Sexuality in premature ovarian insufficiency

Nappi, Rossella E.; Cucinella, Laura; Martini, Ellis; Rossi, Margherita Maria; Tiranini, Lara; Martella, Silvia; Bosoni, David; Cassani, Chiara

doi:10.1080/13697137.2019.1575356

Cited by 40 publications

(26 citation statements)

References 82 publications

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“…POI is a life-changing diagnosis carrying a high risk of psychosexual and psychosocial consequences 52 . The early hormonal deprivation contributes to the impairment of central and peripheral components of the sexual response, resulting in hypoactive sexual desire disorder and symptomatic vulvovaginal atrophy (VVA)/genitourinary syndrome of menopause 53 . Significant emotional and cognitive 'rebuilding' is required due to the multiple effects of POI, including infertility, potential early aging, and reduced self-esteem 54 .…”

Section: Psychosexual and Psychosocial Health In Women With Prematurementioning

confidence: 99%

“…Psychosexual and psychosocial symptoms in POI deserve more research in order to understand the complexity of factors involved in the burden of the condition and to establish a tailored treatment with hormonal and non-hormonal strategies in the long term 53,74 . Clinical judgment has to guide the choice of treatment with the aim of counteracting, whenever possible, androgen insufficiency 53 , either by prescribing transdermal estradiol at an adequate dosage 75 and/ or by using transdermal testosterone at the dosage typical of the physiological premenopausal range 76,77 . Other pharmacological and non-pharmacological treatments are identical to those used in typical postmenopausal women.…”

Section: Optimizing Psychosexual and Psychosocial Healthmentioning

confidence: 99%

“…Other pharmacological and non-pharmacological treatments are identical to those used in typical postmenopausal women. Cognitive behavioral and sexual interventions should be designed according to the specific needs of women with POI 53 .…”

Section: Optimizing Psychosexual and Psychosocial Healthmentioning

confidence: 99%

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Premature ovarian insufficiency: an International Menopause Society White Paper

et al. 2020

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The aim of this International Menopause Society White Paper on premature ovarian insufficiency (POI) is to provide the latest information regarding this distressing condition. The impact of POI has far-reaching consequences due to its impact on general, psychological, and sexual quality of life, fertility prospects, and long-term bone, cardiovascular, and cognitive health. Progress in fully understanding the etiology, diagnosis, and optimal management options has been slow thus far due to the complexity of the condition and fragmented research. Recent advances in epidemiological and genetic research have improved our understanding of this condition and randomized prospective trials are being planned to determine the intervention strategies, which will optimize quality of life and long-term well-being. The International Menopause Society has commissioned a number of experts at the forefront of their specialty to define the state of the art in the understanding of this condition, to advise on practical management strategies, and to propose future research strategies. It is hoped that a global task force will subsequently be convened in order to formulate a consensus statement across key societies, to accelerate date collection and analysis of a global POI registry, and to facilitate progress in the key defined areas of research.

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Section: Psychosexual and Psychosocial Health In Women With Prematurementioning

confidence: 99%

Section: Optimizing Psychosexual and Psychosocial Healthmentioning

confidence: 99%

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Premature ovarian insufficiency: an International Menopause Society White Paper

et al. 2020

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“…Indeed, endocrine chemotherapy, surgery and/or radiation may induce profound changes at urogenital levels which have to be timely recognized in the oncologic care (76, 77). Moreover, we lack data on VVA/GSM in women with spontaneous premature ovarian insufficiency, even though it is likely that the condition is more distressing due to the younger age of these patients (78). Older women and those who abstain from sexual activity may suffer even more of VVA/GSM with vaginal and introital stenosis, fusion of the labia minora to the labia majora, and other urogenital conditions (79).…”

