Sexual function through decades: association with androgens and cardiometabolic features

Yoldemir, Tevfik; Garibova, N; Atasayan, Kemal

doi:10.1080/13697137.2020.1742683

Cited by 5 publications

(4 citation statements)

References 56 publications

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“…Mounting FAI due to abating SHBG production that is down-regulated by opposing T rise and E2 decline, is considered as the best predictor of adverse outcomes (MS and cardiovascular diseases) in postmenopause. There was interesting assumption that also rising Adione and Adiol, as SHBG ligands with affinity lower than T, nevertheless were capable to occupy some binding sites for T, if their output by adrenal-derived androgen cascade reached abundant values, leaving the latter free and correspondingly more active (Yoldemir et al 2020).…”

Section: Discussionmentioning

confidence: 99%

“…Density (Hu) of bone tissue of the maxillary and frontal sinuses in women with low DHEAS Values of the density (Hu) of bone tissue of the maxillary and frontal sinuses in the control group of women Correlation between density of the lower wall of Maxillary sinus and DHEAS and executive function, which usually undergoes deterioration during MT(Yoldemir et al 2020). Howerver, attempts to use DHEA supplements proved to be of no benefit in deterring cognitive loss.…”

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confidence: 99%

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Relationship between bone density of paranasal sinuses and adrenal steroids pattern in women during menopausal transition

Gargin

Muryzina

Shcherbina

et al. 2020

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The course of menopause transition (MT) is associated with peculiarities of alterations occurring in a woman’s body, in particular, in the structure of bone tissue. Considering that bones of the paranasal sinuses (BPNSs) play a natural defense role against the spread of dental infection, their structure is important in dentistry. However, no information was found pertaining to changes of BPNSs during MT – a time when dental maladies increase in many women.The aim of our study was to collate density of BPNSs with status of adrenal steroids in women during MT, since the pattern of their changes determines the course of MT.Cross-sectional associations were examined between bone density of PNSs assessed by Spiral Computed Tomography and Serum content of testosterone (T), sex hormone binding globulin (SHBG), free androgen index (FAI), insulin, dehydroepiandrosterone sulfate (DHEAS), Adione, and Adiol in 113 women of perimenopausal age (age range from 45 to 55 years) who had already experienced premenopausal menstrual decline (amenorrhea less than 2 years).Strong positive (r = 0.73) correlation between minimal bone density of maxillary sinus in women with level of DHEAS was detected. It is important to note, that the correlation between minimal density of the lower wall of frontal sinus is a weak positive (0.3). Therefore, it can be suggested that bone tissue of the maxillary sinus is more sensitive to changes in DHEAS.The study showed that the level of male steroids, in particular DHEAS, affected the state of bone tissue in participants older than 50 years of age.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Relationship between bone density of paranasal sinuses and adrenal steroids pattern in women during menopausal transition

Gargin

Muryzina

Shcherbina

et al. 2020

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“…Furthermore, androgen receptors are abundant in the vulvovaginal area 23 , and it has been suggested that they may be important for regulating genital arousal 24 . Despite all this favorable evidence, there are many reports showing that sexual function and dysfunction are unrelated to serum concentrations of gonadal hormones 25 . A simple explanation for the contradictory data may be that while a certain level of testosterone is needed for adequate sexual functioning in women, further increases in testosterone availability has no consequence.…”

Section: Women and Other Female Primates: Hormonesmentioning

confidence: 99%

Neuroendocrinology of sexual behavior

Ågmo

2022

Int J Impot Res

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One of the consequences of sexual behavior is reproduction. Thus, this behavior is essential for the survival of the species. However, the individual engaged in sexual behavior is rarely aware of its reproductive consequences. In fact, the human is probably the only species in which sexual acts may be performed with the explicit purpose of reproduction. Most human sexual activities as well as sex in other animals is performed with the aim of obtaining a state of positive affect. This makes sexual behavior important for wellbeing as well as for reproduction. It is not surprising, then, that sexual health has become an increasingly important issue, and that knowledge of the basic mechanisms controlling that behavior are urgently needed. The endocrine control of sexual behavior has been extensively studied, and although it is established that gonadal hormones are necessary, some controversy still exists concerning which hormone does what in which species. The brain areas necessary for sexual behavior have been determined in almost all vertebrates except the human. The media preoptic area is crucial in males of all non-human vertebrates, whereas the ventromedial nucleus of the hypothalamus is important in females. Modulatory functions have been ascribed to several other brain areas.

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“…Female sexual dysfunction (FSD) is defined as varying degrees of persistent or recurrent decline in sexual activity or sexual aversion, arousal disorder, inability to reach orgasm, and pain during sexual intercourse, as a single complaint or a group of complaints lasting more than six months. The prevalence of sexual dysfunction is higher in postmenopausal women and reaches 68 to 86.5%, depending on the study location (1). Most sexual problems in postmenopausal women occur in sexual desire, arousal, orgasm, and sexual activity.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Cinnamon and Vitex on Improving Sexual Function in Postmenopausal Women: A Triple-blind Randomized Clinical Trial

Koliji

Keshavarz

Mojab

et al. 2022

Jundishapur J Nat Pharm Prod

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Background: Sexual dysfunction is one of the most common problems following menopause. This study aimed to evaluate the effect of cinnamon and vitex on improving sexual function in postmenopausal women. Methods: This study was a randomized triple-blind clinical trial with a control group. Randomized sampling was used to allocate postmenopausal women into three cinnamon, vitex, and placebo groups of 35. A sexual function index was utilized before and two and three months after the intervention to assess sexual functioning. SPSS version 21 software was used for analysis. Results: The mean age was 54.45 ± 3.73 years. The overall sexual function score in the two cinnamon and vitex groups showed a statistically significant difference before and after treatment compared to the placebo group (P < 0.00). In the vitex group, sexual desire (P = 0.00) and arousal (P = 0.02) increased significantly compared to pre-intervention, and this significant increase was observed in the cinnamon group in lubricity (P = 0.00) and sexual satisfaction (P = 0.03). Conclusions: Cinnamon and vitex are effective medicinal herbs to alleviate sexual function.

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Sexual function through decades: association with androgens and cardiometabolic features

Cited by 5 publications

References 56 publications

Relationship between bone density of paranasal sinuses and adrenal steroids pattern in women during menopausal transition

Relationship between bone density of paranasal sinuses and adrenal steroids pattern in women during menopausal transition

Neuroendocrinology of sexual behavior

Comparison of Cinnamon and Vitex on Improving Sexual Function in Postmenopausal Women: A Triple-blind Randomized Clinical Trial

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