Sexual Dysfunction in Women with Diabetic Kidney

Satta, Ersilia; Magno, Carlo; Galı̀, Alessandro; Inferrera, Antonino; Granese, Roberta; Aloisi, Carmela; Buemi, Michele; Bellinghieri, Guido; Santoro, Domenico

doi:10.1155/2014/346834

Cited by 12 publications

(6 citation statements)

References 29 publications

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“…Also, our patients with positive urinary microalbuminuria were more likely to have FSD. Similar ndings were reported in previous studies in patients with chronic kidney disease (33,34) .…”

Section: Discussionsupporting

confidence: 92%

Prevalence of Sexual Dysfunction in Women with Type 1, 2 Diabetes and Thyroid Disorder: A Cross-Sectional Study in Taif City, Saudi Arabia

Alshehri¹,

Thobaiti

Alqurashi

et al. 2020

Preprint

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Background: Women with diabetes mellitus or thyroid disorders are at risk of sexual dysfunction. This study aimed to estimate the prevalence of female sexual dysfunction (FSD) in women with diabetes and/or thyroid disorders and the impact of disease control on the ASEX score.Methods: A cross-sectional study for female patients who had a routine clinic visit were included. The Arizona Sexual Experience Scale (ASEX) was used to evaluate for FSD. Those with a total score of ≥ 19 or scored ≥ 5 on any item or ≥ 4 on three items were considered to have FSD.Results: A total of 253 female patients with a mean age of 39.1 ± 7.3 years were included. Two-thirds of the participants have no FSD. More than half (57.7%) of the participants had a strong desire for sex, and about 20% of the participants were unsatisfied with their orgasm. Compared to those with no FSD, those with FSD had lower BMI (P = 0.375), more likely to have a master’s degree or higher (P = 0.117), diabetes (P = 0.879), hypothyroidism (P = 0.625), diabetes-related microvascular and macrovascular complications (P = 0.049), higher HbA1c, fasting glucose, and TSH (P = 0.731, P = 0.161, and P = 0.561, respectively), lower total cholesterol and LDL (P = 0.368 and P = 0.339, respectively), and exercise more regularly (P = 0.929). Conclusion: One-third (32.5%) of the study participants had a FSD. Those with type 1 diabetes had the highest ASEX scores. We detected non-significant negative correlations between total ASEX score and both BMI and TSH, as well as a non-significant positive correlation between total ASEX score and both HbA1c and fasting glucose value.

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“…Also, our patients with positive urinary microalbuminuria were more likely to have FSD. Similar ndings were reported in previous studies in patients with chronic kidney disease (33,34) .…”

Section: Discussionsupporting

confidence: 92%

Prevalence of Sexual Dysfunction in Women with Type 1, 2 Diabetes and Thyroid Disorder: A Cross-Sectional Study in Taif City, Saudi Arabia

Alshehri¹,

Thobaiti

Alqurashi

et al. 2020

Preprint

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“…It is not surprising that item 3, vaginal lubrication, was the one which showed the greatest differences within the study sample: not only between diabetic women and controls, but also between women with complicated and uncomplicated DM. Other complications, such as nephropathy [37], retinopathy, foot ulcers [38,39] and autonomic heart disease [40,41], may also have a negative effect on the overall quality of life and, indirectly, on sexual activity.…”

