Sexual dysfunction in young adult survivors of childhood cancer – A population-based study

Hovén, Emma; Fagerkvist, Kristina; Jahnukainen, Kirsi; Ljungman, Lisa; Lähteenmäki, Päivi; Axelssön, Ove; Lampic, Claudia; Wettergren, Lena

doi:10.1016/j.ejca.2021.06.014

Cited by 25 publications

(57 citation statements)

References 36 publications

(60 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar to a recent study from Sweden including adult childhood cancer survivors 35 and findings in healthy adolescents in the general population of Switzerland, 29 we found that female survivors were more likely to have a more negative body image than male survivors. This confirms the extensive literature on sex differences in body image, indicating that females are more likely to negatively self‐evaluate their appearance and report higher levels of body image dissatisfaction than men 14 .…”

Section: Discussionsupporting

confidence: 90%

“…This is in line with a study from the Netherlands including adult survivors 9 and a previous systematic review including quantitative and qualitative studies and patients on active treatment. 13 Similar to a recent study from Sweden including adult childhood cancer survivors 35 and findings in healthy adolescents in the general population of Switzerland, 29 we found that female survivors were more likely to have a more negative body image than male survivors.…”

Section: Discussionsupporting

confidence: 87%

See 1 more Smart Citation

Body image in adolescent survivors of childhood cancer: The role of chronic health conditions

Belle

Sláma

Schindera

et al. 2022

Pediatric Blood & Cancer

View full text Add to dashboard Cite

Background Cancer and its treatment may impair the body image of childhood cancer survivors during adolescence. We compared the body image between adolescent cancer survivors and their siblings, and determined whether survivors’ body image is associated with socio‐demographic characteristics, clinical characteristics and chronic health conditions. Procedure As part of the nationwide Swiss Childhood Cancer Survivor Study, we sent questionnaires to adolescents (aged 16–19 years), who survived >5 years after having been diagnosed with childhood cancer between 1989 and 2010. Siblings received the same questionnaire. We assessed the level of agreement with three body image statements referring to body satisfaction and preferences for changes. Chronic health conditions were classified into cardiovascular, pulmonary, endocrine, musculoskeletal, renal/digestive, neurological and hearing or vision impairment. We used ordered logistic regression models to identify determinants of a more negative body image. Results Our study included 504 survivors (48% female) with a median age at study of 17.7 years (interquartile range: 16.8–18.6) and 136 siblings. Survivors and siblings reported overall comparable levels of agreement with body image statements (all p > .05). Female survivors (all odds ratio [ORs] ≥1.7), survivors treated with haematopoietic stem cell transplantation (HSCT; all ORs ≥2.2), and survivors with ≥2 chronic health conditions (all ORs ≥1.4) reported a more negative body image. This was particularly pronounced for survivors suffering from musculoskeletal or endocrine conditions. Conclusion Female survivors, survivors treated with HSCT or with chronic health conditions are at risk of body image concerns during adolescence. Increased awareness among clinicians and targeted psychosocial support could mitigate such concerns.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 87%

Body image in adolescent survivors of childhood cancer: The role of chronic health conditions

Belle

Sláma

Schindera

et al. 2022

Pediatric Blood & Cancer

View full text Add to dashboard Cite

show abstract

“…19 Evidence from other studies including adolescent long-term childhood cancer survivors is limited by lack of population-based sampling approaches and restrictions to certain cancer types. [35][36][37] Similar to a recent study from Sweden including adult childhood cancer survivors 20 and findings in healthy adolescents in the general population of Switzerland, 28 we found that female survivors were more likely to have a more negative body image than male survivors. This confirms the extensive literature on sex differences in body image indicating that females are more likely to negatively self-evaluate their appearance and report higher levels of body image dissatisfaction than men.…”

Section: Discussionsupporting

confidence: 89%

“…[15][16][17][18] However, a systematic review from 2009 concluded that there is no consistent evidence regarding differences in body image between children and adolescents with cancer and healthy controls. 19 A recent study from Sweden indicated higher body image disturbance in adult women who survived childhood cancer compared to the cancer-free women 20 while another study from the Netherlands found no differences. 9 However, evidence from studies including adolescent childhood cancer survivors is sparse and it remains unclear how chronic health conditions affect the body image of long-term survivors.…”

