Sexual dysfunction in Klinefelter's syndrome patients

Bardisi, Haitham El; Majzoub, Ahmad; Said, Sami Al; Alnawasra, H.; Dabbous, Zeinab; Arafa, Mohamed

doi:10.1111/and.12670

Cited by 18 publications

(23 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Yoshida found that 67.5% of subjects with KS have at least one sexual function disturbance [ 30 ]. In our study we found a prevalence of ED among patients with KS of 21.1%, which is comparable with previous literature regarding the prevalence of ED in KS [ 31 ].…”

Section: Discussionsupporting

confidence: 91%

“…This means that erectile function and desire are covariates negatively associated with E2/T and that low desire and ED may influence each other in patients with KS. In fact, these results are similar to those by El Bardisi et al, who found a significantly higher incidence of low libido in KS patients vs. controls (54.7% vs. 17.3%, respectively) despite normal testosterone levels [ 31 ].…”

Section: Discussionsupporting

confidence: 90%

See 1 more Smart Citation

Estradiol–Testosterone Imbalance Is Associated with Erectile Dysfunction in Patients with Klinefelter Syndrome

Ponce

Selice

Mambro

et al. 2021

JCM

View full text Add to dashboard Cite

Erectile dysfunction (ED) is a frequent sexual disorder in adult men. Klinefelter syndrome (KS) is the most common sex chromosomal disorder and a frequent cause of male hypogonadism. Psychological and cognitive aspects are quite typical in KS and have been linked to ED, while the role of testosterone (T) levels in sexual function of KS subjects has not been fully elucidated. The purpose of the present study is to investigate the role of hormonal disturbances in erectile function of subjects with KS. We conducted a retrospective study involving 52 Klinefelter patients newly diagnosed who never received androgen replacing therapy. All the subjects underwent medical history, accurate physical examination, and blood tests. The International Index of Erectile Function questionnaire (IIEF-EF) score correlated negatively with estradiol/testosterone ratio (E2/T); this correlation remained statistically significant after correction for age (ρ −0.320 p = 0.018). A multiple linear regression analysis identified age and E2/T as the main predictors of IIEF-EF score (R2 0.169 F = 3.848 p = 0.008). Our findings corroborate previous KS data obtained in the general population showing an association between higher E2/T ratio and impaired erectile function. Larger studies are required to better elucidate the pathophysiology of ED in patients with KS.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 90%

Estradiol–Testosterone Imbalance Is Associated with Erectile Dysfunction in Patients with Klinefelter Syndrome

Ponce

Selice

Mambro

et al. 2021

JCM

View full text Add to dashboard Cite

show abstract

“…Epidemiological studies of EjDs among infertile men are limited. Currently, three case-control studies 5 , 19 , 60 and six single-arm studies 17 , 22 , 40 , 61 , 62 , 63 have investigated PE among infertile men; one case-control 64 and one single-arm study 65 have looked at RE, while only one study have investigated the prevalence of anejaculation among infertile men 10 ( Table 3 ).…”

Section: Remarksmentioning

confidence: 99%

Male Sexual Dysfunctions in the Infertile Couple–Recommendations From the European Society of Sexual Medicine (ESSM)

et al. 2021

View full text Add to dashboard Cite

Introduction Sexual dysfunctions (SDs) have been frequently reported among male partners of infertile couples due to psychogenic, relational and/or organic issues related with the inability to conceive. Likewise, male infertility (MI) could be a consequence of sexual dysfunctions. Aim To review the evidence on the prevalence and treatment of male SDs in men of infertile couples and provide clinical recommendations on behalf of the European Society of Sexual Medicine (ESSM). Methods The MEDLINE database was searched in September 2019 for randomized clinical trials (RCTs), meta-analyses and open-label prospective or retrospective studies investigating the presence of erectile dysfunction (ED) and/or ejaculatory dysfunctions (EjDs) and/or low sexual desire (LSD) in conjunction with infertility. Main Outcome Measure The panel provided statements on: (i) Prevalence and association between SDs and MI; (ii) Treatment of male SDs in men of infertile couples. Results ED has been reported in 9% to 62% of male partners of infertile couples, with severe impairment observed in only 1% to 3% of ED cases. Moreover, worse semen parameters have been associated with greater ED severity. Phosphodiesterase type 5 inhibitors (PDE5is) can be safely used to treat ED among patients seeking fatherhood. Male partners of infertile couples are at higher risk of premature ejaculation (PE). Retrograde ejaculation (RE) and anejaculation are a cause of MI and can be managed with electroejaculation (EEJ) or penile vibratory stimulation (PVS) or, alternatively, with oral treatments, however the latter with limited documented success. Low sexual desire has been reported by one third of men of infertile couples. Conclusion ED could significantly affect male partners of infertile couple; PDE5is should be suggested to ensure an effective and satisfactory sexual relationship of the couple. Anejaculation and RE should be considered as a possible cause of MI and treated accordingly. Low sexual desire is frequently reported among men of infertile couple and could be a symptom of other systemic conditions or psychological distress. Capogrosso P, Jensen CFS, Rastrelli G, et al. Male Sexual Dysfunctions in the Infertile Couple–Recommendations From the European Society of Sexual Medicine (ESSM). J Sex Med 2021;9:100377.

