Sexual health in hematopoietic stem cell transplant recipients

Li, Zhuoyan; Mewawalla, Prerna; Stratton, Pamela; Yong, Agnes S. M.; Shaw, Bronwen E.; Hashmi, Shahrukh K.; Jagasia, Madan; Mohty, Mohamad; Majhail, Navneet S.; Savani, Bipin N.; Rovó, Alicia

doi:10.1002/cncr.29675

Cited by 53 publications

(38 citation statements)

References 60 publications

(108 reference statements)

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“…The few longitudinal studies of sexual health after HCT consistently indicate that sexual dysfunction and sexual dissatisfaction are common (49). The incidence of long-term sexual dysfunction in male transplant survivors ranges from 6–46% and in female survivors from 33–80% (29, 50–52).…”

Section: Resultsmentioning

confidence: 99%

National Institutes of Health Hematopoietic Cell Transplantation Late Effects Initiative: The Patient-Centered Outcomes Working Group Report

Bevans

El‐Jawahri

Tierney

et al. 2017

Biology of Blood and Marrow Transplantation

120

139

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In 2015 the National Institutes of Health (NIH) convened six working groups to address the research needs and best practices for patient-centered late effects of hematopoietic stem cell transplantation (HCT) survivors. The Patient-Centered Outcomes Working Group, charged with summarizing the HRQOL evidence base, used a scoping review approach to efficiently survey the large body of literature in adult and pediatric HCT survivors over 1 year after transplantation. The goals of this paper are to 1) summarize the current literature describing patient-centered outcomes (PCO) in survivors including the various dimensions of healthrelated quality of life affected by HCT and describe interventions tested to improve these outcomes; 2) highlight areas with sufficient evidence allowing for integration into standard practice; 3) address methodological issues that restrict progress in this field; 4) identify major gaps to guide future research; and 5) specify priority research recommendations. PCOs were summarized within physical, psychological, social and environmental domains, as well as for adherence to treatment, and health behaviors. Interventions to improve outcomes were evaluated for evidence of efficacy, although few interventions have been tested in long-term HCT survivors. Methodologic issues defined included lack of consistency in the selection of PCO measures, along with the absence of a standard for timing, frequency, and mode of administration. Recommendations for HCT survivorship care included: integration of annual screening of PCOs; use of evidence based practice guidelines; and provision of treatment summaries and survivorship care plans after HCT. Three priority research recommendations included: 1) Design and test risk-targeted interventions with dose intensity modulation matching the needs of HCT survivors with priority domains including sexual dysfunction, fatigue, sleep disruption, non-adherence to medications & recommended health care, health behaviors including physical inactivity and healthy eating, and psychological dysfunction, with particular consideration of novel technologies to reach HCT survivors distant from their transplant centers, 2) Design a consensus based methodologic framework for outcomes evaluation, and 3) Evaluate and compare existing practices for integrating PCOs screening and interventions across HCT survivorship programs.

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Section: Resultsmentioning

confidence: 99%

National Institutes of Health Hematopoietic Cell Transplantation Late Effects Initiative: The Patient-Centered Outcomes Working Group Report

Bevans

El‐Jawahri

Tierney

et al. 2017

Biology of Blood and Marrow Transplantation

120

139

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“…Women who undergo allogeneic HSCT report a multitude of side effects that represent significant and often long-term threats to sexual wellbeing (Dyer et al, 2016;Li et al, 2015;Yi & Syrjala, 2009). …”

Section: Impacts Of Hsct On Sexual Wellbeingmentioning

confidence: 99%

“…In fact, research indicates that sexual dysfunction and fertility issues are among the most common sequelae of HSCT (Dyer et al, 2016;Li et al, 2015;Yi & Syrjala, 2009 …”

Section: Impacts Of Hsct On Sexual Wellbeingmentioning

confidence: 99%

“…). genital) effects(Li et al, 2015). Allogenic bone marrow transplantation is associated with graft-versus-host disease (GVHD), a chronic condition that can have systemic or local (e.g.…”

mentioning

confidence: 99%

“…According to results of a recent study, 26%-83% of female haematopoietic stem cell transplant recipients experience at least one vaginal or sexual health challenge(Dyer et al, 2016). Although systemic manifestations, including issues with skin, gastrointestinal tract and multiple organ systems, may indirectly impact sexual wellbeing, localised GVHD disease within the genitals and mucous membranes often directly and severely disrupts sexual functioning(Li et al, 2015;Yi & Syrjala, 2009). genital) effects(Li et al, 2015).…”

mentioning

confidence: 99%

See 2 more Smart Citations

A comprehensive review of sexual health concerns after cancer treatment and the biopsychosocial treatment options available to female patients

2017

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The repercussions of cancer diagnosis and treatment profoundly impact the sexual wellbeing of women prior to, during, and following cancer treatment. Sexual health concerns are often under-addressed within clinical and research settings, and information tends to be limited to women with breast or gynecological cancers. In this narrative literature review, the authors critically evaluate research published between 1990 and 2016, pertaining to sexual health concerns of women diagnosed with cancer, of any type or stage, and to the psychosocial and biomedical interventions that currently exist for the treatment of sexual health-related side-effects (e.g. vaginal dryness, dyspareunia and vulvo-vaginal atrophy). The findings of 109 published articles are discussed and summarised according to four central themes: how cancer affects female sexual wellbeing; physical impacts of cancer diagnosis and treatment; emotional impacts of cancer diagnosis and treatment; and interventions for sexual dysfunction. Suggestions to enhance research and clinical practice in relation to the sexual health concerns of women following cancer treatments are also presented. Concerns pertaining to women's sexual health are diverse, multiple, and pervade all types and stages of cancer. Several evidence-based psychosocial and biomedical interventions exist to help women manage physical and psychosocial ramifications of cancer diagnosis and treatment.

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