Sexually dimorphic expression of a teleost homologue of Müllerian inhibiting substance during gonadal sex differentiation in Japanese flounder, Paralichthys olivaceus

Yoshinaga, N.; Shiraishi, Eri; Yamamoto, Takashi; Iguchi, Taisen; Abe, Shinichi; Kitano, Takeshi

doi:10.1016/j.bbrc.2004.07.162

Cited by 122 publications

(77 citation statements)

References 16 publications

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“…For instance, in this case, amh was expressed predominantly in the somatic cells of the medullar area of the gonads of putative males, which is devoid of germ cells and where eventually the efferent ducts are formed. This pattern of distribution agrees with reports for Japanese flounder (Yoshinaga et al, 2004), rainbow trout (Baron et al, 2005), zebrafish (Rodríguez-Mari et al, 2005), and Japanese eel (Miura et al, 2002) and suggests that amh plays a similar role, probably related to the formation of the efferent ducts, in these four teleost species.…”

Section: Discussionsupporting

confidence: 90%

“…On the other hand, most teleost fish do not have Mü llerian ducts but they do possess an amh homologue that usually shows a sexually dimorphic expression profiles during gonadal sex differentiation and/or adulthood. For example in Japanese flounder (Yoshinaga et al 2004), zebrafish (Rodrí-guez-Mari et al, 2005;Wang and Orban, 2007), and rainbow trout (Baron et al, 2005), amh is first expressed at low levels in the undifferentiated gonads of both sexes and then at higher levels in the male gonads compared with those of females during the process of gonadal sex differentiation. A sex-related difference in gene expression during this process was also observed in the amh type II receptor, but not in amh itself in the Japanese medaka (Kluver et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

“…In two species with TSD; the reptile, Alligator mississippiensis (Western et al, 1999) and the teleost, Paralichthys olivaceus (Yoshinaga et al, 2004), increased amh expression was found at male producing temperatures. Our experimental model, the pejerrey Odontesthes bonariensis, is a gonochoristic fish with strong TSD.…”

Section: Introductionmentioning

confidence: 99%

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Expression profile and estrogenic regulation of anti‐Müllerian hormone during gonadal development in pejerrey Odontesthes bonariensis, a teleost fish with strong temperature‐dependent sex determination

Fernandino

Hattori

Kimura

et al. 2008

Developmental Dynamics

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Pejerrey is a teleost fish presenting a strong temperature-dependent sex determination. This study was conducted to clone pejerrey amh cDNA, analyze its expression profile during thermal and endocrine manipulation of gonadal differentiation, and compare its expression with that of gonadal aromatase (cyp19a1). Amh displayed higher expression at masculinizing than at feminizing temperatures during the gonadal differentiation period. Its expression at an intermediate temperature (females 1:1 males), was high in half of the larvae and low in the other half. Cyp19a1 showed a reciprocal expression pattern to that of amh both individually-and temperature-wise. Increased cyp19a1 and amh expression was observed before morphological gonadal differentiation. Amh expression in larvae feminized by administration of estradiol or masculinized by the administration of an aromatase inhibitor was down-and up-regulated, respectively. These results show that amh plays a critical role in testicular differentiation and it is apparently modulated by estrogens in this species. Developmental Dynamics 237:3192-3199, 2008.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

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Expression profile and estrogenic regulation of anti‐Müllerian hormone during gonadal development in pejerrey Odontesthes bonariensis, a teleost fish with strong temperature‐dependent sex determination

Fernandino

Hattori

Kimura

et al. 2008

Developmental Dynamics

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“…Immature Sertoli cells around the spermatogonia are the source for Amh in fish testis (Miura et al 2002, Yoshinaga et al 2004, Vizziano et al 2008. One effect of 11-KT (or testosterone in mammals) in a complex regulative network is the down-regulation of Amh (Al-Attar et al 1997, Miura et al 2002, Rey et al 2003.…”

Section: Role Of 11-kt In Stable D-malesmentioning

confidence: 99%

The social status of the male Nile tilapia (Oreochromis niloticus) influences testis structure and gene expression

