Sexual functions in women with focal epilepsy: Relationship to demographic, clinical, hormonal and psychological variables

Hamed, Sherifa A.; Attiah, Fadia Ahmed; Gabra, Romany H.; Sherif, Tahra Kamel

doi:10.1016/j.clineuro.2020.105697

Cited by 4 publications

(5 citation statements)

References 32 publications

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“…ASMs may be safer than traditional drugs, and their reproductive endocrine effects have not been extensively studied. In addition, the effects of epilepsy and anti-epileptic drugs on reproductive endocrine function vary with factors such as the type of epilepsy, the age at onset of seizures, the age when treatment was initiated, and the types TABLE 1 | The influence of anti-seizure medications (ASMs) on the hypothalamic-pituitary-ovarian (HPO) axis (5,14,16,72,134,140,142,143).…”

Section: Discussionmentioning

confidence: 99%

“…Part of the reason for these abnormalities may be the direct inhibition of the function of the hypothalamic-pituitary axis (141). The incidence of PCO in women treated with OXC is as high as 60%, and there will also be abnormal levels of dehydroepiandrosterone, testosterone, and SHBGs (142,143). OXC can stimulate the GnRH neurons to release GnRH, thereby promoting the pituitary gland and testicles to secrete and release large amounts of FSH, LH, and testosterone (144).…”

Section: Carbamazepine and Oxcarbazepinementioning

confidence: 99%

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Research Progress on the Effect of Epilepsy and Antiseizure Medications on PCOS Through HPO Axis

Zhang

Wei

et al. 2021

Front. Endocrinol.

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Epilepsy is a common chronic neurological disease that manifests as recurrent seizures. The incidence and prevalence of epilepsy in women are slightly lower than those in men. Polycystic ovary syndrome (PCOS), a reproductive endocrine system disease, is a complication that women with epilepsy are susceptible to, and its total prevalence is 8%–13% in the female population and sometimes as high as 26% in female epilepsy patients. The rate of PCOS increased markedly in female patients who chose valproate (VPA), to 1.95 times higher than that of other drugs. In addition, patients receiving other anti-seizure medications (ASMs), such as lamotrigine (LTG), oxcarbazepine (OXC), and carbamazepine (CBZ), also have reproductive endocrine abnormalities. Some scholars believe that the increase in incidence is related not only to epilepsy itself but also to ASMs. Epileptiform discharges can affect the activity of the pulse generator and then interfere with the reproductive endocrine system by breaking the balance of the hypothalamic–pituitary–ovarian (HPO) axis. ASMs may also cause PCOS-like disorders of the reproductive endocrine system through the HPO axis. Moreover, other factors such as hormone metabolism and related signalling pathways also play a role in it.

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Section: Discussionmentioning

confidence: 99%

Section: Carbamazepine and Oxcarbazepinementioning

confidence: 99%

Research Progress on the Effect of Epilepsy and Antiseizure Medications on PCOS Through HPO Axis

Zhang

Wei

et al. 2021

Front. Endocrinol.

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“…Hamilton depression scale (HAMD) [ 30 ] was used to assess the depression level of subjects. There was a total of 5 aspects and 17 items.…”

Section: Methodsmentioning

confidence: 99%

Psychosocial Factors and Psychological Characteristics of Personality of Patients with Chronic Diseases Using Artificial Intelligence Data Mining Technology and Wireless Network Cloud Service Platform

2022

Computational Intelligence and Neuroscience

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It was to explore the application value of health cloud service platform based on data mining algorithm and wireless network in the analysis of psychosocial factors and psychological characteristics of personality of patients with chronic diseases. Based on the demand analysis of cloud service platform for chronic diseases, a health cloud service platform including three modules was established: support layer, application layer, and interaction layer; and K-means algorithm and Apriori algorithm were used to mine and process data. The changes of pulse wave and EEG signal of epileptic seizures before and after processing by wireless network health cloud service platform were analyzed. 42 patients with idiopathic generalized epilepsy were selected as the research subjects, and 40 volunteers with normal physical examination during the same period were selected as the control group. The differences in the basic clinical characteristics data, Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD), Symptom Checklist 90 (SCL-90), and Eysenck Personality Questionnaire-Revision Short Scale for Chinese (EPQ-RSC) were compared between the two groups. It was found that the initial EEG signals of epileptic patients had noise pollution before and after the seizure, and the noise in the EEG signals was filtered out after digital technology processing in the cloud service platform. The maximum number of epileptic patients aged 18∼30 years was 17 (40.48%), and the mean scores of HAMD and HAMA scales in the epileptic group were significantly higher than those in the control group ( P < 0.001 ). The total score of SCL-90, somatization, obsessive-compulsive symptoms, interpersonal sensitivity, depression, anxiety, hostility, phobic anxiety, paranoid ideation, and psychosis in the epilepsy group were obviously higher than those in the control group ( P < 0.01 ). The mean value of EPQ-RSC and neuroticism (N) was clearly higher ( P < 0.05 ), the mean value of extroversion (E) was significantly lower ( P < 0.01 ), and the mean value of Lie Scale was significantly higher ( P < 0.05 ) in the epileptic group in contrast with those in the control group. It indicates that the cloud service platform for chronic diseases based on artificial intelligence data mining technology and wireless network has potential application value. Epilepsy patients with chronic diseases should be paid more attention to their psychosocial factors and psychological characteristics of personality in the treatment process.

