Sexual dysfunction in men with type 2 diabetes

Abstract

Sexual dysfunction (SD) is common in type 2 diabetic men, but few subjects are diagnosed and treated. The prevalence of diabetes mellitus is increasing worldwide. It is expected that the number of subjects suffering from SD increases in the near future. Most studies of SD in diabetic men have focused on erectile dysfunction. There is a dearth of studies in the area of the other forms of SD. SD has consequences on the psychological well-being and reproductive function. They can be the first symptom of comorbidities or a treatment side effect. Erectile dysfunction is increasingly being recognised as an early marker of organic incipient systemic disease. Evaluation for any SD includes a complete medical history, detailed sexual history, physical examination, psychosocial assessment and, sometimes, complementary studies. Initial treatment of any SD should eliminate any modifiable factor that may lead to or aggravate the dysfunction. Phosphodiesterase type 5 inhibitors are the preferred therapy for most men with organic erectile dysfunction who do not have a specific contraindication to their use. Pharmacological treatment of premature ejaculation includes on-demand or daily dosing of certain selective serotonin reuptake inhibitors or clomipramine and on-demand topical local anaesthetics. Delayed ejaculation and anejaculation due to vascular or neuropathic damage are usually irreversible. The issue of infertility in patients with anejaculation or retrograde ejaculation seeking to have children should be addressed. No study specifically conducted in diabetic men on the treatment of hypoactive sexual desire disorder, apart from that occurring in the context of hypogonadism, has been published.

Sexual Dysfunctions as Self-Reported by Diabetic- Type-2 Men: An Andrology Clinic-Based Study in Alexandria, Egypt

“…DM is a medical problem which has its great implications on male sexual function [3,4]. The current study is a retrospective survey which evaluated the prevalence of different SDs as selfreported by a cohort of diabetic men who consulted directly an andrology public clinic.…”

“…Alexandria prefecture, with the prevalence of diabetes at 8%, has the second highest prevalence of diabetes among other Egyptian prefectures [1]. Diabetes is commonly associated with several sexual dysfunctions (SDs) [3,4]. Therefore, it is supposed that a significant number of Egyptian men with diabetes will suffer from different SDs.…”

Beneficial Effect of the Soluble Guanylyl Cyclase Stimulator BAY 41-2272 on Impaired Penile Erection in db/db−/− Type II Diabetic and Obese Mice

“…Although PDE-5 inhibitors are often the preferred therapy for most men with vasculogenic ED, the efficacy of these drugs is decreased in diabetic patients (Isidro, 2012), prompting a need for new treatment options. It has been shown that BAY 41-2272 is a potent relaxing agent in many tissues (Priviero et al, 2005;Teixeira et al, 2006a;Toque et al, 2008) including the CC.…”

Type 2 diabetes in men: facing the challenges

“…9 Phosphodiesterase type 5 inhibitors are the preferred therapy for most men with organic erectile dysfunction who do not have a specific contraindication to their use, in particular concurrent use (and not prescribing) of cardioactive nitrates. In addition, the vascular or neuropathic damage associated with long duration of type 2 diabetes often leads to delayed ejaculation and anejaculation, which is commonly irreversible.…”