Sexual Dysfunction Related to Psychotropic Drugs: A Critical Review - Part I: Antidepressants

Torre, Antonio La; Giupponi, Giancarlo; Duffy, Dearbhla; Conca, Andreas

doi:10.1055/s-0033-1345205

Cited by 72 publications

(56 citation statements)

References 116 publications

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“…In the assessment, direct questions instead of specific questionnaires decease correct diagnosis of drug-induced sexual dysfunction [3].…”

Section: Discussionmentioning

confidence: 99%

“…Sexual behaviour is controlled by the following brain structures: the medial forebrain bundle, the medial preoptic-anterior region of the hypothalamus and its related limbic-hippocampal structures, and the ventral tegmentum of the midbrain [3]. Desire, arousal, and orgasm are the three phases of the human sexual response.…”

Section: Literature Review Psychotropic Use and Sexual Dysfunction-pamentioning

confidence: 99%

“…Commonest sexual dysfunction is delayed ejaculation. Others include problems in orgasm, desire, and/or arousal; erectile dysfunction and less vaginal lubrication included [3].…”

Section: Neurotransmittersmentioning

confidence: 99%

“…Prevalence rate varies from ten per cent to 80% as far as antidepressant-induced sexual dysfunction is concerned, especially SSRIs. Some sexual dysfunction is caused by all antidepressants [3].…”

Section: Neurotransmittersmentioning

confidence: 99%

“…There are various psychometric rating scales, [3] e.g. Arizona Sexual Experience Scale (ASEX), Changes in Sexual Functioning Questionnaire (CSFQ), Derogatis Sexual Function Inventory (DSFI), Psychotropic-Related Sexual Dysfunction Questionnaire (PRSexDQ), Rush Sexual Inventory (RSI), Sex Effect Scale (Sex FX), Udvalg for Kliniske undersøgelser (UKU).…”

Section: Neurotransmittersmentioning

confidence: 99%

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Psychotropic Use and Sexual Dysfunction: Is There a Practical Solution?

Das¹

2017

J Trauma Treat

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The psychotropic medications that we commonly use in our day-to-day life clinical practice are comparable to the players of a football team. If benzodiazepine, whether it is lorazepam, clonazepam, or clobazam is our goalkeeper, then in a 4-3-3 formation we have four strong defenders in the form of fluoxetine, sertraline, paroxetine, and escitalopram. If Lithium is our central defensive midfielder, then the two wingers of our team are valproate and carbamazepine. With quetiapine as our central attacking midfielder, the two lethal strikers at our disposal are risperidone and olanzapine. Thus, we have a good team of 11 players. And we are ready for our game against psychiatric disorders. But, like injury being commonplace for players in a football field, also we have to deal with adverse effects in our practice; sexual dysfunction is one of them. From a category-based classification of psychotropic medications, we are moving towards a mechanism-based one. Talking about mechanisms, prolactin raising 'antipsychotic' is responsible for sexual dysfunction associated with psychotropic use. 'Antidepressant' with higher serotonergic property can also cause sexual dysfunction. There are practical solutions to the problem. Prolactin sparing antipsychotic has less potential to cause sexual dysfunction. Among antidepressants, mirtazapine and bupropion are useful agents. At times, treatment with molecules like sildenafil is necessary. When we combine with this pharmacological approach that of psychosocial intervention, we arrive at a synergic reaction. The ultimate goal is to tailor make our treatment, or in other words 'personalised medicine in psychiatry'.

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“…In the assessment, direct questions instead of specific questionnaires decease correct diagnosis of drug-induced sexual dysfunction [3].…”

Section: Discussionmentioning

confidence: 99%

Section: Literature Review Psychotropic Use and Sexual Dysfunction-pamentioning

confidence: 99%

“…Commonest sexual dysfunction is delayed ejaculation. Others include problems in orgasm, desire, and/or arousal; erectile dysfunction and less vaginal lubrication included [3].…”

Section: Neurotransmittersmentioning

confidence: 99%

Section: Neurotransmittersmentioning

confidence: 99%

Section: Neurotransmittersmentioning

confidence: 99%

See 3 more Smart Citations