Sexual transmission of human papillomaviruses in heterosexual and male homosexual couples, studied by DNA hybridisation.

Wickenden, Colin; Hanna, Nabil; Taylor‐Robinson, David; Harris, J. R. W.; Bellamy, Christopher; Carroll, Patrick; Malcolm, Alan D. B.; Coleman, D. V.

doi:10.1136/sti.64.1.34

Cited by 21 publications

(16 citation statements)

References 13 publications

(4 reference statements)

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“…34 The exact infectivity of each of these states is unclear, and clinicians cannot tell patients definitively whether they are more infectious when warts are present or whether treatment results in a reduction in risk for the transmission of HPV to sex partners. 34 Infectivity of HPV is associated with detectable viral load, 31,32,38 and the treatment of warts has been shown to reduce tissue viral load. Many clinicians have therefore hypothesized that treating anogenital warts decreases infectivity.…”

Section: Transmission and Infectivitymentioning

confidence: 99%

Human papillomavirus–related genital disease in the immunocompromised host

Gormley

Kovarik

2012

Journal of the American Academy of Dermatology

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Human papillomavirus (HPV) is responsible for common condyloma acuminata and a number of premalignant and malignant anogenital lesions. These conditions are of particular concern in immunocompromised individuals who have higher risk of malignant transformation and are more difficult to treat. This is part I of a two-part review that will highlight the cutaneous features of condyloma acuminata and vaginal, vulvar, penile, and anal intraepithelial neoplasias, with an emphasis on presentation of these HPV-mediated diseases in the immunocompromised host. Counseling patients about these conditions requires a thorough understanding of the epidemiology, natural history of HPV, transmission and infectivity, risk of malignancy, and the role of the host immune response in clearing HPV lesions. Part II will provide an updated review of available treatments, with a focus on recent advances and the challenges faced in successfully treating HPV lesions in immunocompromised patients.

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Section: Transmission and Infectivitymentioning

confidence: 99%

Human papillomavirus–related genital disease in the immunocompromised host

Gormley

Kovarik

2012

Journal of the American Academy of Dermatology

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“…Such groups are likely to be biased samples and may not reflect the general population prevalence and concordance rates. Most studies evaluating concordance have focused exclusively on genital infection between heterosexual partners who also had either HPV infection or an HPV-related disease rather than on healthy couples [41][42][43][44][45] . The outcome of these investigations is one of mixed results in the degree of concordance between partners.…”

Section: Discussionmentioning

confidence: 99%

HPV Prevalence and Concordance in the Cervix and Oral Cavity of Pregnant Women

Smith

Ritchie

Yankowitz

et al. 2000

Infectious Diseases in Obstetrics and Gynecology

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Objectives: This investigation examined human papillomavirus (HPV) in pregnant women in order to characterize viral prevalence, types and concordance between infection in the cervix and in the oral cavity. Methods: A total of 577 pregnant women seeking routine obstetric care were evaluated for HPV infection in their cervix during gestation and immediately before delivery, and in the oral cavity during gestation. Male partners present during the gestational clinic visit also provided a specimen from their oral cavity. HPV assessment was performed by PCR, dot blot hybridization and DNA sequencing. A sexual and health questionnaire was completed by the pregnant women. Results: HPV prevalence in women was 29% in the cervix and 2.4% in the oral cavity. Among those with both gestational and delivery specimens, 35% were infected at least once and 20% had infection at both intervals. At delivery, 68% of infected women had an oncogenic HPV type in the cervix. There was no type-specific HPV concordance between the two cervical specimens, nor cervical and oral results in women, nor with cervical and oral findings between partners. Conclusion: The lack of association in HPV positivity and types between the cervix and oral cavity in these women suggests that self-inoculation is uncommon. This source of infection does not appear to be from oral contact with a current male partner, since there also was no concordance between partners. These results suggest either other modes of HPV transmission or differences in susceptibility to HPV infection or its clearance in the oral cavity and genital mucosa.

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“…In addition, only a fraction of sexual partners of condyloma patients develop clinically manifest condylomas [10,11].…”

Section: Discussionmentioning

confidence: 99%

High prevalence of atopy suggesting a role as co‐factor in the clinical manifestation of condylomata acuminata

Ruzicka¹,

Geltinger²

1995

Acad Dermatol Venereol

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Background A high proportion of those infected with human papilloma virus remain asymptomatic. The co-factors predisposing to the clinical manifestation of condylomata acuminata are unknown. Atopy represents a minimal form of cellular immune deficiency and shows a high association with mucocutaneous infections. Its role in condylomata acuminata has never been investigated.Objectives To determine the role of atopy in the manifestation of condylomata acuminata.Design The presence of predisposing factors was assessed by clinical data, and serological, microbiological and proctological investigations. Atopy was evaluated by a standardised procedure, and an atopy score calculated and correlated with extent, duration and relapse rate of condylomata acuminata.Subjects Fifty-eight patients with condylomata acuminata were investigated at the Department of Dermatology of the University of Munich.Results A high proportion of patients showed predisposing local factors, such as coexistent infections, anal eczema or haemorrhoids. Many patients showed stigmata of atopy. A positive association was seen between atopy score and relapse of condylomata acuminata. The presence of atopy could be identified as a predisposing factor.Conclusions Atopy is common in patients with condylomata acuminata and may represent a co-factor for the development of clinically evident papillomas in persons infected with HPV. and offer an explanation for the high relapse rate of condylomata acuminata.

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Sexual transmission of human papillomaviruses in heterosexual and male homosexual couples, studied by DNA hybridisation.

Cited by 21 publications

References 13 publications

Human papillomavirus–related genital disease in the immunocompromised host

Human papillomavirus–related genital disease in the immunocompromised host

HPV Prevalence and Concordance in the Cervix and Oral Cavity of Pregnant Women

High prevalence of atopy suggesting a role as co‐factor in the clinical manifestation of condylomata acuminata

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