Pfennig¹,

Kurth²,

Meißner³

et al. 2012

Reproduction

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Dominant and territorial behaviour are known social phenomena in cichlids and social stress influences reproduction and growth. The gonadotropic hormones trigger spermatogenesis and subordinate males have typically lower levels of gonadotropins than dominant males. In this study, we compared testis morphology and gene expression of dominant and subordinate Nile tilapia males (d-and s-males) in socially stable communities. The d-males had the highest gonadosomatic index but they were not the largest animals in the majority of studied cases. Long-term d-males showed large groups of Leydig cells and hyperplasia of the tunica albuginea due to numerous cytochrome-P450-11b-hydroxylase (Cyp11b) expressing myoid cells. Increased Cyp11b expression in d-males was reflected by elevated 11-ketotestosterone plasma values. However, immunofluorescence microscopy and expression analysis of selected genes revealed that most s-males conserved their capability for spermatogenesis and are, therefore, ready for reproduction when the social environment changes. Moreover, in s-males gene expression analysis by quantitative RT-PCR showed increased transcript levels for germ line-specific genes (vasa, sox2 and dmc1) and Sertoli-specific genes (amh, amhrII and dmrt1) whereas gene expression of key factors for steroid production (sf1 and cyp11b) were reduced. The Nile tilapia is a promising model to study social cues and gonadotropic signals on testis development in vertebrates.

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“…Upregulation of amh expression has been observed during TIM in Japanese flounder (Yoshinaga et al 2004, Kitano et al 2007, Yamaguchi & Kitano 2012, Southern flounder (Paralichthys lethostigma; Mankiewicz et al 2013), Nile tilapia (Oreochromis niloticus; Poonlaphdecha et al 2013) and pejerrey (Fernandino et al 2008), and likewise during protogynous sex change in ricefield eel (Monopterus albus) (Hu et al 2015). Acting as a transcription factor, the Amh protein is also known to directly inhibit the cyp19a1a expression in mammals, and an inverse association between amh and cyp19a1a expression is reported in numerous fishes, including Japanese flounder (Kitano et al 2007), pejerrey (Fernandino et al 2008), rainbow trout (Vizziano et al 2008), southern flounder (Mankiewicz et al 2013) and zebrafish (Danio rerio; Rodríguez-Marí et al 2005, Wang & Orban 2007.…”

Section: Upregulation Of Amh Promoting Gonadal Apoptosis and Malenessmentioning

confidence: 99%

Stress and sex: does cortisol mediate sex change in fish?

Goikoetxea¹,

Todd²,

Gemmell³

2017

Reproduction

102

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Cortisol is the main glucocorticoid (GC) in fish and the hormone most directly associated with stress. Recent research suggests that this hormone may act as a key factor linking social environmental stimuli and the onset of sex change by initiating a shift in steroidogenesis from estrogens to androgens. For many teleost fish, sex change occurs as a usual part of the life cycle. Changing sex is known to enhance the lifetime reproductive success of these fish and the modifications involved (behavioral, gonadal and morphological) are well studied. However, the exact mechanism behind the transduction of the environmental signals into the molecular cascade that underlies this singular process remains largely unknown. We here synthesize current knowledge regarding the role of cortisol in teleost sex change with a focus on two well-described transformations: temperature-induced masculinization and socially regulated sex change. Three non-mutually exclusive pathways are considered when describing the potential role of cortisol in mediating teleost sex change: cross-talk between GC and androgen pathways, inhibition of aromatase expression and upregulation of amh (the gene encoding anti-Müllerian hormone). We anticipate that understanding the role of cortisol in the initial stages of sex change will further improve our understanding of sex determination and differentiation across vertebrates, and may lead to new tools to control fish sex ratios in aquaculture.Reproduction (2017) 154 R149-R160

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Sexually dimorphic expression of a teleost homologue of Müllerian inhibiting substance during gonadal sex differentiation in Japanese flounder, Paralichthys olivaceus

Cited by 122 publications

References 16 publications

Expression profile and estrogenic regulation of anti‐Müllerian hormone during gonadal development in pejerrey Odontesthes bonariensis, a teleost fish with strong temperature‐dependent sex determination

Expression profile and estrogenic regulation of anti‐Müllerian hormone during gonadal development in pejerrey Odontesthes bonariensis, a teleost fish with strong temperature‐dependent sex determination

The social status of the male Nile tilapia (Oreochromis niloticus) influences testis structure and gene expression

Stress and sex: does cortisol mediate sex change in fish?

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