Sexual Effect of Platelet-to-Lymphocyte Ratio in Predicting Cardiovascular Mortality of Peritoneal Dialysis Patients

Sheng, Hui; Qiu, Yagui; Xia, Xi; Chen, Yi; Lin, Jianxiong; Yang, Xiao; Huang, Fengxian

doi:10.1155/2022/8760615

Cited by 4 publications

(3 citation statements)

References 38 publications

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“…Huang et al reported the effect of different gender on PLR ratio to predict cardiovascular mortality of peritoneal dialysis (PD) patients. For female PD patients, high PLR ratio was related to worse prognosis due to higher level of estrogen and low levels of serum iron 33 . Our study did not find the same effect of gender in our TBI patients.…”

Section: Discussionmentioning

confidence: 97%

Platelet-to-lymphocyte ratio predicts short-term mortality in patients with moderate to severe traumatic brain injury

Deng

2022

Sci Rep

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An easily accessible biomarker with good diagnostic power for patients with traumatic brain injury (TBI) was needed to predict the short-term mortality. Studies have shown that platelet-to-lymphocyte ratio (PLR) is a biomarker for patients with tumor. This study aimed to identify the relationship between PLR and short-term mortality in patients with moderate to severe TBI. This is a retrospective cohort study. We selected patients with moderate to severe TBI who were admitted to the emergency department of The First Affiliated Hospital of Zhengzhou University. Biomarkers were collected within 24 h after admission. To investigate their relationship with short-term mortality, Cox proportional hazards regression and ROC curve analysis were performed. A total number of 170 patients was included. 47 (27.6%) patients had died and 123 (72.4%) patients were survived by the end of the study. Patients with different Rotterdam CT score (HR = 1.571, 95%CI 1.232–2.002, p < 0.001) or PLR levels (HR = 1.523, 95%CI 1.110–2.090, p = 0.009) had significant different mortality rates. The AUC curve analysis showed that the AUC of Rotterdam CT score and PLR groups were 0.729 (95%CI 0.638–0.821, p < 0.001) and 0.711 (95%CI 0.618–0.803 p < 0.001), respectively. PLR level is an independent biomarker with great diagnostic power for short-term mortality in patients with moderate to severe brain injury.

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Section: Discussionmentioning

confidence: 97%

Platelet-to-lymphocyte ratio predicts short-term mortality in patients with moderate to severe traumatic brain injury

Deng

2022

Sci Rep

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“…Previous studies have indicated that there have been similar biological biomarkers verified to predict mortality in PD patients, such as NLR, PLR, MLR and LHR. [36][37][38][39] In the current study, we compare the predictive values of NPAR with NLR, PLR, MLR and LHR. Our findings revealed that NPAR had a higher AUC value compared with other four biomarkers and showed superior and more reliable predictive efficiency.…”

Section: Dovepressmentioning

confidence: 99%

Neutrophil Percentage-to-Albumin Ratio and Risk of Mortality in Patients on Peritoneal Dialysis

Yu,

Zhong,

Yang

et al. 2023

JIR

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Background Neutrophil percentage-to-albumin ratio (NPAR), a new inflammatory marker, has been shown to be associated with poor prognosis in patients with cardiovascular disease. However, limited evidence is available for its role in peritoneal dialysis (PD) patients. Our study aimed at investigating the prognostic value of NPAR for mortality in PD patients. Patients and Methods This was a single center retrospective cohort study. A total of 1966 PD patients were enrolled in our study from January 2006 to December 2016 and were followed up until December 2021. Patients were stratified into tertiles according to baseline NPAR levels. The associations between NPAR levels with all-cause and cardiovascular mortality were estimated using Cox proportional hazards models. Receiver operating characteristic (ROC) analysis was performed to compare the mortality predictive values of NPAR and other known biomarkers, such as NLR (neutrophil-to-lymphocyte ratio), PLR (platelet-to-lymphocyte ratio), LHR (low-density lipoprotein cholesterol-to-high-density lipoprotein cholesterol ratio) and MLR (monocyte-to-lymphocyte ratio). Results During a median follow-up of 48.1 months, 503 (25.6%) patients died, in which cardiovascular disease (CVD) death dominated 50.3%. Multivariate Cox regression analysis revealed that the highest NPAR tertile was significantly associated with a higher risk of all-cause and cardiovascular mortality (HR 1.51, 95% CI 1.14–1.98; HR 1.57, 95% CI 1.07–2.31; respectively) compared with tertile 1. The AUC values of NPAR were 0.62 (95% CI 0.60–0.65, P < 0.001) for all-cause mortality and 0.61 (95% CI 0.57–0.65, P < 0.001) for cardiovascular mortality. Conclusion Our study showed that higher NPAR levels were independently associated with increased risk of all-cause and cardiovascular mortality in PD patients. Notably, our results demonstrated that NPAR exhibited superior predictive value for mortality compared to NLR, PLR, MLR, and LHR.

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“…In dialysis and non-dialysis patients with chronic kidney disease(CKD), PLR has been reported to be associated with inflammation [ 16 ]. And some studies also have shown that PLR is associated with all-cause mortality and the prognosis of cardiovascular events in patients with CKD [ 16 – 19 ]. To date, no studies have revealed the association between PLR and PDRP in PD patients.…”

Section: Introductionmentioning

confidence: 99%

Platelet-to-lymphocyte ratio and the first occurrence of peritonitis in peritoneal dialysis patients

Zheng

Zhang

et al. 2022

BMC Nephrol

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Background Platelet-to-lymphocyte ratio (PLR) has been used as a potential biomarker of inflammation-related diseases, but its role in the peritoneal dialysis-related peritonitis (PDRP) is still uncertain. This study was aimed to investigate the association between PLR and the new-onset PDRP in peritoneal dialysis (PD) patients. Methods In this multicenter retrospective study, 1378 PD Chinese PD patients were recruited from four centers, who were divided into the high PLR group (HPG) and the low PLR group (LPG) according to the cutoff value of PLR. The correlation between PLR and the new-onset PDRP was assessed using the Cox regression model analysis. Results During follow-up, 121 new-onset PDRP events were recorded. Kaplan–Meier survival curve showed a higher risk of new-onset PDRP in the HPG (log-rank test, P < 0.001). After adjusting for confounding factors, the Cox regression model showed the risk of new-onset PDRP was higher in the HPG than that in the LPG (HR 1.689, 95%CI 1.096–2.602, P = 0.017). Competitive risk model analysis showed that significant differences still existed between the two PLR groups in the presence of other competitive events (P < 0.001). Conclusion PLR is independently associated with the new-onset PDRP in PD patients.

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Sexual Effect of Platelet-to-Lymphocyte Ratio in Predicting Cardiovascular Mortality of Peritoneal Dialysis Patients

Cited by 4 publications

References 38 publications

Platelet-to-lymphocyte ratio predicts short-term mortality in patients with moderate to severe traumatic brain injury

Platelet-to-lymphocyte ratio predicts short-term mortality in patients with moderate to severe traumatic brain injury

Neutrophil Percentage-to-Albumin Ratio and Risk of Mortality in Patients on Peritoneal Dialysis

Platelet-to-lymphocyte ratio and the first occurrence of peritonitis in peritoneal dialysis patients

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