Sexual functions after high-dose chemotherapy in survivors of germ cell tumors

Abstract

Summary:We investigated the changes in sexual function in male patients with germ cell tumor continuously disease free after one or two courses of high-dose chemotherapy with hematopoietic stem cell support. A questionnaire was mailed to 35 patients, and 30 patients sent it back. Sexuality was considered a problem by 10 patients (33%), but no patients considered sexuality a major problem. Erection was more difficult to achieve in seven patients (23%) and 10 patients (33%) experienced increased difficulty in maintaining an erection. Eight patients (27%) had the experience of less intensive and less frequent orgasm. In all, 13 patients (43%) thought that both the disease and treatment had worsened their sexual capacity, but 20 patients (67%) were satisfied with their sex life. Most of the patients (63%) considered that insufficient information and counselling had been given by their physicians about the sexual sequelae of therapy. However, the amount of information about the disease and treatment was considered good by 77 and 80% of the patients, respectively. This study shows that 27% of patients were not content with their ability to attain sexual satisfaction due to the illness or its treatment. Communication is an important issue and better information tools could lead to improved compliance in these patients.

Sexuality After Hematopoietic Stem Cell Transplantation

“…In a one year longitudinal study of sexual functioning of HSCT patients who had received high dose chemotherapy as part of their conditioning regimen, just under half of the patients reported sexual dysfunction prior to treatment 36. This finding has been supported in another study of male HSCT survivors 21. To decrease potential hesitation to raise questions or discuss sexual problems, routine assessment of sexual function by designated health care providers needs to be provided to all patients 9,22.…”

“…The type and dose of chemotherapy are factors to consider when identifying potential effects of treatment 13,21. In some studies comparing chemotherapy alone to HSCT, those patients who have received only chemotherapy report less sexual dysfunction in all phases of the sexual response cycle 22.…”

Is Chemotherapy Related with Erectile Dysfunction in Non-Urologic Cancer Patients?

“…Generally, having a diagnosis of cancer is regarded as a critical point in life associated with long-lasting psychological effects. Men may still suffer from anxiety, depression, and decreased sexual arousal, even a decade after neoplasm treatment (10).…”