Sexual Functioning in Patients with Chronic Renal Failure

Abram, Harry S.; Hester, Larry R.; Sheridan, William F.; Epstein, Gerald

doi:10.1007/978-1-4613-3973-1_32

Cited by 26 publications

(37 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…30 Sexual difficulties of uremic patients are often worse at the stage when hemodialysis occurs, with a lowered frequency of intercourse, and reduced sexual desire. 31 Amenorrheic dialysis patients may have low estradiol levels. Low estradiol levels may lead to vaginal atrophy and dryness, thereby resulting in discomfort during intercourse.…”

Section: Female Sexual Dysfunctionmentioning

confidence: 98%

Endocrine Complications of Chronic Kidney Disease

Singh

Raed

Kari

2015

Chronic Renal Disease

View full text Add to dashboard Cite

Section: Female Sexual Dysfunctionmentioning

confidence: 98%

Endocrine Complications of Chronic Kidney Disease

Singh

Raed

Kari

2015

Chronic Renal Disease

View full text Add to dashboard Cite

“…Studies from the 1970s showed that libido and sexual function decline dramatically in the majority of uremic men already before dialysis initiation, with little or no change during dialysis therapy, but substantial, although not universal, improvement after renal transplantation (66)(67)(68)(69)(70)(71). In recent studies the sexual dysfunction prevalence estimates range from 9% in predialysis patients to 70%-80% in those receiving dialysis (50,72).…”

Section: Implications For Sex Drive Libido and Erectile Functionmentioning

confidence: 99%

Gonadal dysfunction in men with chronic kidney disease: clinical features, prognostic implications and therapeutic options

Iglesias

Carrero²,

Díez³

2011

104

View full text Add to dashboard Cite

Gonadal dysfunction is a frequent finding in men with chronic kidney disease and with end-stage renal disease. Testosterone deficiency, usually accompanied by elevation of serum gonadotropin concentrations, is present in 26-66% of men with different degrees of renal failure. Uremia-associated hypogonadism is multifactorial in its origin, and rarely improves with initiation of dialysis, although it usually normalizes after renal transplantation. Experimental and clinical evidence suggests that testosterone may have important clinical implications with regards to kidney disease progression, derangements in sexual drive, libido and erectile dysfunction, development of anemia, impairment of muscle mass and strength, and also progression of atherosclerosis and cardiovascular disease. Additionally, low testosterone levels in hemodialysis patients have been associated with increased mortality risk in some studies. Currently, we count with available therapeutic options in the management of uremic hypogonadism, from optimal delivery of dialysis and adequate nutritional intake, to hormone replacement therapy with different testosterone preparations. Other potential options for treatment include the use of antiestrogens, dopamine agonists, erythropoiesis-stimulating factors, vitamins, essential trace elements, chorionic gonadotropin and renal transplantation. Potential adverse effects of androgen replacement therapy in patients with kidney disease comprise, however, erythrocytosis, prostate and breast cancer growth, reduced fertility, gynecomastia, obstructive sleep apnea and fluid retention. Androgen preparations should be used with caution with stringent monitoring in uremic men. Although there are encouraging data suggesting plausible benefits from testosterone replacement therapy, further studies are needed with regards to safety and effectiveness of this therapy.

show abstract

“…ED is the persistent inability to achieve and/or maintain an erection for satisfactory sexual activity [4]. Since the 1970s, when the first works on sexual functioning in uremic patients were published, several studies have highlighted the high prevalence of sexual dysfunction among patients of both sexes with CRF [1,[6][7][8][9][10]. In these reports, the different methods were used for the evaluation of ED.…”

Section: Introductionmentioning

confidence: 99%