Sexually dimorphic acquisition of a conditioned taste aversion in rats: Effects of gonadectomy, testosterone replacement and water deprivation☆

Chambers, Kathleen C.; Sengstake, Cord B.; Yoder, Rebecca L.; Thornton, Janice E.

doi:10.1016/0031-9384(81)90303-6

Cited by 45 publications

(37 citation statements)

References 9 publications

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“…Alternatively, the results from the present study could be specific to MFinduced CTA or due to differences in testing parameters [e.g., one-bottle vs. two-bottle tests (50,66,67) or sucrose vs. saccharin (9,57).] It may be relevant that we matched saccharin intakes between male and female groups by excluding rats with the highest and lowest intakes during conditioning.…”

Section: Discussionmentioning

confidence: 92%

“…A specific role for sex steroids in the modulation of extinction rates has been demonstrated in a few studies, but no study has examined cyclic variation across the estrous cycle. Testosterone has been shown to slow extinction, whereas estradiol has been shown to accelerate extinction of CTA in gonadectomized male and female rats (8,9,17,57,66,67). Thus, in LiCl-induced CTA, sex steroids have an activational effect on extinction rate, whereas in MF-induced CTA there is an organizational sex difference.…”

Section: Discussionmentioning

confidence: 93%

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Sex and estrous cycle differences in the behavioral effects of high-strength static magnetic fields: role of ovarian steroids

Cason¹,

DenBleyker²,

Ferrence³

et al. 2006

American Journal of Physiology-Regulatory, Integrative and Comp

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Advances in magnetic resonance imaging are driving the development of higher-resolution machines equipped with high-strength static magnetic fields (MFs). The behavioral effects of high-strength MFs are largely uncharacterized, although in male rats, exposure to 7 T or above induces locomotor circling and leads to a conditioned taste avoidance (CTA) if paired with a novel taste. Here, the effects of MFs on male and female rats were compared to determine whether there are sex differences in behavioral responses and whether these can be explained by ovarian steroid status. Rats were given 10-min access to a novel saccharin solution and then restrained within a 14-T magnet for 30 min. Locomotor activity after exposure was scored for circling and rearing. CTA extinction was measured with two-bottle preference tests. In experiment 1, males were compared with females across the estrous cycle after a single MF exposure. Females circled more and acquired a more persistent CTA than males; circling was highest on the day of estrus. In experiment 2, the effects of three MF exposures were compared among intact rats, ovariectomized females, and ovariectomized females with steroid replacement. Compared with intact rats, ovariectomy increased circling; estrogen replacement blocked the increase. Males acquired a stronger initial CTA but extinguished faster than intact or ovariectomized females. Thus the locomotor circling induced by MF exposure was increased in females and modulated by ovarian steroids across the estrous cycle and by hormone replacement. Furthermore, female rats acquired a more persistent CTA than male rats, which was not dependent on estrous phase or endogenous ovarian steroids.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 93%

Sex and estrous cycle differences in the behavioral effects of high-strength static magnetic fields: role of ovarian steroids

Cason¹,

DenBleyker²,

Ferrence³

et al. 2006

American Journal of Physiology-Regulatory, Integrative and Comp

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“…Prior research has reported both attenuated (Chambers, Sengstake, Yoder, & Thornton, 1981; Sherrill, Berthold, Koss, Juraska, & Gulley, 2011) and enhanced (Morales et al, 2014; Morales & Spear, 2013) sensitivity to aversive effects of drugs of abuse in adolescent and adult females when compared to their male counterparts. Current data support generally similar ontogenetic patterns of ethanol aversion, with early adolescents displaying reduced CTA compared to older animals in both sexes.…”

Section: Discussionmentioning

confidence: 98%

The ontogeny of ethanol aversion

Saalfield

Spear

2016

Physiology & Behavior

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Recent work has suggested separate developmental periods within the broader framework of adolescence, with data suggesting distinct alterations and vulnerabilities within these intervals. While previous research has suggested reduced sensitivity to the aversive effects of alcohol in adolescence relative to adults, a more detailed ontogeny of this effect has yet to be conducted. The adolescent brain undergoes significant transitions throughout adolescence, including in regions linked with drug reward and aversion. The current study aimed to determine the ontogeny of ethanol aversion by utilizing a conditioned taste aversion procedure at six different ages to test the hypothesis that the transitions into, through, and out of adolescence are associated with ontogenetic alterations in sensitivity to the aversive properties of ethanol. Non-deprived animals given Boost® as the conditioned stimulus (CS) were used in Experiment 1, whereas Experiment 2 used water-restricted animals provided with a saccharin/sucrose solution as the CS. In both experiments, an attenuated sensitivity to the aversive properties of ethanol was evident in adolescents compared to adults, although more age differences were apparent in water deprived animals than when a highly palatable CS was given to ad libitum animals. Overall, the data suggest an attenuated sensitivity to the aversive properties of ethanol that is most pronounced during pre- and early adolescence, declining thereafter to reach the enhanced aversive sensitivity of adults.

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“…Studies were performed using female Long-Evans rats (Charles River Laboratories) with body weights of 250-320 g at the time of surgery; while female rats condition somewhat more consistently than male rats (Chambers et al 1981), this fact in no way interferes with our results. Subjects were housed individually in an animal facility with a 12 h light/12 h dark cycle (lights out at 7 p.m.) with ad libitum access to standard chow.…”

Section: Subjectsmentioning

confidence: 97%

Hippocampal inactivation enhances taste learning

Stone¹,

Grimes²,

Katz³

2005

Learn. Mem.

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Learning tasks are typically thought to be either hippocampal-dependent (impaired by hippocampal lesions) or hippocampal-independent (indifferent to hippocampal lesions). Here, we show that conditioned taste aversion (CTA) learning fits into neither of these categories. Rats were trained to avoid two taste stimuli, one novel and one familiar. Muscimol infused through surgically implanted intracranial cannulae temporarily inactivated the dorsal hippocampus during familiarization, subsequent CTA training, or both. As shown previously, hippocampal inactivation during familiarization enhanced the effect of that familiarization on learning (i.e., hippocampal inactivation enhanced latent inhibition of CTA); more novel and surprising, however, was the finding that hippocampal inactivation during training sessions strongly enhanced CTA learning itself. These phenomena were not caused by specific aspects of our infusion technique-muscimol infusions into the hippocampus during familiarization sessions did not cause CTAs, muscimol infusions into gustatory cortex caused the expected attenuation of CTA, and hippocampal inactivation caused the expected attenuation of spatial learning. Thus, we suggest that hippocampal memory processes interfere with the specific learning mechanisms underlying CTA, and more generally that multiple memory systems do not operate independently.

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Sexually dimorphic acquisition of a conditioned taste aversion in rats: Effects of gonadectomy, testosterone replacement and water deprivation☆

Cited by 45 publications

References 9 publications

Sex and estrous cycle differences in the behavioral effects of high-strength static magnetic fields: role of ovarian steroids

Sex and estrous cycle differences in the behavioral effects of high-strength static magnetic fields: role of ovarian steroids

The ontogeny of ethanol aversion

Hippocampal inactivation enhances taste learning

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