Sexually Transmitted Diseases Among US Adolescents and Young Adults

Sieving, Renee E.; O’Brien, Jennifer; Saftner, Melissa A.; Argo, Taylor A.

doi:10.1016/j.cnur.2019.02.002

Cited by 28 publications

(34 citation statements)

References 29 publications

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“…STIs are represented mainly by eight infections, four of which can be cured, namely, syphilis, gonorrhea, chlamydia, and trichomoniasis. The other four are caused by viruses (hepatitis B virus, herpes simplex virus, HIV and human papillomavirus) and are incurable, although there are treatments capable of attenuating, controlling, or modifying the symptoms or the disease (6,8).…”

Section: Resultsmentioning

confidence: 99%

Characterization of sexually transmitted infections, their pharmacological treatment, and recurrence in a Colombian population

et al. 2021

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Introduction: Sexually transmitted infections are a public health problem worldwide. Their inadequate antimicrobial management has been associated with a higher risk of recurrence. Objective: To characterize the main sexually transmitted infections, the adherence to clinical practice guidelines in Colombia, and the factors associated with recurrence. Materials and methods: This observational study identified the main sexually transmitted infections, sociodemographic variables, and pharmacological management in a patient cohort from a population database of 6.5 million people affiliated with the Colombian Health System. A multivariate analysis was performed to identify variables associated with recurrence. Results: A total of 3158 patients were identified, with a mean age of 41.8 ± 14.5 years, and 63.1% were men. There were 4030 episodes of sexually transmitted infections, predominantly urethral syndrome (27.5%). Only 13.6% of patients with urethral syndrome, ulcerative syndrome, or genital warts were managed in compliance with clinical practice guidelines. A total of 20.6% of patients were dispensed condoms. A total of 16.7% of all patients had recurrences, and being male (OR:1.32; 95%CI:1.08-1.63), being <30 years old (OR:1.72; 95%CI:1.40-2.13), being treated in municipalities other than capital cities (OR:1.43; 95%CI:1.06-1.94), and having received inadequate treatment for the first episode (OR:1.93; 95%CI:1.52-2.39) were associated with recurrence. Conclusions: The majority of patients with sexually transmitted infections were not treated in compliance with clinical practice guidelines, and those who did not have adequate management had a higher risk of recurrence.

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Section: Resultsmentioning

confidence: 99%

Characterization of sexually transmitted infections, their pharmacological treatment, and recurrence in a Colombian population

et al. 2021

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“…It is likely that older individuals are more aware of the importance of reproductive health screening and treatment. Youth and young adults, especially under the age of 25 years, are considered a high risk population for STIs [31]. Health education and screening efforts should be focused on this population who are sexually active including facilitation of human papillomavirus vaccine uptake [32].…”

Section: Discussionmentioning

confidence: 99%

“…It may be the case that females bear the stigma associated with STIs, while males seek treatment for such infections. Approximately 10-15% of untreated cases among females may lead to severe health outcomes such as pelvic inflammatory disease [31]. Thus, understanding factors that can motivate or facilitate females to seek STI screening and treatment is critical.…”

Section: Discussionmentioning

confidence: 99%

Proximity to Screening Site, Rurality, and Neighborhood Disadvantage: Treatment Status among Individuals with Sexually Transmitted Infections in Yakima County, Washington

Amiri

Pham

Amram

et al. 2020

IJERPH

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Background: Early sexually transmitted infections (STIs) diagnosis facilitates prompt treatment initiation and contributes to reduced transmission. This study examined the extent to which contextual characteristics such as proximity to screening site, rurality, and neighborhood disadvantage along with demographic variables, may influence treatment seeking behavior among individuals with STIs (i.e., chlamydia, gonorrhea, and syphilis). Methods: Data on 16,075 diagnosed cases of STIs between 2007 and 2018 in Yakima County were obtained from the Washington State Department of Health Database Surveillance System. Multilevel models were applied to explore the associations between contextual and demographic characteristics and two outcomes: (a) not receiving treatment and (b) the number of days to receiving treatment. Results: Contextual risk factors for not receiving treatment or having increased number of days to treatment were living ≥10 miles from the screening site and living in micropolitan, small towns, or rural areas. Older age was a protective factor and being female was a risk for both outcomes. Conclusions: Healthcare providers and facilities should be made aware of demographic and contextual characteristics that can impact treatment seeking behavior among individuals with STIs, especially among youth, females, and rural residents.

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“…Recently, Mycoplasma genitalium has been increasingly recognized as a sexually transmitted pathogen, but there is no defined public health response to this relatively newly identified STI so far (1). Moreover, besides being one of the causative agents responsible for non-gonococcal urethritis (NGU), M. genitalium is also related to diseases such as cervicitis, tubal infertility, pelvic inflammation and endometritis, which may catalyze the pathological effects of serious syndromes and permanent chronic conditions, such as infertility, chronic pelvic pain and ectopic pregnancy (2,3). M. genitalium can cause opportunistic infections in AIDS patients by promoting the replication of the human immunodeficiency virus (HIV), thereby accelerate the death of patients (4,5) and hence is also known as AIDS-related Mycoplasma.…”

Section: Introductionmentioning

confidence: 99%

Mycoplasma genitalium Protein of Adhesion Induces Inflammatory Cytokines via Cyclophilin A-CD147 Activating the ERK-NF-κB Pathway in Human Urothelial Cells

et al. 2020

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Mycoplasma genitalium protein of adhesion (MgPa) plays an important role in the process of adhesion and invasion of host cells by M. genitalium, and is thus significant for its pathogenic mechanisms in host cells. Our previous study has demonstrated that cyclophilin A (CypA) is the receptor for MgPa in human urothelial cells (SV-HUC-1) and can, therefore, mediate the adherence and invasion of M. genitalium into host cells by interacting with MgPa. However, the specific pathogenesis of M. genitalium to host cells and the possible pathogenic mechanism involved in the interaction of MgPa and CypA have never been clarified. The study aimed to elucidate the mechanism involved in the pathogenicity of MgPa. Recombinant MgPa (rMgPa) induced extracellular CypA (eCypA) was detected in SV-HUC-1 cells by ELISA, and the interaction between CypA and CD147 was validated using co-localization and co-immunoprecipitation assay. In addition, both extracellular signal-regulated kinases (ERK) phosphorylation and NF-κB activation evoked by rMgPa-induced eCypA were also demonstrated. The findings of this study verified that rMgPa could induce the secretion of eCypA in SV-HUC-1 cells and thus promote the protein and mRNA expression of IL-1β, IL-6, TNF-α and MMP-9 via CypA-CD147 interaction and thus activating ERK-NF-κB pathway, which is beneficial to elucidate the pathogenesis and possible pathogenic mechanism of M. genitalium to host cells.

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Sexually Transmitted Diseases Among US Adolescents and Young Adults

Cited by 28 publications

References 29 publications

Characterization of sexually transmitted infections, their pharmacological treatment, and recurrence in a Colombian population

Characterization of sexually transmitted infections, their pharmacological treatment, and recurrence in a Colombian population

Proximity to Screening Site, Rurality, and Neighborhood Disadvantage: Treatment Status among Individuals with Sexually Transmitted Infections in Yakima County, Washington

Mycoplasma genitalium Protein of Adhesion Induces Inflammatory Cytokines via Cyclophilin A-CD147 Activating the ERK-NF-κB Pathway in Human Urothelial Cells

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