Sexual and gender minority (SGM) populations experience disadvantages in physical health, mental health, and socioeconomic status relative to cisgender heterosexual populations. However, extant population research has tended to use objective measures and ignore subjective measures, examined well-being outcomes in isolation, and lacked information on less well studied but possibly more disadvantaged SGM subgroups. In this study, we use Gallup's National Health and Well-Being Index, which permits identification of gay/lesbian, bisexual, queer, same-gender-loving, those who identify as more than one sexual identity, transgender men, transgender women, and nonbinary/genderqueer populations. We estimate bivariate associations and ordinary least-squares regression models to examine differences along five dimensions of well-being: life purpose, residential community belonging, physical and mental health, financial well-being, and social connectedness. The results reveal that most SGM groups experience stark disadvantages relative to heterosexuals and cisgender men, which are most pronounced among bisexual, queer, and nonbinary/genderqueer populations. Intergroup and intragroup variations illuminate even greater disparities in well-being than prior research has uncovered, bringing us closer to a holistic profile of SGM well-being at the population level.