Sexual Function and Clinical Features of Patients With Klinefelter's Syndrome With the Chief Complaint of Male Infertility

Yoshida, Atsumi; Miura, Kazukiyo; Nagao, Kōichi; Hara, Hiroshi; Ishii, Nobuhisa; Shirai, Masamitsu

doi:10.1016/s0022-5347(01)62468-6

Cited by 20 publications

(45 citation statements)

References 7 publications

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“…In contrast, little research has addressed sexual dysfunction in KS. It is generally reported that in KS low libido and erectile dysfunction are present (Paduch et al, 2008), however, only one study has investigated their characteristics (Yoshida et al, 1997). In that study, no difference was found in sexual functioning between KS subjects and infertile controls, with a frequency of sexual intercourse that was even higher in KS than in the control group.…”

Section: Discussionmentioning

confidence: 81%

“…In that study, no difference was found in sexual functioning between KS subjects and infertile controls, with a frequency of sexual intercourse that was even higher in KS than in the control group. However, the Yoshida et al (1997) study was not conducted in a population sample of subjects complaining of sexual dysfunction, but in subjects seeking medical care for infertility. The aim of this study was to systematically analyse the prevalence of KS in a consecutive series of male adult patients consulting for sexual problems and to investigate its specific correlates.…”

Section: Discussionmentioning

confidence: 99%

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Sexual dysfunction in subjects with Klinefelter’s syndrome

et al. 2010

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While the association of Klinefelter's Syndrome (KS) with infertility is well-known, very few investigations have evaluated the prevalence of sexual dysfunction in KS. The aim of the present study was to systematically analyse the prevalence of KS in a consecutive series of adult male patients consulting for sexual problems and to investigate its specific correlates. Among a consecutive series of 1386 men (mean age 48.9 +/- 12.7 years old), 23 (1.7%) subjects with KS were found. Patients with KS were younger and more often hypogonadal when compared with the rest of the sample. Among patients with KS, five (22.7%) subjects reported severe erectile dysfunction, 14 (60.9%) hypoactive sexual desire (HSD), two (9.5%) premature and two (9.5%) delayed ejaculation. Only the association between KS and HSD was confirmed after adjustment for age [HR = 3.2 (1.37-7.5)], however, when patients with KS were compared with age, smoking habit, and testosterone matched controls, even the association between KS with HSD disappeared. In comparison to matched hypogonadal controls, subjects with KS had lower levels of education, a higher frequency of cryptorchidism and poorer pubertal progression. In conclusion, our results indicate that sexual dysfunction present in KS is not specifically associated with the syndrome but is caused by the underlying hypogonadal state. Further studies are needed to evaluate the efficacy of testosterone substitution in ameliorating the hypoactive sexual desire often reported in subjects with KS.

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Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Sexual dysfunction in subjects with Klinefelter’s syndrome

et al. 2010

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“…These studies indicate that sexual dysfunction is a common feature of KS. Indeed, Yoshida et al (1997) compared the sexual features of 40 KS patients to 40 non-azospermic infertile 46,XY patients by using a non-validated questionnaire on sexual function (Questionnaire on Sexual Function: QSF). There was not a significant difference in the frequency of sexual function disturbances between the patients with KS and the control group.…”

Section: Non-obstructive Azoospermiamentioning

confidence: 99%

Male infertility: an obstacle to sexuality?

2016

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SUMMARYInteractions between infertility and sexuality are numerous and complex. Infertile men may suffer from sexual dysfunction (SD) when undergoing an assisted reproductive technology programme. We undertook a review both in French and English of the available data on male SD when being diagnosed with a fertility problem with a specific focus on azoospermic men. The review was performed over a 30-year time period using PubMed/Medline. The sexual concerns and needs of infertile/sterile men for whom potential parenting can be compromised were evaluated. When diagnosed with infertility, men usually go through a crisis that can have a deleterious effect on their sexuality with sometimes a feeling of sexual inadequacy. Infertile men will feel stigmatized because they are perceived as being deficient in a specific component of their masculinity. Hence, subsequent SD may occur that can impact the couple sexuality and the infertility management. However, little is known on how the announcement of azoospermia may affect male on a sexual and psychological point of view. The present review suggests that a global management through a healthcare network (biologist, andrologist, sexologist and psychologist) is required which will allow to consider infertility and its subsequent sexual disorders as a whole and not as dichotomized issues.

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“…It is usually reported that low libido and erectile dysfunction are present in Klinefelter patients, even if only a few studies have addressed this issue [Yoshida et al, 1997]. Corona et al [2009] studied the prevalence of Klinefelter among 1,386 consecutive patients consulting an Andrology Unit for erectile dysfunction; they found a prevalence of 1.7% (n = 23) of 47,XXY men who were younger than the rest of the sample (mean age 40.6 vs 51.7 years, respectively).…”

Section: Sexual Functionmentioning

confidence: 99%

Klinefelter’s Syndrome: A Clinical and Therapeutical Update

Forti

Corona

Vignozzi

et al. 2010

Sex Dev

105

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The prevalence of the Klinefelter’s syndrome, ranging between 1/500 and 1/1,000 in the general male population, rises up to 3–4% among infertile males and to 10–12% in azoospermic patients. Due to the paucity of symptoms, only 10% of Klinefelter patients are diagnosed prepubertally. The clinical spectrum of the phenotype of adult Klinefelter patients is very broad and ranges from clinically overt hypogonadism to normally virilized males. The diagnosis is usually made during the evaluation of couple infertility. The only nearly constant clinical feature is the reduced testicular volume and azoospermia or, in few cases, cryptozoospermia. Due to the variability of the phenotype and also to the fact that the main symptoms of the syndrome (androgen deficiency, infertility) are in the reproductive domain, approximately two thirds of Klinefelter patients are not diagnosed during their life. Low/normal testosterone and high levels of the luteinizing hormone (LH) suggest that all Klinefelter patients have overt or compensated hypogonadism which should be treated with testosterone, starting from the peri-pubertal age. Even if no medical treatment is possible for infertility, testicular sperm for assisted reproduction techniques can be obtained by multiple testicular biopsies in experienced centers in up to 50% of subjects. Although there are no predictors for successful sperm retrieval, the birth of 101 children with normal karyotype was reported in the last 15 years. Furthermore, the genetic risk to the offspring of Klinefelter patients has recently not been found to be greater than that of patients with nonobstructive azoospermia with normal karyotype.

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Sexual Function and Clinical Features of Patients With Klinefelter's Syndrome With the Chief Complaint of Male Infertility

Cited by 20 publications

References 7 publications

Sexual dysfunction in subjects with Klinefelter’s syndrome

Sexual dysfunction in subjects with Klinefelter’s syndrome

Male infertility: an obstacle to sexuality?

Klinefelter’s Syndrome: A Clinical and Therapeutical Update

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