Sexual Experience Induces the Expression of Gastrin-Releasing Peptide and Oxytocin Receptors in the Spinal Ejaculation Generator in Rats

Oti, Takumi; Ueda, Ryota; Kumagai, Ryoko; Nagafuchi, Junta; Ito, Takashi; Sakamoto, Tatsuya; Kondo, Yasuhiko; Sakamoto, Hirotaka

doi:10.3390/ijms221910362

Cited by 3 publications

(1 citation statement)

References 37 publications

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“…In contrast, the mushroom spine density in the mPOA decreases and the expression of vgf, which encodes the neuropeptide precursor VGF in the mPOA, affects behavior (shortening mating latency) following mating and ejaculation experience in male rats 5 , 11 . We recently reported that the expression of gastrin-releasing peptide and oxytocin receptors is increased in the spinal ejaculation generator in the lumbosacral cord after the first mating experience with ejaculation in male rats 12 . Furthermore, the first mating experience also decreases neuronal activity in the center part of the mPOA, suggesting that the first mating experience reconstructs the neural network associated with male mating behavior 13 .…”

Section: Introductionmentioning

confidence: 98%

Mating experiences with the same partner enhanced mating activities of naïve male medaka fish

Daimon

Katsumura

Sakamoto

et al. 2022

Sci Rep

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Mating experience shapes male mating behavior across species, from insects, fish, and birds, to rodents. Here, we investigated the effect of multiple mating experiences on male mating behavior in “naïve” (defined as sexually inexperienced) male medaka fish. The latency to mate with the same female partner significantly decreased after the second encounter, whereas when the partner was changed, the latency to mate was not decreased. These findings suggest that mating experiences enhanced the mating activity of naïve males for the familiar female, but not for an unfamiliar female. In contrast, the mating experiences of “experienced” (defined as those having mated > 7 times) males with the same partner did not influence their latency to mate. Furthermore, we identified 10 highly and differentially expressed genes in the brains of the naïve males after the mating experience and revealed 3 genes that are required for a functional cascade of the thyroid hormone system. Together, these findings suggest that the mating experience of naïve male medaka fish influences their mating behaviors, with neural changes triggered by thyroid hormone activation in the brain.

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Section: Introductionmentioning

confidence: 98%

Mating experiences with the same partner enhanced mating activities of naïve male medaka fish

Daimon

Katsumura

Sakamoto

et al. 2022

Sci Rep

Self Cite

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A highly sensitive electrochemiluminescence sensor based on antimony tin oxide/TiO2 for detection of gastrin-releasing peptide (ProGRP)

Wu¹

2022

International Journal of Electrochemical Science

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Progastrin-releasing peptide (ProGRP) is a highly reliable, specific and sensitive tumor marker for small cell lung cancer, thus the measurement of ProGRP levels can realize the diagnosis, prediction of prognosis and treatment monitoring of small cell lung cancer. Aptamer can bind specifically to proteins or other substances with high selectivity and affinity, and it has more stable chemical properties than antibodies. In this work, an electrochemiluminescent aptamer sensor was constructed for ProGRP detection based on AgNPs composites. For the sensor, luminol was used as the luminol, hydrogen peroxide was used as the co-reaction reagent, and titanium dioxide and AgNPs were used to enhance the luminescence, which improved the luminescence intensity and sensitivity of the sensor. The linear detection range was 10 fg/mL-12 ng/mL with a detection limit of 1.3 fg/mL under optimal experimental conditions.

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Neurons for Ejaculation and Factors Affecting Ejaculation

Soni

Jeong

Jang

2022

Biology

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Ejaculation is a reflex and the last stage of intercourse in male mammals. It consists of two coordinated phases, emission and expulsion. The emission phase consists of secretions from the vas deferens, seminal vesicle, prostate, and Cowper’s gland. Once these contents reach the posterior urethra, movement of the contents becomes inevitable, followed by the expulsion phase. The urogenital organs are synchronized during this complete event. The L3–L4 (lumbar) segment, the spinal cord region responsible for ejaculation, nerve cell bodies, also called lumbar spinothalamic (LSt) cells, which are denoted as spinal ejaculation generators or lumbar spinothalamic cells [Lst]. Lst cells activation causes ejaculation. These Lst cells coordinate with [autonomic] parasympathetic and sympathetic assistance in ejaculation. The presence of a spinal ejaculatory generator has recently been confirmed in humans. Different types of ejaculatory dysfunction in humans include premature ejaculation (PE), retrograde ejaculation (RE), delayed ejaculation (DE), and anejaculation (AE). The most common form of ejaculatory dysfunction studied is premature ejaculation. The least common forms of ejaculation studied are delayed ejaculation and anejaculation. Despite the confirmation of Lst in humans, there is insufficient research on animals mimicking human ejaculatory dysfunction.

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Sexual Experience Induces the Expression of Gastrin-Releasing Peptide and Oxytocin Receptors in the Spinal Ejaculation Generator in Rats

Cited by 3 publications

References 37 publications

Mating experiences with the same partner enhanced mating activities of naïve male medaka fish

Mating experiences with the same partner enhanced mating activities of naïve male medaka fish

A highly sensitive electrochemiluminescence sensor based on antimony tin oxide/TiO2 for detection of gastrin-releasing peptide (ProGRP)

Neurons for Ejaculation and Factors Affecting Ejaculation

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