Sexual Function after Partial Penectomy: A Prospectively Study From China

Chen, Hequn; Liu, Longfei; Chen, Minfeng; Chen, Zhi; Chen, Jinbo; Qi, Lin; Zu, Xiongbing

doi:10.1038/srep21862

Cited by 35 publications

(51 citation statements)

References 12 publications

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“…Penile cancer is a rare malignant tumor, which results in significant physiological and psychological effects on patients 1. Inguinal lymph nodes are the first site of metastasis in penile carcinoma 2.…”

Section: Introductionmentioning

confidence: 99%

<p>Predictors of inguinal lymph node metastasis in penile cancer patients: a meta-analysis of retrospective studies</p>

Hu¹,

Liu²,

Ren³

et al. 2019

CMAR

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Purpose Inguinal lymph node metastasis (LNM) is one of the most significant prognostic factors for patients with penile cancer. This study aimed to identify potential predictors of inguinal LNM. Patients and methods A comprehensive search of the PubMed, Embase, and Cochrane Library databases for studies that reported predictors of inguinal LNM in penile cancer was performed. Finally, we selected 42 eligible studies with 4,802 patients. Accumulative analyses of odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were performed. All analyses were performed by using Review Manager software version 5.3. Results Among the 4,802 patients, 1,706 (36%) were diagnosed with inguinal LNM. Predictors of LNM included two categories: tumor-associated biomarkers and invasive clinicopathologic characteristics. Biomarker-specific predictors: the program death ligand 1 (PD-L1) overexpression (OR=2.55, p =0.002), higher neutrophil-to-lymphocyte ratio (NLR) (OR=4.22, p =0.010), higher C-reactive protein (CRP) (OR=4.78, p <0.001), squamous cell carcinoma antigen (SCC-Ag) overexpression (OR=8.52, p <0.001), P53 protein overexpression (OR=3.57, p <0.001). Clinicopathological predictors: positive clinical lymph node (cN+) (OR=5.86, p <0.001), high-risk histopathological subtype (OR=14.63, p <0.001) and intermediate-risk subtype (OR=3.37, p <0.001), vertical growth pattern (OR=1.97, p =0.020), higher stage (AJCC: OR=3.66, p <0.001; UICC: OR=2.43, p <0.001), higher tumor grade (OR=3.37, p <0.001), tumor size (>3 cm) (OR=2.00, p =0.002), LVI (OR=3.37, p <0.001), invasion depth (>5 mm) (OR=2.58, p =0.002), nerve invasion (OR=2.84, p <0.001), corpora cavernosum invasion (OR=2.22, p <0.001), corpus spongiosum invasion (OR=1.73, p =0.002) and urethra invasion (OR=1.81, p =0.030). Conclusion Current meta-analysis conclusively identified valuable predictors of inguinal LNM for patients with penile cancer. However, high-quality studies are warranted to further validate our conclusions. The intrinsic link between these predictors needs to be further investigated to create an accurate mathematical prediction model for LNM.

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Section: Introductionmentioning

confidence: 99%

<p>Predictors of inguinal lymph node metastasis in penile cancer patients: a meta-analysis of retrospective studies</p>

Hu¹,

Liu²,

Ren³

et al. 2019

CMAR

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“…One of the largest cohort (n=36) of patients who underwent partial penectomy showed IIEF scores were 50% lower on erectile function when compared with healthy men with a mean IIEF score for erectile function of 11.30±9.32 (17). Recently, a prospective study with 43 patients reported statistically significant reduction of erectile function after partial penectomy where IIEF-15 score decreased from 26.70±3.07 to 17.81±10.66 (18). Age was negatively associated with erectile function (19).…”

Section: Discussionmentioning

confidence: 99%

“…The length of the penis shaft was performed with the penis in a flaccid state, measured in centimeters using a rigid ruler from the pubic bone to the end of the shaft. The possible scores for the IIEF-5 range from 5 to 25, a score of 1-5 is awarded to each of the 5 questions, and ED was classified into five categories based on the scores: severe (5-7), moderate (8)(9)(10)(11), mild to moderate (12)(13)(14)(15)(16), mild (17)(18)(19)(20)(21), and no ED (22)(23)(24)(25). The patients answered the questionnaire only once, at least 3 months after surgery (range from 3 to 6 months).…”

Section: Methodsmentioning

confidence: 99%

Erectile function after partial penectomy for penile cancer

et al. 2021

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Purpose: To evaluate the erectile function in patients who underwent partial penectomy and identify factors associated with penile functional status. Materials and Methods: We identified patients who underwent partial penectomy due to penile cancer between 2009 and 2014. Clinical and pathological characteristics included patient age at the time of diagnosis, obesity, hypertension, dyslipidemia, diabetes, smoking, metabolic syndrome, Eastern Cooperative Oncology Group (ECOG) status, penile shaft length, tumor size, primary tumor stage (pT), clinical nodal status, and local recurrence. Erectile function was assessed prospectively with the International Index of Erectile Function (IIEF-5) at least 3 months after partial penectomy. Results: A total of 81 patients met analysis criteria. At the diagnosis, the median age was 62 years (range from 30 to 88). Median follow-up was 17 months (IQR 7-36). Of total patients, 37 (45%) had T2 or higher disease. Clinically positive nodes were present in 16 (20%) patients and seven (8.6%) developed local recurrence. Fifty patients (62%) had erectile dysfunction (ED) after partial penectomy, 30% had moderate or severe erectile dysfunction scores. Patients with ED versus without ED were similar in baseline characteristics except for age, penile shaft length, and presence of inguinal adenopathy (p <0.05). Multivariate analysis using logistic regression confirmed that older patients, shorter penile shaft length, and clinically positive lymph node were significantly associated with ED. Conclusion: Partial penectomy due to penile cancer provides adequate local control of the disease, however, proper counselling is important especially in relation to ED consequences. Preservation of penile length yields to more optimal erectile recovery.

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“…Yu et al [36] surveyed the sexual health of 43 men undergoing partial penectomy using the International Index of Erectile Function (IIEF-15), which is a validated and reliable patient-reported questionnaire regarding sexual function that assesses a patient's erectile function, orgasmic function, sexual desire, intercourse satisfaction, and overall sexual satisfaction [37]. They noted significant reductions across all domains of the IIEF-15 postoperatively.…”

Section: Total and Partial Penectomymentioning

confidence: 99%

Penile Sparing Techniques For Penile Cancer

Fang

Ferguson

2020

Postgraduate Medicine

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Penile cancers are rare malignancies. Traditional surgical options, including partial and total penectomy, can dramatically affect a patient's quality of life and mental health. In select patients, penile sparing techniques (PST) have the potential to remove the primary tumor with comparable oncologic outcomes while maintaining penile length, sexual function, and urinary function. In this review, we aim to discuss the indications, advantages, and outcomes of the various PST currently available for men seeking an organ-preserving option for their penile cancer.

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Sexual Function after Partial Penectomy: A Prospectively Study From China

Cited by 35 publications

References 12 publications

<p>Predictors of inguinal lymph node metastasis in penile cancer patients: a meta-analysis of retrospective studies</p>

<p>Predictors of inguinal lymph node metastasis in penile cancer patients: a meta-analysis of retrospective studies</p>

Erectile function after partial penectomy for penile cancer

Penile Sparing Techniques For Penile Cancer

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