Section: Introductionmentioning

confidence: 98%

Body image in adolescent survivors of childhood cancer: the role of chronic health conditions

Belle

Sláma

Schindera

et al. 2022

Preprint

View full text Add to dashboard Cite

Background: Cancer diagnosis and its treatment may impair the long-term body image of childhood cancer survivors. This may be particularly relevant in adolescence, a critical period of psycho-social development. We compared the body image between adolescent cancer survivors and their siblings, and determined whether survivors’ body image is associated with socio-demographic characteristics, clinical characteristics, and health conditions. Procedure: As part of the nationwide Swiss Childhood Cancer Survivor Study, we sent questionnaires to adolescents (aged 16-19 years), who survived >5 years after having been diagnosed with childhood cancer between 1976-2010. Siblings received the same questionnaire. We assessed the level of agreement with three body image statements referring to body satisfaction and preferences for changes. Chronic health conditions were classified into cardiovascular, pulmonary, endocrine, musculoskeletal, renal/ digestive, neurological, and hearing or vision impairment. We used ordered logistic regression models to identify determinants of a more negative body image. Results: Our study included 504 survivors (48% female) with a median age at study of 17.7 years (IQR 16.8-18.6) and 136 siblings. Survivors and siblings reported overall comparable levels of the three body image statements (all p>0.05). Female survivors (all ORs ≥ 1.7), survivors treated with haematopoietic stem cell transplantation (all ORs ≥ 2.2), and survivors with ≥ 2 chronic health conditions (all ORs ≥ 1.4) reported a more negative body image. This was particularly pronounced for survivors suffering from musculoskeletal or endocrine conditions. Conclusion: Clinicians should address body image concerns in adolescent survivors with chronic conditions and offer psycho-social support if necessary.

show abstract

“…This observation reflects the multitude of bio‐psycho‐social factors associated with partnering and having children. The importance of being able to form long‐lasting relationships for the chance of pregnancy is clinically significant considering that previous reports have found cancer survivors to be less likely to partner in adulthood 11,19 …”

Section: Discussionmentioning

confidence: 99%

Premature ovarian insufficiency and chance of pregnancy after childhood cancer: A population‐based study (the Fex‐Can study)

Haavisto

Wettergren

Lampic

et al. 2023

Intl Journal of Cancer

Self Cite

View full text Add to dashboard Cite

Endocrine complications are a common late effect after childhood cancer. Our study assessed the prevalence and predictors of premature ovarian insufficiency (POI) and prospects of pregnancy in young female survivors. This nationwide study combined registry and survey data for female childhood cancer survivors aged 19 to 40 years, identified through the National Quality Registry for Childhood Cancer in Sweden. Of 1989 approached young women, 1333 (67%) participated by completing a survey.Median age at diagnosis 1981 to 2017 was 6 (range 0-17) and at study 28 (19-40) years. There were two indicators of POI, induced puberty reported in 5.3% and estrogen replacement therapy (ERT) in 9.3% at assessment. In separate logistic regression analyses (P < .001), induced puberty and ERT were significantly predicted by hematopoietic stem cell transplantation (HSCT), abdominal irradiation, central nervous system irradiation and chemotherapy. ERT was also associated with older age at diagnosis. Of the 626 women (48% of responders) who had tried to become pregnant, 25% had undergone fertility investigations and 72% reported having a biological child. Treatment with HSCT was associated with 5.4 times the odds of needing fertility investigations (P < .001). Having a biological child was associated with non-HSCT treatment, but also with ever having had a partner and older age at the time of study Abbreviations: AOF, acute ovarian failure; CNS, central nervous system; ERT, estrogen replacement therapy; HSCT, hematopoietic stem cell transplantation; POI, premature ovarian insufficiency; TBI, total body irradiation.

show abstract

Sexual dysfunction in young adult survivors of childhood cancer – A population-based study

Cited by 25 publications

References 36 publications

Body image in adolescent survivors of childhood cancer: The role of chronic health conditions

Body image in adolescent survivors of childhood cancer: The role of chronic health conditions

Body image in adolescent survivors of childhood cancer: the role of chronic health conditions

Premature ovarian insufficiency and chance of pregnancy after childhood cancer: A population‐based study (the Fex‐Can study)

Contact Info

Product

Resources

About