Sexually deviant behavior in Klinefelter's syndrome

Mosier, H. David; Scott, Lawrence; Dingman, Harvey F.

doi:10.1016/s0022-3476(60)80256-9

Cited by 39 publications

(5 citation statements)

References 10 publications

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“…44,1965 Table 3 gives the cephalometric angles selected from Reidel's tables to show maxillomandibular-cranial interrelationships in people with "excellent occlusion." Table 4 lists the same angles for the individuals with X-chromosome anomalies.…”

Section: Resultsmentioning

confidence: 99%

Effect of X-Chromosome Aneuploidy on Jaw Growth

1965

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It is now increasingly evident that chromosomal abnormalities underlie a goodly proportion of congenital abnormalities, between 5 and 15 per cent of children with congenital abnormalities showing evidence of chromosomal deletions or aberrations. Since dentofacial defects are particularly common in developmental abnormalities, and to an extent not in accordance with the concept of stage-specificity, the possible chromosomal basis of dentofacial defects represents a problem in its own right and, when the chromosomal type is known, provides new indications as to the role of chromosomes in controlling developmental timing. This report represents but an initial probe into a subject that holds great promise for future study. It is our sincere hope that this communication will stimulate further inquiry.Loss or duplication of chromosomes other than the exact multiple of the haploid complement is referred to as "aneuploidy." This may involve either the sex chromosomes (X and/or Y) or the autosomes (non-sex chromosomes). Deletion of one of the autosomes in both man and Drosophila appears to be lethal. Several distinct syndromes result from triplication of chromosomes in the 13-15, 18, and 21 groups, but we shall not discuss these here. We shall limit ourselves for the most part to consideration of syndromes that arise because of a gain or loss of X chromosomes. Surprisingly, these symptom complexes are not as rare as one might suppose. In newborns, the XXY or Klinefelter syndrome is present in 0.3 per cent, the XO chromatinnegative Turner syndrome is present in 0.03 per cent, and the XXX syndrome is present in 0.13 per cent.' In individuals institutionalized for mental retardation, the incidence rises to 1.0, 0.05, and 0.4 per cent, respectively.2 These institutions form, then, a ready source of these fascinating patients for study. Since the marked addition of extra X chromosomes (XXXX, XXXXY, and XXYY syndromes) appears to be associated with more severe mental retardation, these individuals are concentrated in this population. However, these syndromes are far less common than the XXY, XO, and XXX symptom complexes. Possibly the most efficient way to screen such a population for purposes of carrying on growth studies is by means of buccal smears for study of Barr bodies. The Barr body represents the tightly coiled or inactive X chromosome, and, since all X chromosomes in excess of one are thought to be "essentially inactive," there is one less Barr body than the number of X chromosomes. For example, individuals with XO (Turner syndrome)

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Section: Resultsmentioning

confidence: 99%

Effect of X-Chromosome Aneuploidy on Jaw Growth

1965

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“…Whilst it may be appropriate to begin androgen replacement therapy, treatments are rarely without side effects and it has been suggested that despite many men with Klinefelter's syndrome experiencing some form of sexual dysfunction, such replacement may increase their risk of sexual offending (Wakeling ; Mosier et al ; Harrison et al ). Further, there is currently no guidance for the management of patients in these circumstances.…”

Section: Introductionmentioning

confidence: 99%

Klinefelter's syndrome and sexual offending – A literature review

O'Donovan

Völlm

2017

Criminal Behav Ment Health

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“…Though not deliberately biased, the samples also were not truly random. There were 14 cases of Kline¬ felter's syndrome, 11 of transvestism, and two with both syndromes coexistent.…”

Section: Resultsmentioning

confidence: 99%

Cytogenetic and Psychosexual Ambiguity

Money¹

1964

Arch Gen Psychiatry

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Sexually deviant behavior in Klinefelter's syndrome

Cited by 39 publications

References 10 publications

Effect of X-Chromosome Aneuploidy on Jaw Growth

Effect of X-Chromosome Aneuploidy on Jaw Growth

Klinefelter's syndrome and sexual offending – A literature review

Cytogenetic and Psychosexual Ambiguity

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