Sexually dimorphic effects of monoacylglycerol lipase inhibitor MJN110 on stress‐related behaviour and drinking in Marchigian Sardinian alcohol‐preferring rats
Valentina Vozella,
Bryan Cruz,
Hannah C. Feldman
et al.
Abstract:Background and PurposeStress‐related disorders are often intertwined with alcohol use disorder (AUD). The endocannabinoid (eCB) system, which comprises the lipid mediators anandamide (AEA) and 2‐arachidonoylglycerol (2‐AG), plays an important homeostatic role in the regulation of stress circuits and has emerged as a therapeutic target to treat stress disorders and AUD. Extensive research has elucidated the role of AEA, but less is known about 2‐AG‐mediated signaling.Experimental ApproachWe pharmacologically en… Show more
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