Section: Discussionmentioning

confidence: 99%

Association between type 1 diabetes and female sexual dysfunction

Zamponi¹,

Mazzilli²,

Bitterman³

et al. 2020

BMC Women's Health

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Background: This study aims to evaluate: 1) the prevalence of Female Sexual Dysfunction (FSD) in women affected by type 1 Diabetes Mellitus (DM) and the control group; 2) the correlation between duration of DM, HbA1C levels and sexual life quality; 3) the relationship between different methods of insulin administration and sexual life quality; 4) the correlation between FSD and diabetes complications. Methods: We selected 33 women with type 1 DM and 39 healthy women as controls. Each participant underwent a detailed medical history and physical examination and completed the 6-item Female Sexual Function Index questionnaire (FSFI-6). In patients affected by type 1 DM, the different methods of insulin administration (Multi Drug Injection-MDI or Continuous Subcutaneous Insulin Infusion-CSII) and the presence of DM complications were also investigated. Results: The prevalence of FSD (total score ≤ 19) was significantly higher in the type 1 DM group than in the control group (12/33, 36.4% and 2/39, 5.2%, respectively; p = 0.010). No statistically significant differences were found regarding FSD according to the presence of complications, method of insulin administration or previous pregnancies. Conclusions: This study underlined that FSD is higher in women affected by type 1 DM than in healthy controls. This could be due to the diabetic neuropathy/angiopathy and the type of insulin administration. Therefore, it is important to investigate FSD in diabetic women, as well as erectile dysfunction in diabetic men.

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“…Finally, many hormonal abnormalities and sexual dysfunctions which occur in women with diabetes may be treated with progesterone alone or estrogen-progesterone combinations [ 36 , 37 ]. Although our report is an experimental study of DN in the rat, we provide a proof of concept evidence that progesterone may be effective in controlling both the sexual dysfunction and the DN in the diabetic women.…”

Section: Disscusionmentioning

confidence: 99%

Progesterone ameliorates diabetic nephropathy in streptozotocin-induced diabetic Rats

Al‐Trad

Ashankyty

Alaraj

2015

Diabetol Metab Syndr

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BackgroundPrevious studies reported that 17β-estradiol may influence the progression of diabetic renal disease in females. The present study was intended to provide an insight into the specific effects of progesterone, the other female sex hormone, in the diabetic renal complications.MethodsAdult female wistar rats were divided into four groups (n = 6/group): intact control (non-diabetic, ND), intact diabetic (D), ovariectomized diabetic (D-OVX) and ovariectomized diabetic which were treated with progesterone (D-OVX + P; 10 mg/kg, s.c, every second day) for 10 weeks. Diabetes was induced by a single dose injection of 55 mg/kg streptozotocin. Expressions of transforming growth factor-β (TGF-β), fibronectin, vascular endothelial growth factor-A (VEGF-A), angiotensin II type 1 receptor (ATR1) and podocyte markers (nephrin and podocin) were assessed by immunohistochemistry and real-time PCR.ResultsThe treatment of D-OVX rats with progesterone attenuated diabetic-associated increases in the urinary albumin to creatinine ratio, glomerulosclerosi and the expression of profibrotic and angiogenic factors (TGF-β, Fibronectin and VEGF-A). Furthermore, progesterone supplementation prevented diabetes-induced downregulation of nephrin and podocin while the overexpression of ATR1 in the diabetic rats was inhibited by the progesterone supplementation.ConclusionThese results provided evidence, for the first time, that the replacement of progesterone can ameliorate the renal damage in the experimental models of diabetic nephropathy through improving the renal function; the inhibition of renal fibrosis and abnormal angiogenesis; along with the amelioration of podocyte injury. Additionally, the blocking of renin-angiotensin system through the down-regulation of ATR1 expression may also account for the reno-protective effect of progesterone.Electronic supplementary materialThe online version of this article (doi:10.1186/s13098-015-0097-1) contains supplementary material, which is available to authorized users.

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Sexual Dysfunction in Women with Diabetic Kidney

Cited by 12 publications

References 29 publications

Prevalence of Sexual Dysfunction in Women with Type 1, 2 Diabetes and Thyroid Disorder: A Cross-Sectional Study in Taif City, Saudi Arabia

Prevalence of Sexual Dysfunction in Women with Type 1, 2 Diabetes and Thyroid Disorder: A Cross-Sectional Study in Taif City, Saudi Arabia

Association between type 1 diabetes and female sexual dysfunction

Progesterone ameliorates diabetic nephropathy in streptozotocin-induced diabetic Rats

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