male fertility

Fr, Ochsendorf

doi:10.1111/j.1439-0272.2007.00825.x

Cited by 168 publications

(120 citation statements)

References 28 publications

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“…Behavioral disinhibition and related cognitive impairments from heavy drinking or drug use increase risk for unprotected sexual intercourse and, consequently, sexually transmitted infections (Ericksen and Trocki, 1994). If untreated, sexually transmitted infections, such as chlamydia, gonorrhea, syphilis, and HIV/AIDS, are a leading cause of reproductive problems, including both female and male infertility (Grodstein et al, 1993;Ochsendorf, 2008;Pellati et al, 2008;Wallace et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Smoking and Illicit Drug Use Associations With Early Versus Delayed Reproduction: Findings in a Young Adult Cohort of Australian Twins

Waldron

Heath²,

Lynskey³

et al. 2009

J. Stud. Alcohol Drugs

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ABSTRACT. Objective: This article examines relationships between reproductive onset and lifetime history of smoking, regular smoking, and nicotine dependence, and cannabis and other illicit drug use. Method: Data were drawn from a young adult cohort of 3,386 female and 2,751 male Australian twins born between 1964 and 1971. Survival analyses were conducted using Cox proportional hazards regression models predicting age at fi rst childbirth from history of substance use or disorder separately by substance class. Other substance use or disorder, including alcohol dependence, as well as sociodemographic characteristics, history of psychopathology, and family and childhood risks, were included as control variables in adjusted models. Results: Regular smoking and nicotine dependence were associated with earlier reproduction, with pronounced effects for women. For women, use of cannabis was associated with early reproduction before age 20, and with delayed reproduction among women who have not reproduced by age 20 or 25. Adjustment for control variables only partially explained these associations. Conclusions: Consistent with research linking adolescent use with sexual risk taking predictive of early childbearing, regular smokers and nicotine-dependent individuals show earlier reproductive onset. In contrast, delays in childbearing associated with use of cannabis are consistent with impairments in reproductive ability and/or opportunities for reproduction. Continued research on risks both upstream and downstream of substance-use initiation and onset of substance-use disorder is needed for causal mechanisms to be fully understood. (J. Stud. Alcohol

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Section: Discussionmentioning

confidence: 99%

Smoking and Illicit Drug Use Associations With Early Versus Delayed Reproduction: Findings in a Young Adult Cohort of Australian Twins

Waldron

Heath²,

Lynskey³

et al. 2009

J. Stud. Alcohol Drugs

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“…Viral infections in the epididymis may perturb fertility and spread sexually transmitted pathogens (4,(32)(33)(34). The mechanisms underlying the innate antiviral responses in the epididymis merit clarification.…”

Section: Discussionmentioning

confidence: 99%

“…Different virus types (e.g., RNA and DNA viruses) that can infect the epididymis are associated with male infertility (3). Moreover, viral infections of the epididymis may sexually spread pathogens (4). Understanding the mechanisms underlying epididymal innate antiviral responses would aid in the development of preventive and therapeutic strategies against viral infections of the epididymis.…”

mentioning

confidence: 99%

Pattern Recognition Receptor–Initiated Innate Antiviral Responses in Mouse Epididymal Epithelial Cells

Zhu

Zhao

Liu

et al. 2015

The Journal of Immunology

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Viral infections of the epididymis may impair male fertility and spread sexually transmitted pathogens. The innate antiviral immune responses in the epididymis have yet to be intensively investigated. This study found that mouse epididymal epithelial cells (EECs) constitutively express several viral sensors, including TLR3, retinoic acid–inducible gene I, and DNA-dependent activator of IFN regulatory factors. Other DNA sensors, including p204 and cGMP-AMP synthase, can be induced by transfection of synthetic HSV genomic DNA (HSV60). TLR3 and retinoic acid–inducible gene I in EECs can be activated by their common agonist, polyinosinic-polycytidylic acid [poly(I:C)]. The signaling pathway of DNA sensors can be initiated by HSV60. Both poly(I:C) and HSV60 induced the expression of type 1 IFNs and various antiviral proteins, including IFN-stimulated gene 15, 2′,5′-oligoadenylate synthetase, and myxovirus resistance 1. Poly(I:C), but not HSV60, also dramatically induced the expression of major proinflammatory cytokines, including TNF-α and MCP-1, in EECs. In vivo assay confirmed that the local injection of poly(I:C) or HSV60 induced the innate antiviral responses in EECs. This study provided novel insights into the mechanisms underlying the innate antiviral responses in the mouse epididymis.

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“…Bacteria eliciting epididymoorchitis are either sexually transmitted or originate from urinary tract infections (Purvis & Christiansen, 1993;Weidner et al, 1999;Anders & Patole, 2005;Ludwig, 2008). Among sexually active men younger than 35 years with a medical history of urethral discharge, the most prevalent pathogens related to epididymo-orchitis are Chlamydia trachomatis and Neisseria gonorrhoeae (Weidner et al, 1999;Ludwig, 2008;Ochsendorf, 2008).…”

Section: Relevant Pathogens Causing Testicular Dysfunctionmentioning

confidence: 99%