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“…OXC can be used as a monotherapy or adjunctive treatment for partial epilepsy and is also indicated for affective-psychotic disorders ( 21 , 50 ). The study by Luef et al ( 51 ) noted that OXC stimulates GnRH neurons and that the released GnRH promotes the secretion and release of large amounts of luteinizing hormones, follicle-stimulating hormones, and testosterone from the pituitary gland and testes, and that the incidence of polycystic ovaries in women treated with OXC is as high as 60%.…”

Section: Discussionmentioning

confidence: 99%

“…Another phenomenon of interest and discussion in the choice of clinical medication is that Joffe et al found that PCOS caused by VPA resolved in three quarters of patients after discontinuation of the medication through a follow-up of patients (49). Further observational trials are needed to determine whether VPA-induced PCOS is temporary and whether it can resolve on its own after discontinuation.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the probability of four anticonvulsant mood stabilizers to facilitate polycystic ovary syndrome in women with epilepsies or bipolar disorder—A systematic review and meta-analysis

et al. 2023

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BackgroundPatients treated with anticonvulsant mood stabilizers have a higher incidence of polycystic ovary syndrome (PCOS). However, there is no comparison between different anticonvulsant mood stabilizers. The purpose of this study was to systematically evaluate the prevalence of PCOS in women taking anticonvulsant mood stabilizers and compare the probability of PCOS caused by different anticonvulsant mood stabilizers.MethodsFive databases, namely PubMed, Embase, Web of Science, Cochrane Library, and Clinical Trials, were searched for literature on anticonvulsant mood stabilizers and PCOS published up to October 28, 2022. This meta-analysis was performed using Revman 5.4, Stata 14.0, and R4.1.0, and effect size pooling was performed in fixed- or random-effects models based on the results of I2 and Q-test, and the surface under the cumulative ranking curve (SUCRA) was used for analysis to assess the cumulative probability of drug-induced PCOS. Publication bias was assessed by funnel plot Egger's test and meta regression.ResultsTwenty studies with a total of 1,524 patients were included in a single-arm analysis, which showed a combined effect size (95% CI) of 0.21 (0.15–0.28) for PCOS in patients taking anticonvulsant mood stabilizers. Nine controlled studies, including 500 patients taking medication and 457 healthy controls, were included in a meta-analysis, which showed OR = 3.23 and 95% CI = 2.19–4.76 for PCOS in women taking anticonvulsant mood stabilizers. Sixteen studies with a total of 1416 patients were included in a network meta-analysis involving four drugs, valproate (VPA), carbamazepine (CBZ), oxcarbazepine (OXC), and lamotrigine (LTG), and the results of the network meta-analysis showed that VPA (OR = 6.86, 95% CI = 2.92–24.07), CBZ (OR = 3.28, 95% CI = 0.99–12.64), OXC (OR = 4.30, 95% CI = 0.40–49.49), and LTG (OR = 1.99, 95% CI = 0.16–10.30), with cumulative probabilities ranked as VPA (90.1%), OXC (63.9%), CBZ (50.1%), and LTG (44.0%).ConclusionThe incidence of PCOS was higher in female patients treated with anticonvulsant mood stabilizers than in the healthy population, with VPA having the highest likelihood of causing PCOS. The most recommended medication when considering PCOS factors is LTG.Systematic review registrationidentifier: CRD42022380927

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Sexual functions in women with focal epilepsy: Relationship to demographic, clinical, hormonal and psychological variables

Cited by 4 publications

References 32 publications

Research Progress on the Effect of Epilepsy and Antiseizure Medications on PCOS Through HPO Axis

Research Progress on the Effect of Epilepsy and Antiseizure Medications on PCOS Through HPO Axis

Psychosocial Factors and Psychological Characteristics of Personality of Patients with Chronic Diseases Using Artificial Intelligence Data Mining Technology and Wireless Network Cloud Service Platform

Comparison of the probability of four anticonvulsant mood stabilizers to facilitate polycystic ovary syndrome in women with epilepsies or bipolar disorder—A systematic review and meta-analysis

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