Sexual dysfunction associated with oral antihypertensive medication: A critical survey of the literature

Moss, Howard B.; Procci, Warren R.

doi:10.1016/0163-8343(82)90041-x

Cited by 60 publications

(34 citation statements)

References 42 publications

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“…26 One of the adverse effects that is known to affect adherence to antihypertensive therapy is sexual dysfunction, [27][28][29][30] and even the expectation that sexual function will be impaired may discourage a large number of patients from seeking appropriate antihypertensive therapy. 31 In the present study, stevioside was effective in lowering blood pressure and had a positive effect on QOL, as indicated by SF-36 scores and the absence of complaints about sexual function. Another important reason for poor compliance with antihypertensive regimens is the indefinite duration of therapy, [31][32][33] and one of the goals of antihypertensive therapy is to minimize the adverse impact of this factor on QOL.…”

Section: Discussionmentioning

confidence: 83%

“…31 In the present study, stevioside was effective in lowering blood pressure and had a positive effect on QOL, as indicated by SF-36 scores and the absence of complaints about sexual function. Another important reason for poor compliance with antihypertensive regimens is the indefinite duration of therapy, [31][32][33] and one of the goals of antihypertensive therapy is to minimize the adverse impact of this factor on QOL. 34 The need for multiple medications is an additional complicating factor 26 ; the compliance rate decreases as the number of daily medications increases.…”

Section: Discussionmentioning

confidence: 83%

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Efficacy and tolerability of oral stevioside in patients with mild essential hypertension: A two-year, randomized, placebo-controlled study

Hsieh¹,

Chan²,

Sue³

et al. 2003

Clinical Therapeutics

190

130

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Background: Stevioside, a natural glycoside isolated from the plant Stevia rebaudiana Bertoni, has been used as a commercial sweetening agent in Japan and Brazil for >20 years. Previous animal and human studies have indicated that stevioside has an antihypertensive effect.Objectives: This study was undertaken to investigate the long-term (2-year) efficacy and tolerability of stevioside in patients with mild essential hypertension. Secondary objectives were to determine the effects of stevioside on left ventricular mass index (LVMI) and quality of life (QOL).Methods: This was a multicenter, randomized, double-blind, placebocontrolled trial in Chinese men and women aged between 20 and 75 years with mild essential hypertension (systolic blood pressure [SBP] 140-159 mm Hg and diastolic blood pressure [DBP] 90-99 mm Hg). Patients took capsules containing 500 mg stevioside powder or placebo 3 times daily for 2 years. Blood pressure was measured at monthly clinic visits; patients were also encouraged to monitor blood pressure at home using an automated device. LVMI was determined by 2-dimensional echocardiography at baseline and after 1 and 2 years of treatment. QOL was assessed using the Medical Outcomes Study 36-Item Short-Form Health Survey. Electrocardiographic, laboratory, and QOL parameters were assessed at the beginning of treatment, and at 6 months, 1 year, and 2 years.Results: One hundred seventy-four patients (87 men, 87 women) were enrolled in the study, and 168 completed it: 82 (42 men, 40 women; mean [SD] age, 52 [7]

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 83%

Efficacy and tolerability of oral stevioside in patients with mild essential hypertension: A two-year, randomized, placebo-controlled study

Hsieh¹,

Chan²,

Sue³

et al. 2003

Clinical Therapeutics

190

130

View full text Add to dashboard Cite

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“…3 Treatment with antihypertensive agents may cause or exacerbate existing erectile dysfunction. 4,5 Some studies point towards ACE inhibitors, in particular, as playing as causative role. 6 However, other recent studies have suggested that the use of ACE inhibitors may be beneficial in improving ED.…”

Section: Introductionmentioning

confidence: 99%

Captopril treatment reverses erectile dysfunction in male Stroke Prone Spontaneously Hypertensive Rats

2002

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The involvement of antihypertensive therapy in the pathology of hypertension associated male erectile dysfunction is unclear. Stroke prone spontaneously hypertensive rats (SHRSP) were treated chronically with the angiotensin converting enzyme (ACE) inhibitor captopril or placebo, normotensive rats served as controls. Mean arterial and intracavernosal pressure were measured during the induction of erection by autonomic ganglion stimulation. SHRSP-placebo treated rats were hypertensive and had a blunted erectile response. Captopril treatment returned both the blood pressure and erectile response to control levels. Therefore, ACE inhibitor therapy may not be responsible for the erectile dysfunction observed in treated hypertensive subjects.

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“…Thiazide diuretics have been associated with ED, decreased libido, and failed ejaculation. 11,[16][17][18] However, the validity of these findings has been questioned. 19 One study concluded that ED and failed ejaculation were associated more with age than with diuretic use.…”

Section: Discussionmentioning

confidence: 99%

Antihypertensive treatment and erectile dysfunction in a cohort of type II diabetes patients

2003

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The association between different antihypertensive drugs and erectile dysfunction (ED) was examined in a cohort of type II diabetes patients identified in the UK General Practice Research Database (GPRD). The GPRD contains details of diagnoses, prescribing, investigations, risk factors, outcomes, and hospital referrals, together with basic demographic information for approximately six million patients from more than 450 representative general practices throughout the UK. A total of 634 cases and 2526 controls were included for analysis. Unconditional logistic regression analysis was performed to assess the risk of ED after adjusting for age at diabetes diagnosis date, cigarette smoking, depression, glycemic control, use of HMG-CoA reductase inhibitors, use of histamine receptor antagonists, use of digitalis medicines, and use of nitrates. Increased risk of ED was observed among patients taking the following antihypertensives: ACE inhibitors (OR ¼ 1.47, 95% CI ¼ 1.21, 1.80) and alpha blockers (OR ¼ 1.54, 95% CI ¼ 1.11, 2.12). However, we identified a nearly 30% reduction in risk among patients on diuretics (OR ¼ 0.73, 95% CI ¼ 0.54, 0.99). No statistically significant increase in risk was observed among users of beta blockers and calcium channel blockers (OR ¼ 1.05, 95% CI ¼ 0.85, 1.31) and (OR ¼ 1.14, 95% CI ¼ 0.91, 1.43), respectively. The results of this study confirm the strong and recognized effect of comorbidities in a diabetic population, but also require additional experimental and observational studies to further understand the potential benefit of diuretics and other ED treatments such as PDE5 inhibitors.

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Sexual dysfunction associated with oral antihypertensive medication: A critical survey of the literature

Cited by 60 publications

References 42 publications

Efficacy and tolerability of oral stevioside in patients with mild essential hypertension: A two-year, randomized, placebo-controlled study

Efficacy and tolerability of oral stevioside in patients with mild essential hypertension: A two-year, randomized, placebo-controlled study

Captopril treatment reverses erectile dysfunction in male Stroke Prone Spontaneously Hypertensive Rats

Antihypertensive treatment and erectile dysfunction in a cohort of type II diabetes patients

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