Section: Key-elements Of Vva/gsm Diagnosismentioning

confidence: 99%

Addressing Vulvovaginal Atrophy (VVA)/Genitourinary Syndrome of Menopause (GSM) for Healthy Aging in Women

et al. 2019

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Vaginal health is an essential component of active and healthy aging in women at midlife and beyond. As a consequence of hormonal deprivation and senescence, the anatomy and function of urogenital tissues are significantly affected and vulvovaginal atrophy (VVA) may occur. In a high proportion of postmenopausal women, progressive and chronic VVA symptoms have a strong impact on sexual function and quality of life. The new definition of genitourinary syndrome of menopause (GSM) comprises genital symptoms (dryness, burning, itching, irritation, bleeding), sexual symptoms (dyspareunia and other sexual dysfunctions) and urinary symptoms (dysuria, frequency, urgency, recurrent urinary infections). Many variables (age, sexual activity and partnership status) influence the clinical impact VVA/GSM symptoms and attitudes of elderly women to consult for receiving effective treatments. Psychosocial factors play a critical role in sexual functioning, but the integrity of the urogenital system is as well important affecting many domains of postmenopausal women's health, including sexual function. Several international surveys have extensively documented the need to improve VVA/GSM management because of the strong impact on women's daily life and on couple's intimacy. Health care providers (HCPs) need to be proactive in the early recognition of VVA/GSM in order to preserve urogenital and sexual longevity, by using hormonal and non-hormonal strategies. The clinical diagnosis is based on genital examination to identify objective signs and on the use of subjective scales to rate most bothersome symptoms (MBS), especially vaginal dryness. Recent studies point to the importance of addressing VVA/GSM as a potential early marker of poor general health in analogy with vasomotor symptoms. Therefore, a standard of VVA/GSM care in elderly women is desirable to enhance physical, emotional and mental well-being.

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“…[ 23 ] Notwithstanding, nonhormonal alternatives such as lifestyle changes, psychosomatic techniques, diet management and supplementation, prescription therapy, and other strategies are, however, still available and useful. [ 24 ] These are nonhormonal alternatives. Many complementary and alternative therapies lack sufficient, high-quality evidence to support their prevention and treatment under different conditions.…”

Section: Introductionmentioning

confidence: 99%

A comparison of the efficacy and safety of complementary and alternative therapies for premature ovarian insufficiency

Zhang

et al. 2020

Medicine

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Background: With the increase in the incidence of premature ovarian insufficiency (POI) over the years, the ovarian function has become one of the integral aspects of research in reproductive medicine today. POI seriously affects the physical and mental health of women, especially reproductive health. Studies show both complementary and alternative therapies to be effective in treating POIs. However, consistency in conclusions is still far-fetched. In light of this, we will carry out a study to evaluate the effectiveness and safety of complementary and alternative therapies for POIs. We therefore develop a study protocol for a proposed network meta-analysis (NMA) and systematic review on POI. Methods: The following electronic bibliographic database will be searched: VIP database, Wanfang database, Chinese National Knowledge Infrastructure (CNKI), The Cochrane Library, PubMed, EMBASE and Web of Science from inception till 31 December 2019. A search at the World Health Organization (WHO) International Clinical Trials Registry Platform will also be done. Subsequently, the searched data will undergo independent screening, retrieving, and risk of bias assessment by 2 reviewers. Analysis will be performed on included studies using the NMA technique. Next, the primary outcomes will be compared using ADDIS 1.16.5 and Stata 15.0. Results: The safety and effectiveness of alternative and complementary therapies used in the treatment of POI will be compared and evaluated. Conclusion: This work will provide high-quality evidence for clinicians in the field to build on for best practices in effective interventions (complementary and alternative therapies) for POI. Ethics and dissemination: This NMA is a secondary research which based on some previously published data. Therefore, the ethical approval was not necessary. PROSPERO registration number: CRD42020163873

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Sexuality in premature ovarian insufficiency

Cited by 40 publications

References 82 publications

Premature ovarian insufficiency: an International Menopause Society White Paper

Premature ovarian insufficiency: an International Menopause Society White Paper

Addressing Vulvovaginal Atrophy (VVA)/Genitourinary Syndrome of Menopause (GSM) for Healthy Aging in Women

A comparison of the efficacy and safety of complementary and alternative therapies for premature ovarian insufficiency

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