show abstract

“…The strength of our study is related to the combined, medical (including biochemical, hormonal, and P‐CDU) and psychosexological, approach and to the evaluation of sexual function at baseline and after T replacement therapy. The percentage of ED among our KS cohort (14/62, 22.6%) is absolutely comparable to that found by Corona (5/23, 21.7%) (Corona et al ., ) and El Bardisi (10/53, 18.9%) (El Bardisi et al ., ). The prevalence of PE and DE was also similar between our study and that of Corona, but lower than that found by El Bardisi (22.6% of PE).…”

Section: Discussionmentioning

confidence: 97%

“…Yoshida found that 67.5% of KS subjects showed a disturbance in their sexual function, a prevalence however not different from a control group (Yoshida et al ., ). More recent studies showed that KS is associated with hypersexuality, paraphilic behaviors, and gender dysphoria, mediated by obsessive–compulsive and autistic traits (Fisher et al ., ), and with significant lower libido and incidence of premature ejaculation with respect to controls (El Bardisi et al ., ). The role of T levels and hypogonadism in sexual dysfunction of KS subjects has been poorly defined.…”

Section: Introductionmentioning

confidence: 97%

Endocrine and psychological aspects of sexual dysfunction in Klinefelter patients

et al. 2018

View full text Add to dashboard Cite

Klinefelter syndrome is a frequent cause of hypogonadism, but despite hundreds of publications on different aspects of Klinefelter syndrome, only a few studies dealt with sexual dysfunction. In particular, testosterone is critical for various aspects of sexual response, but its role on sexuality in Klinefelter syndrome patients is debatable and no studies have evaluated the efficacy of testosterone treatment on sexual dysfunction in these subjects. Furthermore, the impact of psychological and relational aspects on sexual function of Klinefelter syndrome subjects is poorly defined. In this study, we aimed to determine the presence and type of sexual dysfunctions in Klinefelter syndrome subjects; to correlate them with testosterone levels and psychosexological and relational domains; and to evaluate the effects of testosterone therapy. We studied 62 non-mosaic naïve Klinefelter syndrome patients and 60 age-matched controls by means of medical history, psychosexological history, 15-item International Index of Erectile Function questionnaire, endocrine assessment, and dynamic penile color Doppler ultrasound. Twenty-five hypogonadal Klinefelter syndrome patients were studied after 6 months of testosterone replacement therapy. Klinefelter syndrome subjects have reduced 15-item International Index of Erectile Function scores regarding sexual desire, intercourse satisfaction, and overall satisfaction with respect to controls, and these aspects were significantly associated with testosterone levels. Klinefelter syndrome subjects had also higher prevalence of erectile dysfunction, but no relation with testosterone levels was evident. A high prevalence of a range of psychological disturbances was present in Klinefelter syndrome subjects with erectile dysfunction with respect to those without erectile dysfunction. No statistical difference in the prevalence of premature and delayed ejaculation was observed between Klinefelter syndrome and control subjects. Testosterone replacement therapy improved sexual desire, intercourse satisfaction, and overall satisfaction scores, but had no effect on erectile function. Penile color Doppler ultrasound was normal in all subjects. This study shows that sexual dysfunction in Klinefelter syndrome is multifactorial and related only in part to hypogonadism and largely to psychological disturbances. Evaluation and therapy of sexual dysfunction should include a combined andrological and psychosexological approach.

show abstract

Sexual dysfunction in Klinefelter's syndrome patients

Cited by 18 publications

References 41 publications

Estradiol–Testosterone Imbalance Is Associated with Erectile Dysfunction in Patients with Klinefelter Syndrome

Estradiol–Testosterone Imbalance Is Associated with Erectile Dysfunction in Patients with Klinefelter Syndrome

Male Sexual Dysfunctions in the Infertile Couple–Recommendations From the European Society of Sexual Medicine (ESSM)

Endocrine and psychological aspects of sexual dysfunction in Klinefelter patients

Contact Info

Product

Resources

About