Sexual Function and Somatopsychic Reactions in Vulvectomy‐Operated Women and their Partners

Andreasson, Benny; Moth, Inge; Jensen, Søren Buus; Bock, Johannes E.

doi:10.3109/00016348609158221

Cited by 65 publications

(45 citation statements)

References 8 publications

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“…The main focus of the studies available on vulvar cancer and psychosocial well-being/quality of life is sexual functioning; this domain of quality of life appears to be significantly reduced in vulvar cancer patients [20][21][22][23][24]. Apart from our present study the only other study on vulvar cancer and global quality of life was performed by Janda et al They developed a vulvar cancer-specific quality of life subscale to accompany the Functional Assessment of Cancer-General (FACT-G) questionnaire.…”

Section: Discussionmentioning

confidence: 99%

A comparison of quality of life between vulvar cancer patients after sentinel lymph node procedure only and inguinofemoral lymphadenectomy

Oonk

Bock

et al. 2009

Gynecologic Oncology

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A comparison of quality of life between vulvar cancer patients after sentinel lymph node procedure only and inguinofemoral lymphadenectomy Oonk, M. H. M.; van Os, M. A.; de Bock, G. H.; de Hullu, J. A.; Ansink, A. C.; van der Zee, A. G. J. Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Objectives. The SLN-procedure has been introduced in vulvar cancer treatment to reduce morbidity and thereby improve quality of life. Aim of this study was to compare quality of life in vulvar cancer patients who were treated with a SLN-procedure only to those who underwent inguinofemoral lymphadenectomy. Moreover, it was evaluated what patients would advise relatives on the application of the SLN-procedure in light of possible false negative results.Methods. Patients who participated in the GROningen INternational Study on Sentinel nodes in Vulvar cancer (GROINSS-V) were invited to fill out three questionnaires: the EORTC QLQ-C30, a vulvar specific questionnaire and a questionnaire about the opinion of patients on new treatment options. Patients who only underwent SLN-procedure were compared to those who subsequently underwent inguinofemoral lymphadenectomy because of a positive SLN.Results. With a response rate of 85%, 35 patients after the SLN-procedure and 27 patients after inguinofemoral lymphadenectomy filled out the questionnaires. No difference in overall quality of life was observed between the two groups. The major difference was the increase in complaints of lymphedema of the legs after inguinofemoral lymphadenectomy. The majority of patients would advise the SLN-procedure to relatives. Patients after inguinofemoral lymphadenectomy were more reserved concerning the acceptable false negative rate of a new diagnostic procedure.Conclusions. Patients who underwent the SLN-procedure report less treatment related morbidity compared to those who underwent inguinofemoral lymphadenectomy. However, this did not influence overall quality of life. Furthermore, patients who underwent inguinofemoral lymphadenectomy are more reserved in advising the SLN-procedure to relatives.

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Section: Discussionmentioning

confidence: 99%

A comparison of quality of life between vulvar cancer patients after sentinel lymph node procedure only and inguinofemoral lymphadenectomy

Oonk

Bock

et al. 2009

Gynecologic Oncology

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“…For some women, sexuality has been shown to be adversely affected by the surgery, including a reported decreased frequency of sexual intercourse (Corney et al 1992), decreased desire and arousal (Andreasson et al 1986) and an increased prevalence of sexual dysfunction compared with healthy women (Andersen & Hacker 1983, Stellman et al 1984, Likes et al 2007, Hazewinkel et al 2012. It is also evident that for some women, intimacy and relationship status are more closely linked to sexual satisfaction than physical arousal (Weijmar Schultz et al 1986, Willibrord et al 1990.…”

Section: Introductionmentioning

confidence: 99%

Sexuality and body image following treatment for early‐stage vulvar cancer: a qualitative study

Barlow

Hacker

Hussain

et al. 2014

Journal of Advanced Nursing

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Findings from this study indicated that the majority of women experienced little to no long-term disruption to sexuality and body image following conservative treatment for early-stage vulvar cancer. Intimacy and relationship status were more closely linked to women's sexual satisfaction than physical arousal. Factors contributing to women experiencing negative emotions were radical vulvar excision, multiple vulvar procedures and/or the development of lymphoedema.

