2013
DOI: 10.2337/db12-0561
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Sexually Dimorphic Effects of Maternal Nutrient Reduction on Expression of Genes Regulating Cortisol Metabolism in Fetal Baboon Adipose and Liver Tissues

Abstract: Maternal nutrient reduction (MNR) during fetal development may predispose offspring to chronic disease later in life. Increased regeneration of active glucocorticoids by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) in metabolic tissues is fundamental to the developmental programming of metabolic syndrome, but underlying mechanisms are unknown. Hexose-6-phosphate dehydrogenase (H6PD) generates NADPH, the cofactor for 11β-HSD1 reductase activity. CCAAT/enhancer binding proteins (C/EBPs) and the glucocortic… Show more

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Cited by 51 publications
(36 citation statements)
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References 55 publications
(71 reference statements)
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“…Importantly, life-span effects are influenced by developmental programming by challenges such as altered F 1 nutrition during their development. The mechanisms are likely multiple and include both programmed changes within the hypothalamo-pituitary adrenal axis (Braun et al 2013;Zambrano et al 2014) and altered peripheral production of glucocorticoids in adipose tissue that are influenced by maternal nutrition (Guo et al 2013). The influence of developmental programming is clearly shown by the difference in the corticosterone concentrations in the F 1 from control and obese mothers.…”
Section: Discussionmentioning
confidence: 99%
“…Importantly, life-span effects are influenced by developmental programming by challenges such as altered F 1 nutrition during their development. The mechanisms are likely multiple and include both programmed changes within the hypothalamo-pituitary adrenal axis (Braun et al 2013;Zambrano et al 2014) and altered peripheral production of glucocorticoids in adipose tissue that are influenced by maternal nutrition (Guo et al 2013). The influence of developmental programming is clearly shown by the difference in the corticosterone concentrations in the F 1 from control and obese mothers.…”
Section: Discussionmentioning
confidence: 99%
“…type 2 (11β-HSD2) contents) and fat expansion has been observed in offspring from malnourished dams (Gnanalingham et al 2005, Lukaszewski et al 2011, Guo et al 2013. Third, increased expression of GR and 11β-HSD1 in visceral adipose tissue has been associated with the development of obesity in rats overfed during lactation (Boullu-Ciocca et al 2008).…”
Section: Figurementioning
confidence: 97%
“…Nutritional manipulations in the perinatal period can predispose to obesity and imprint adipogenesis in offspring in a Review E1202 PERINATAL NUTRITION AND ADIPOSE TISSUE PROGRAMMING sex-dependent manner (7,42,43,50,61,100). The reasons for these sex-specific programming effects remain unknown but could reflect direct interactions between nutritional signals and sex hormones in tissues of the developing fetus (1).…”
Section: Sexual Dimorphism and Transgenerational Programmingmentioning
confidence: 99%