Sexual experience increases nitric oxide synthase in the medial preoptic area of male rats.

Domínguez, Juan M.; Brann, Jessica H.; Gil, Mario; Hull, Elaine M.

doi:10.1037/0735-7044.120.6.1389

Cited by 40 publications

(26 citation statements)

References 45 publications

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“…The preoptic area of gars houses a remarkable population of nitrergic cells distinct from the TH-ir, ChAT-ir, and CB-ir populations also observed in this region. The presence of nitrergic cells in the preoptic area is a highly conserved feature observed in all anamniotes studied (Table 2), whereas it is a more variable feature in amniotes, being present in birds [Brüning, 1993;Cozzi et al, 1997;Atoji et al, 2001] and some species of reptiles and mammals [Hadeishi and Wood, 1996;Domínguez et al, 2006;Nutsch et al, 2014], where the role of NO in sexual behavior has been demonstrated [Nutsch et al, 2014]. It should be noted that gene expression data have highlighted that the preoptic area does not belong to the hypothalamus but it is part of the subpallial telencephalic territory [see Moreno and González, 2011;Domínguez et al, 2015] that is topologically adjacent to the dorsal hypothalamic territory, and similar observations have been obtained for gars [González et al, 2014].…”

Section: Forebrainmentioning

confidence: 99%

Pattern of Nitrergic Neuronal System Organization in the Brain of Two Holostean Fishes (Actinopterygii: Ginglymodi)

et al. 2017

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The study of the nitrergic system, formed by the networks of neurons containing the enzyme nitric oxide synthase (NOS), has been extremely useful in unraveling neuroanatomical features of the organization of the central nervous system of vertebrates. Thus, data are available for representatives of most vertebrate classes and, in particular, several studies have detailed the organization of this system in teleosts. In contrast, no information is available regarding this neurotransmission system in the brains of holosteans, an early diverged and poorly understood group of actinopterygian fishes, currently considered a sister group of teleosts that contains only 8 species. The present study provides the first detailed information on the distribution of nitrergic cell bodies and fibers in 2 holostean species of the genus Lepisosteus, the spotted gar L. oculatus and the Florida gar L. platyrhincus. NOS immunohistochemistry and the NADPH diaphorase (NADPH-d) histochemical reaction were used, and both techniques yielded identical results, with the exception of the primary olfactory and terminal nerve fibers, which only labeled for NADPH-d exclusively in L. oculatus. Double immunohistochemistry was conducted for the simultaneous detection of NOS with tyrosine hydroxylase, choline acetyltransferase, calbindin, calretinin, and serotonin to accurately establish the localization of the nitrergic neurons and fibers in the brain of holosteans, the neuroanatomy of which has been mostly neglected, and to assess possible interactions between these neuroactive substances. Distinct groups of nitrergic cells were located in subpallial areas, the basal hypothalamus, posterior tubercle, optic tectum and mesencephalic tegmentum, reticular formation, solitary tract nucleus, spinal cord, and amacrine cells in the retina. In addition, low numbers of nitrergic cells were observed in the pallium, suprachiasmatic nucleus, prethalamic and thalamic areas, torus lateralis and torus semicircularis, cerebellar and laterodorsal tegmental nuclei, and the ventral octavolateral area. Comparison of these results with those from other classes of vertebrates, and including a segmental analysis to correlate cell populations, reveals that the pattern of the nitrergic system in holosteans is very close to that in ancestral actinopterygian fishes and highlights conserved and derived traits.

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Section: Forebrainmentioning

confidence: 99%

Pattern of Nitrergic Neuronal System Organization in the Brain of Two Holostean Fishes (Actinopterygii: Ginglymodi)

et al. 2017

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“…Increased sensitivity to testosterone via MPOA AR might play a role in nitric oxide synthase-mediated local dopamine release. Indeed, levels of nitric oxide synthase in the MPOA have been shown to be elevated in sexually experienced male rats (Dominguez et al, 2006), indicating that this circuit is also sensitive to sexual experience and potentially pointing to an interaction between gonadal steroids and dopamine within the MPOA. Elucidating these interactions would provide insight into the mechanisms of plasticity in the male brain that are recruited during reproductive experience.…”

Section: Discussionmentioning

confidence: 99%

Sexual experience affects reproductive behavior and preoptic androgen receptors in male mice

Swaney

Dubose

Curley

et al. 2012

Hormones and Behavior

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Reproductive behavior in male rodents is made up of anticipatory and consummatory elements which are regulated in the brain by sensory systems, reward circuits and hormone signaling. Gonadal steroids play a key role in the regulation of male sexual behavior via steroid receptors in the hypothalamus and preoptic area. Typical patterns of male reproductive behavior have been characterized, however these are not fixed but are modulated by adult experience. We assessed the effects of repeated sexual experience on male reproductive behavior of C57BL/6 mice; including measures of olfactory investigation of females, mounting, intromission and ejaculation. The effects of sexual experience on the number of cells expressing either androgen receptor (AR) or estrogen receptor alpha (ERα) in the primary brain nuclei regulating male sexual behavior was also measured. Sexually experienced male mice engaged in less sniffing of females before initiating sexual behavior and exhibited shorter latencies to mount and intromit, increased frequency of intromission, and increased duration of intromission relative to mounting. No changes in numbers of ERα-positive cells were observed, however sexually experienced males had increased numbers of AR-positive cells in the medial preoptic area (MPOA); the primary regulatory nucleus for male sexual behavior. These results indicate that sexual experience results in a qualitative change in male reproductive behavior in mice that is associated with increased testosterone sensitivity in the MPOA and that this nucleus may play a key integrative role in mediating the effects of sexual experience on male behavior.

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“…Sexual experience increases nNOS activity in the MPOA in male rats (Dominguez et al 2006). Our previous study showed that sexually experienced rats treated with EGb 761 exhibited a significant increase in intromission and ejaculation frequency, but EGb 761 did not influence nNOS-IR cells in the MPOA (Yeh et al 2011b), suggesting that enhanced male copulatory performance in sexually experienced rats treated with EGb 761 may not be related to central nNOS activity in the MPOA.…”

Section: L6 S1mentioning

confidence: 97%

Noncontact erection is enhanced by Ginkgo biloba treatment in rats: role of neuronal NOS in the paraventricular nucleus and sacral spinal cord

Yeh¹,

Tsai

2012

Psychopharmacology

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Sexual experience increases nitric oxide synthase in the medial preoptic area of male rats.

Cited by 40 publications

References 45 publications

Pattern of Nitrergic Neuronal System Organization in the Brain of Two Holostean Fishes (Actinopterygii: Ginglymodi)

Pattern of Nitrergic Neuronal System Organization in the Brain of Two Holostean Fishes (Actinopterygii: Ginglymodi)

Sexual experience affects reproductive behavior and preoptic androgen receptors in male mice

Noncontact erection is enhanced by Ginkgo biloba treatment in rats: role of neuronal NOS in the paraventricular nucleus and sacral spinal cord

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