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“…10 Extensive surgery, such as vulvectomy, can lead to abnormal anatomy and thereby cause impairment of self-image and sexual function. 11 Recently, in a pilot study, van Seters demonstrated the positive effects of treatment with imiquimod, a topical immune response modifier. 12 It was observed that in 30% of cases treatment with imiquimod led to complete remission of the lesions, while another 60% of patients showed a partial remission.…”

mentioning

confidence: 99%

HPV related VIN: Highly proliferative and diminished responsiveness to extracellular signals

Santegoets

Seters

Helmerhorst

et al. 2007

Intl Journal of Cancer

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Vulvar intraepithelial neoplasia (VIN) is a premalignant disorder caused by human papillomaviruses. Basic knowledge about the molecular pathogenesis of VIN is sparse. Therefore, we have analyzed the gene expression profile of 9 VIN samples in comparison to 10 control samples by using genome wide Affymetrix Human U133A plus2 GeneChips. Results were validated by quantitative real-time RT-PCR analysis and immunostaining of a few representative genes (TACSTD1, CCNE2, AR and ESR1). Significance analysis of microarrays (SAM) showed that 1,497 genes were differentially expressed in VIN compared to controls. By analyzing the biological processes affected by the observed differences, we found that VIN appears to be a highly proliferative disease; many cyclins (CCNA, CCNB and CCNE) and almost all prereplication complex proteins are upregulated. Thereby, VIN does not seem to depend for its proliferation on paracrine or endocrine signals. Many receptors (for example ESR1 and AR) and ligands are downregulated. Furthermore, although VIN is not an invasive disease, the inhibition of expression of a marked number of cell-cell adhesion molecules seems to indicate development towards invasion. Upon reviewing apoptosis and angiogenesis, it was observed that these processes have not become significantly disregulated in VIN. In conclusion: although VIN is still a premalignant disease, it already displays several hallmarks of cancer. 1 Differentiated type VIN is mostly found in postmenopausal women and is associated with lichen sclerosus. In contrast, Usual type VIN (undifferentiated) is often diagnosed in premenopausal women and is strongly associated with sexually transmitted Human papilloma virus (HPV) infections. In this report, we will focus on HPVrelated, Usual Type VIN.During the last decade, VIN has been diagnosed with increasing frequency in relatively young women in western countries. This rise in incidence could be the result of a higher awareness and knowledge of VIN, but is more likely to be due to the overall increase in sexually transmitted diseases, and especially the rise in HPV infections. Around 40% of young, sexually active women are infected with high-risk HPV. 2 Fortunately most women are able to clear the infection, and less than 10% of infected women develop a persistent HPV infection which causes dysplasia of the lower genital tract and might cause VIN.3 Such a persistent infection with high-risk HPV (mostly HPV16, 18, 31 or 33) may trigger VIN to further develop into invasive vulvar cancer. What percentage of women with VIN eventually develop cancer is difficult to assess, because most patients with VIN will be treated effectively.van Seters et al. have reviewed data on 3,322 published patients with VIN and found 88 untreated patients, of whom 8 (9%) progressed to vulvar cancer. 4 A critical step in the defence against high-risk HPV is a good immune response. Accordingly, being immunocompromised is a risk factor for the development of VIN and subsequent vulvar cancer. For example, VIN is observed more often ...

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Sexual Function and Somatopsychic Reactions in Vulvectomy‐Operated Women and their Partners

Cited by 65 publications

References 8 publications

A comparison of quality of life between vulvar cancer patients after sentinel lymph node procedure only and inguinofemoral lymphadenectomy

A comparison of quality of life between vulvar cancer patients after sentinel lymph node procedure only and inguinofemoral lymphadenectomy

Sexuality and body image following treatment for early‐stage vulvar cancer: a qualitative study

HPV related VIN: Highly proliferative and diminished responsiveness to extracellular signals

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