Sexual Impairment in Psychiatric Inpatients: Focus on Depression

Cohen, Simon; Ku, Kühn; Bender, Stephan; Erfurth, Andreas; Gastpar, Markus; Murafi, A; Rothermundt, Matthias; Signerski, J; Sträter, Birgitta; Teusch, Ludwig; Weig, Wolfgang; Welling, A; Westheide, Jens; Tj, Huber

doi:10.1055/s-2007-970143

Cited by 37 publications

(37 citation statements)

References 26 publications

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“…In their study of incontinent women <30 years old, 16% considered UI extremely embarrassing or humiliating, 6% report feelings of frustration and/or depression, and up to 9% were using antidepressants and/or avoiding venturing outside their home. Interestingly, these depressive factors have also been implicated in women with sexual dysfunction [50].…”

Section: Resultsmentioning

confidence: 99%

Premenopausal Women with Sexual Dysfunction: The Need for a Bladder Function History

Mehta¹,

Bachmann²

2008

The Journal of Sexual Medicine

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Introduction Despite the high prevalence of both female sexual problems and bladder dysfunction in the premenopausal population, sexual history forms used in primary care offices rarely include questions about the impact of bladder dysfunction on sexual health. Aim To provide a review of the literature that illustrates the relationship between bladder problems and sexual performance of premenopausal women. Main Outcome Measures To objectively support by a review of the literature the need for a complete bladder history in when evaluating premenopausal women with female sexual dysfunction. Methods Pubmed was searched for all articles (from November 1980 to June 2007) that reported on the effect bladder dysfunction has on premenopausal female sexual function. Results The scant literature available strongly suggested that bladder dysfunction is a contributor to sexual dysfunction and that this medical concern should be considered in all women, regardless of age who present with sexual complaints. Conclusion Further studies need to be conducted in order to solidify a direct causal relationship between bladder dysfunction and premenopausal female sexuality. These studies should include a larger sample size, clearly defined types of sexual dysfunction and bladder dysfunction, and appropriate follow-up of patient responses using validated objective and subjective outcome modalities to confirm that the patient responses are factual.

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Section: Resultsmentioning

confidence: 99%

Premenopausal Women with Sexual Dysfunction: The Need for a Bladder Function History

Mehta¹,

Bachmann²

2008

The Journal of Sexual Medicine

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“…Again, a double-blind crossover trial found that amitriptyline-fluoxetine combination improved pain scores and total FIQ scores more than either drug alone and more than placebo [28]. Our group added pregabalin to fibromyalgia patients already improved by quetiapine and found that pain and tiredness after awakening subscales of the FIQ, as well as the physical component of the SF-12, additionally improved with quetiapine plus pregabalin combination [29]; the results of this study were similar to those obtained with the combination of pregabalin and trazodone in the present study. Recently, an experimental study has shown, in an animal model of fibromyalgia, a potent antihyperalgesic effect of tramadol combined with milnacipran [30].…”

Section: Discussionmentioning

confidence: 99%

Trazodone plus pregabalin combination in the treatment of fibromyalgia: a two-phase, 24-week, open-label uncontrolled study

Calandre

Morillas-Arques

Molina-Barea

et al. 2011

BMC Musculoskelet Disord

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BackgroundAlthough trazodone is frequently used by fibromyalgia patients, its efficacy on this disease has not been adequately studied. If effective, pregabalin, whose beneficial effects on pain and sleep quality in fibromyalgia have been demonstrated, could complement the antidepressant and anxiolytic effects of trazodone. The aim of the present study was to assess the effectiveness of trazodone alone and in combination with pregabalin in the treatment of fibromyalgia.MethodsThis was an open-label uncontrolled study. Trazodone, flexibly dosed (50-300 mg/day), was administered to 66 fibromyalgia patients during 12 weeks; 41 patients who completed the treatment accepted to receive pregabalin, also flexibly dosed (75-450 mg/day), added to trazodone treatment for an additional 12-week period. Outcome measures included the Fibromyalgia Impact Questionnaire (FIQ), the Pittsburgh Sleep Quality Index (PSQI), the Beck Depression Inventory (BDI), the Hospital Anxiety and Depression Scale (HADS), the Brief Pain Inventory (BPI), the Short-Form Health Survey (SF-36), and the Patients' Global Improvement scale (PGI). Emergent adverse reactions were recorded. Data were analyzed with repeated measures one-way ANOVA and paired Student's t test.ResultsTreatment with trazodone significantly improved global fibromyalgia severity, sleep quality, and depression, as well as pain interference with daily activities although without showing a direct effect on bodily pain. After pregabalin combination additional and significant improvements were seen on fibromyalgia severity, depression and pain interference with daily activities, and a decrease in bodily pain was also apparent. During the second phase of the study, only two patients dropped out due to side effects.ConclusionsTrazodone significantly improved fibromyalgia severity and associated symptomatology. Its combination with pregabalin potentiated this improvement and the tolerability of the drugs in association was good.Trial RegistrationClinicalTrials.gov: NCT00791739

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“…A total of 79 randomized, controlled and double-blind trials conducted between 1989 and 2005 with the following antidepressants were identifi ed and included in our analysis: duloxetine (4), milnacipran (10), mirtazapine (19), nefazodone (11), reboxetine (7) and venlafaxine (28). The methods sections of the reviewed research papers were searched for the methodology of adverse event assessment.…”

Section: Methodsmentioning

confidence: 99%

A Review of the Assessment of Antidepressant-Induced Sexual Dysfunction used In Randomized, Controlled Clinical Trials

Em¹

2007

Pharmacopsychiatry

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Sexual Impairment in Psychiatric Inpatients: Focus on Depression

Cited by 37 publications

References 26 publications

Premenopausal Women with Sexual Dysfunction: The Need for a Bladder Function History

Premenopausal Women with Sexual Dysfunction: The Need for a Bladder Function History

Trazodone plus pregabalin combination in the treatment of fibromyalgia: a two-phase, 24-week, open-label uncontrolled study

A Review of the Assessment of Antidepressant-Induced Sexual Dysfunction used In Randomized, Controlled Clinical Trials

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