Sexual dysfunction in women with Parkinson's disease

Varanda, Sara; Silva, Joana R.; Costa, Ana Sofia; Carvalho, Cristiana Amorim de; Alves, José Nuno; Rodrigues, Margarida; Carneiro, Gisela

doi:10.1002/mds.26739

Cited by 31 publications

(23 citation statements)

References 58 publications

(68 reference statements)

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“…The underlying pathology is hypothalamic dysfunction via altered dopamine-oxytocin pathways, which normally promote libido. 38 Varanda et al 39 described sexual dysfunction in women with PD and reported it at 86.9%. Interestingly Hu et al 40 conducted a study on Chinese male patients and reported sexual dysfunction was found in 41.4% of their patients.…”

Section: Discussionmentioning

confidence: 99%

Frequency of non-motor symptoms in Parkinson’s disease presenting to tertiary care centre in Pakistan: an observational, cross-sectional study

et al. 2018

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ObjectiveTo determine the frequency of non-motor symptoms (NMS) in patients of Parkinson’s disease (PD) presenting to a movement disorder clinic at a tertiary care centre in Pakistan, and how frequency of NMS is different in male and female patients.Study designObservational, cross-sectional study.SettingTertiary care centre.ParticipantsOut of 102 patients, 85 were included. Inclusion criteria were patients with PD diagnosed according to the UK Parkinson’s Disease Society Brain Bank Clinical Diagnostic Criteria, age ≥18 years, able to give consent and have no difficulty in answering questions. Exclusion criteria were diseases that resemble PD, stroke, dementia, patients unable to provide information and history of antipsychotic use.ResultsThe NMSQuest revealed a mean of nearly seven different NMS per patient. Autonomic problems such as constipation (56%) and nocturia (49%) were the most common NMS, while urinary urgency was reported by 35% of patients. Low mood and feeling sad were reported by 47%, whereas feeling anxious/panicky was reported by 36%. Problem with memory was reported by 45% of patients. Feeling of light-headedness and dizziness was reported by 40% of patients. Problems with sexual relationship were reported by 30% of patients. The most common sleep problem was difficulty falling sleep (29%). Pain not related to the musculoskeletal system was reported by 30% of patients. Loss or change in the ability to taste or smell was reported by 29% of patients. The rest of NMS were less than 25% in frequency. Feeling sad or blue, feeling light-headed/dizzy, unexplained pain, unpleasant sensations in the legs, difficulty in swallowing and faecal incontinence were more common in female participants, while problems with sex were more common in male participants.ConclusionNMS are quite prevalent in PD in our population. Certain NMS are more common in women as compared with men. There is a need for a large-scale study to look for the association of different NMS with sex.

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Section: Discussionmentioning

confidence: 99%

Frequency of non-motor symptoms in Parkinson’s disease presenting to tertiary care centre in Pakistan: an observational, cross-sectional study

et al. 2018

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“…Erectile dysfunction is present in up to 97% of men diagnosed with MSA, and it is the initial symptom in 48% of male patients, preceding motor symptoms for as long as a decade (30, 59, 64). Female sexual dysfunction has been less studied in α-synucleinopathies, but a higher prevalence of this disorder has been found in female PD patients than in age-matched controls, and it is related to older age and a higher severity of depressive symptoms (67).…”

Section: Specific Dysautonomic Symptoms In α-Synucleinopathiesmentioning

confidence: 99%

Autonomic Dysfunction in α-Synucleinopathies

et al. 2019

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The α-synucleinopathies are a group of neurodegenerative diseases characterized by abnormal accumulation of insoluble α-synuclein in neurons and glial cells, comprising Parkinson's disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy (MSA). Although varying in prevalence, symptom patterns, and severity among disorders, all α-synucleinopathies have in common autonomic nervous system dysfunctions, which reduce quality of life. Frequent symptoms among α-synucleinopathies include constipation, urinary and sexual dysfunction, and cardiovascular autonomic symptoms such as orthostatic hypotension, supine hypertension, and reduced heart rate variability. Symptoms due to autonomic dysfunction can appear before motor symptom onset, particularly in MSA and PD, hence, detection and quantitative analysis of these symptoms can enable early diagnosis and initiation of treatment, as well as identification of at-risk populations. While patients with PD, DLB, and MSA show both central and peripheral nervous system involvement of α-synuclein pathology, pure autonomic failure (PAF) is a condition characterized by generalized dysregulation of the autonomic nervous system with neuronal cytoplasmic α-synuclein inclusions in the peripheral autonomic small nerve fibers. Patients with PAF often present with orthostatic hypotension, reduced heart rate variability, anhydrosis, erectile dysfunction, and constipation, without motor or cognitive impairment. These patients also have an increased risk of developing an α-synucleinopathy with central involvement, such as PD, DLB, or MSA in later life, possibly indicating a pathophysiological disease continuum. Pathophysiological aspects, as well as developments in diagnosing and treating dysautonomic symptoms in patients with α-synucleinopathies are discussed in this review.

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“…With a prevalence up to 79%, erectile dysfunction (ED) is the most common complaint in PD men [ 12 ]. In female PD patients SD is present in up to 87% [ 13 ]. Loss of libido is reported to be the most common SD and is 83% twice as prevalent than in the healthy population [ 12 , 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Sexual Dysfunctions in Parkinson’s Disease and Their Influence on Partnership—Data of the PRISM Study

et al. 2022

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Background: Sexual dysfunctions (SD) are common but underreported in Parkinson’s disease (PD) and have negative impacts on the quality of life (QoL) and partnership. Methods: We analyzed the data set from the PRISM study for demographics of SD and their influence on quality of life and partnership. Results: 449/861 (52.1%) PD patients reported SD, with male patients being affected more often and having a longer course of disease. The most common SD in men was erectile dysfunction (ED) (n = 152), while women’s most frequent complaints were orgasm dysfunction (n = 84) and reduced libido (n = 81). Hypersexual SDs were reported significantly more often by men. Spousal caregivers of patients reporting inability to relax and enjoy sex and reduced libido indicated a negative influence on the relationship in general. Negative effects on the sexual relationship were reported significantly more often for patients with ED, difficulties with sexual arousal, inability to relax and enjoy sex, and reduced libido. Hypersexual dysfunctions showed no effect on the relationship. Conclusion: SD is a common but underreported problem in the treatment of patients with PD. Due to the negative influence on the relationship and QoL of patients and caregivers, SD should be assessed routinely.

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Sexual dysfunction in women with Parkinson's disease

Cited by 31 publications

References 58 publications

Frequency of non-motor symptoms in Parkinson’s disease presenting to tertiary care centre in Pakistan: an observational, cross-sectional study

Frequency of non-motor symptoms in Parkinson’s disease presenting to tertiary care centre in Pakistan: an observational, cross-sectional study

Autonomic Dysfunction in α-Synucleinopathies

Sexual Dysfunctions in Parkinson’s Disease and Their Influence on Partnership—Data of the PRISM Study

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